A5101641528- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Spondyloarthritis Studies and Treatments
- Dermatology and Skin Diseases
- Cancer-related molecular mechanisms research
- Pharmaceutical studies and practices
- Adipose Tissue and Metabolism
- Management of metastatic bone disease
- Autoimmune and Inflammatory Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Nursing Diagnosis and Documentation
- Statistical Methods in Clinical Trials
- Phonocardiography and Auscultation Techniques
- Immune responses and vaccinations
- Endometrial and Cervical Cancer Treatments
- SARS-CoV-2 detection and testing
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Systemic Lupus Erythematosus Research
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Endometriosis Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- Gastric Cancer Management and Outcomes
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Shanghai Children's Medical Center
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Peking University
2023
Shanghai Jiao Tong University
2021
Janssen (United States)
2017-2019
Springhouse
2019
Computer-assisted auscultation has become available to assist clinicians with physical examinations detect congenital heart disease (CHD). However, its accuracy and effectiveness remain be evaluated. This study seeks evaluate the of auscultations abnormal sounds an artificial intelligence-assisted (AI-AA) platform we create.Initially, 1397 patients CHD were enrolled in study. The samples their recorded uploaded using a digital stethoscope. By platform, both remote by team experienced...
Lung cancer poses a serious threat to human health. Although targeted therapies have led breakthroughs in the treatment of lung cancer, drug resistance and side effects limit their clinical applications. Xihuang pill (XHW), classical anti-cancer traditional Chinese medicine formula, has been clinically proven be an effective complementary therapy various cancers. However, underlying mechanism for its use combination with drugs remains unclear. Here, we explored anti-lung effect XHW combined...
To explore the prognostic value of CT-based delta radiomics in predicting prognosis patients with stage IV gastric cancer treated immune checkpoint inhibitors (ICI).Forty-two cancer, who had received ICI monotherapy, were enrolled this retrospective study. Baseline and first follow-up CT scans analyzed. Intratumoral peritumoral regions interest (ROI) contoured, enabling extraction 192 features from each ROI. The intraclass correlation coefficients used to select high stability. least...
Abstract Background Evaluate the efficacy and safety of different chemotherapy regimens concurrent with radiotherapy in treating locally advanced cervical cancer (LACC). Methods Retrospective data was collected from LACC patients who were treated at our institution. These categorized into three groups: single-agent cisplatin (DDP) chemoradiotherapy group, paclitaxel plus (TP) nanoparticle albumin-bound (nab-) combined (nPP) group. The primary endpoints overall survival (OS) progression-free...
This study aimed to evaluate the effects of different vaccine regimens on mild and asymptomatic infections with SARS-CoV-2 Omicron BA.2 variant in Shanghai. All patients those symptoms were recruited from three major Fangcang shelter hospitals between March 26, 2022 May 20, 2022. Nucleic acid for by real-time reverse-transcription polymerase chain reaction methods nasopharyngeal swabs was assessed every day during hospitalization. The value cycle threshold lower than 35 considered as...
The infection rate of Coronavirus Disease 2019 (COVID-19) in children was less than that adults. However, the underlining reason is not well known.Children with COVID-19 were recruited from two Children's Hospitals Wuhan and Shanghai this case-control study. associations initial symptoms age, vaccinations Bacillus Calmette Guerin (BCG), influenza pathogens determined by Chi-square t-test.We evaluated 248 confirmed cases, 56 suspected cases COVID-19. median age 6.82 years old, 118 (38.82%)...
Abstract Aims Opioid addiction is a major public health issue, yet its underlying mechanism still unknown. The aim of this study was to explore the roles ubiquitin–proteasome system (UPS) and regulator G protein signaling 4 (RGS4) in morphine‐induced behavioral sensitization, well‐recognized animal model opioid addiction. Methods We explored characteristics RGS4 expression polyubiquitination development sensitization induced by single morphine exposure rats, effect selective proteasome...
Traditionally, clinical proof-of-concept (POC) trials were designed as mini-phase III with a lower power and/or an intermediate endpoint. And go/no-go decisions made based on specification of the Type I error. This article considers POC trial tool to select compound desired efficacy profile and introduces approach compute distribution treatment effect given go decision. The methodology is then applied three design options that range from direct comparison indirect comparisons utilizing...
Platinum-based chemotherapy, especially carboplatin, is the primary measure to treat patients with ovarian cancer (OC). However, OC still have an adverse prognosis due emergency of chemotherapy resistance. Ovarian serous cystadenocarcinoma (OSC) most common histological subtype OC. Therefore, identifying key factors that affect resistance and searching novel treatments had become a top priority. In this study, we analyzed carboplatin response-related mRNA, miRNA, DNA methylation, alternative...
To demonstrate the treatment effect on structural damage in rheumatoid arthritis (RA) and psoriatic (PsA), radiographic images of hands feet are scored according to Sharp scoring systems randomized clinical trials. However, quantification such an is challenging because overall mean progression lack interpretation. This article attempts shed a light statistical challenges resulted from its methods heterogeneity study population proposes mixture distribution model approach fit data. With...