A5101455053- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Bone health and treatments
- Vasculitis and related conditions
- Monoclonal and Polyclonal Antibodies Research
- Vitamin D Research Studies
- Autoimmune and Inflammatory Disorders Research
- Finance, Taxation, and Governance
- CAR-T cell therapy research
- Bone health and osteoporosis research
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Cardiac Health and Mental Health
- Comparative International Legal Studies
- Reproductive Biology and Fertility
- Psoriasis: Treatment and Pathogenesis
- Ethics and bioethics in healthcare
- Immune Cell Function and Interaction
- Reproductive Health and Technologies
- Urinary Tract Infections Management
- T-cell and B-cell Immunology
Hospital Universitario La Paz
2013-2025
Institución Universitaria Escuela Nacional del Deporte
2025
Hospital Universitario Dexeus
2019-2023
Hospital Universitario de La Princesa
2022
BioCruces Health research Institute
2019
Center for Rheumatology
2013-2018
Instituto Nacional de Psiquiatría
2015
Sociedad Española de Reumatología
2013
Primary Health Care
2010
Anti-TNF drugs have proven to be effective against spondyloarthritis (SpA), although 30% of patients fail respond or experience adverse events leading treatment discontinuation. In rheumatoid arthritis, the presence anti-drug antibodies (ADA) first TNF inhibitor influences outcome after switching. Our aim was assess whether response a second anti-TNF drug is related previous development ADA SpA patients. Forty-two began failing therapy. Clinical activity assessed by Ankylosing Spondylitis...
Abstract OBJECTIVES Giant cell arteritis (GCA) is a large/medium-vessel granulomatous vasculitis, and the PD-1/PD-L1 coinhibitory pathway seems to be implicated in its pathogenesis. CD4 T cells expressing high PD-1 levels, CD4+CXCR5-PD-1hi peripheral helper (Tph) CD4+CXCR5+PD-1hi follicular (Tfh), are key mediators of autoimmunity. Their frequencies elevated blood subjects with several autoimmune conditions but have not been investigated GCA. Our objective was study frequency circulating Tph...
Soccer is the most popular sport worldwide, with an increasing number of professional players every year, and associated it, it complex unpredictable multiple physical, technical, tactical psychological problems critical to performance. In 90s, performance analysis based on tools included global positioning systems optical tracking for each player. For this reason, study aimed analyze physical technical variables related result a match fact that team qualifies different phases 2018 FIFA...
To estimate the prevalence of hepatitis C in a population northern Spain and describe (i) risk factors associated with infection (ii) distribution genotypes.Randomized cross-sectional study.A random sample 1,170 people participated study. Sociodemographic data were obtained. Antibodies against virus (anti-HCV) (HCV) genotypes determined.Nineteen (1.6%) subjects anti-HCV positive (95% CI 1.0-2.6%). In 12 cases (63%), viraemia was present, predominant genotype 1 b (80%). Anti-HCV older than...
Abstract Background Hypophosphatasia (HPP) is an inborn error of metabolism characterized by low levels serum alkaline phosphatase (ALP). Scarce evidence exists about features that should signal the potential association between hypophosphatasaemia and HPP in adults. The aim this study to estimate prevalence ALPL variants subjects with persistent determine associated clinical laboratory features. For cross-sectional study, records 386,353 were screened measurement ALP activity. A total 85...
Objective: The study aimed to determine the impact of age, age at menopause, body mass index (BMI), and lumbar hip bone mineral density (BMD) on muscle strength in young postmenopausal women with normal vitamin D levels.Methods: This was a cross-sectional performed 392 aged <65 years serum 25-hydroxyvitamin levels (≥30 ng/ml) no physical disabilities. following variables were recorded: BMI, BMD (measured by dual-energy X-ray absorptiometry [DXA] scanning expressed as T-scores), dominant hand...
Abstract Objective CD4+CXCR5+PD-1hi follicular helper T (Tfh) cells dwell in the germinal centres (GCs) of lymphoid organs and participate RA pathogenesis. The frequency their circulating counterparts (cTfh frequency) is expanded correlates with pool GC Tfh cells. Our objective was to study effect abatacept (ABT) or TNF blockers (TNFbs) on cTfh RA. Methods Peripheral blood drawn from seropositive, long-standing patients chronically receiving conventional synthetic DMARDs (csDMARDs; n = 45),...
This study was performed to determine the effectiveness of a cardiac rehabilitation and exercise training program on metabolic parameters coronary risk factors in patients with syndrome heart disease. The involved 642 Of them, 171 (26.7%) fulfilled criteria for syndrome. Clinical data, laboratory tests, testing were before after program, which lasted 2 3 months. Except waist circumference, there no significant differences between groups; blood pressure, high-density lipoprotein cholesterol,...
<h3>Background</h3> In psoriatic arthritis (PsA) with peripheral involvement classical DMARDs refractory, the anti-TNF therapy has proven to be effective. recent years, there are some publications that demostrate correlation between clinical activity and anti-drug antibodies (ADA) development in rheumatic diseases such as rheumatoid (RA) spondyloarthritis (SpA). To date, is no studies reveals theses findings PsA patients treated infliximab (Ifx) adalimumab (Ada). <h3>Objectives</h3> evaluate...
A subset of human circulating FoxP3+ regulatory T cells expresses CD39 (cTreg39+) and hydrolyses pro-inflammatory adenine nucleotides released at inflammatory foci, rendering the anti-inflammatory agent adenosine. Methotrexate (MTX), inhibiting ATIC, enhances extrusion may help Treg39+ control inflammation. Therefore, we examined relation cTreg39+ with effect MTX in early Rheumatoid Arthritis (eRA).
ABSTRACT BACKGROUND Giant cell arteritis (GCA) is a large/medium-vessel granulomatous vasculitis, and the PD-1/PD-L1 coinhibitory pathway seems to be implicated in its pathogenesis. CD4 T cells expressing high PD-1 levels, CD4+CXCR5-PD-1 hi peripheral helper (Tph) CD4+CXCR5+PD-1 follicular (Tfh), are key mediators of autoimmunity. Their frequencies elevated blood subjects with several autoimmune conditions but have not been investigated GCA. Our objective was study frequency circulating Tph...