A5100457695- Advanced Memory and Neural Computing
- Ferroelectric and Negative Capacitance Devices
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Calcium signaling and nucleotide metabolism
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Tree-ring climate responses
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Transition Metal Oxide Nanomaterials
- Semiconductor materials and devices
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Neuroscience and Neural Engineering
- Remote Sensing in Agriculture
- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Fire effects on ecosystems
- Plant Water Relations and Carbon Dynamics
National Heart Lung and Blood Institute
2016-2025
Dalian Medical University
2014-2025
Chongqing Medical University
2023-2025
Second Affiliated Hospital of Chongqing Medical University
2025
National Institutes of Health
2016-2024
North China University of Science and Technology
2024
Xinjiang Medical University
2023-2024
Shaanxi University of Technology
2024
Shanghai Cell Therapy Research Institute
2024
Revolution Medicines (United States)
2024
Resistance switching (RS) devices have potential to offer computing and memory function. A new computer unit is built of RS array, where processing storing information occur on same devices. states stored in located arbitrary positions array can be performed various nonvolatile logic operations. Logic functions reconfigured by altering trigger signals.
SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and cellulo to cyclize NAD produce Ca
Abstract Active mitochondrial DNA (mtDNA) elimination during spermatogenesis has emerged as a conserved mechanism ensuring the uniparental inheritance in animals. However, given existence of post-fertilization processes degrading sperm mitochondria, physiological significance mtDNA removal is not clear. Here we show that clearance indispensable for development and activity. We uncover previously unappreciated role Poldip2 exonuclease specifically expressed late required Drosophila . Loss...
Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status expression. PTEN plays multiple roles in tumor suppression, development, metabolism. Here, we report on the interplay of PTEN, histone H1, chromatin. We show that loss leads dissociation H1 from decondensation deletion also results elevation H4 acetylation at lysine 16, an epigenetic marker for activation. found physically interact through their C-terminal domains....
Three RNA helicases - DDX42, DDX46 and DHX15 are found to be associated with human U2 snRNP, but their roles mechanisms in snRNP spliceosome assembly insufficiently understood. Here we report the cryo-electron microscopy (cryo-EM) structures of DDX42-SF3b complex a putative precursor 17S that contains DDX42 (DDX42-U2 complex). is anchored on SF3B1 through N-terminal sequences, its N-plug occupying path SF3B1. The binding mode striking analogy DDX46. In DDX42-U2 complex, N-terminus remains...
EGFR is required for animal development, and dysregulation of critically implicated in malignant transformation. However, the molecular mechanism underlying regulation expression remains poorly explored. Here we report that zinc-finger protein ZNF516 a transcription repressor. physically associated with CtBP/LSD1/CoREST complex transcriptionally represses cohort genes including are involved cell proliferation motility. We demonstrate ZNF516-CtBP/LSD1/CoREST inhibits invasion breast cancer...
HfOx-based resistive switching device has been explored as one of the promising candidates for electronic synapses neuromorphic computing systems due to its high performance, low cost, and compatibility with CMOS technology. To meet codesign requirement neurons in systems, a compact model that can capture synaptic futures is developed. The developed accurately describe multilevel conductance transition behaviors during RESET process depression learning well binary stochastic behavior SET...
We aimed to retrospectively analyze the efficacy and safety of autologous bone marrow mesenchymal stem cells (BM-MSCs) as adjuvant therapy for intrauterine adhesion (IUA) endometrial repair. Patients enrolled at Shengjing Hospital Affiliated China Medical University from January 2017 2020 treatment infertility who diagnosed with recurrent IUA confirmed by hysteroscopy were included. BM-MSC was isolated patient's own collected before preserved. The patients admitted hospital hysteroscopic...
FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia (AML), and associated with poor prognosis a high relapse rate. Gilteritinib, second-generation FLT3 inhibitor, an important target drug for treating patients FLT3-internal tandem duplication (ITD) AML, approved treatment of relapsed/refractory FLT3-mutant leukemia, although challenges such as resistance reduced potency remain. Herein, mitoxantrone-liposomes sensitized FLT3-ITD AML cells to...
Faithful transmission or restoration of epigenetic information such as repressive histone modifications through generations is critical for the maintenance cell identity. We report here that chromodomain Y-like protein (CDYL), a chromodomain-containing transcription corepressor, physically associated with chromatin assembly factor 1 (CAF-1) and replicative helicase MCM complex. showed CDYL bridges CAF-1 MCM, facilitating transfer deposition during DNA replication. demonstrated recruits...
Abstract The traditional Boolean computing paradigm based on the von Neumann architecture is facing great challenges for future information technology applications such as big data, Internet of Things (IoT), and wearable devices, due to limited processing capability issues binary data storage computing, non-parallel processing, buses requirement between memory units logic units. brain-inspired neuromorphic believed be one promising solutions realizing more complex functions with a lower...
Background Colon cancer has always been diagnosed at a late stage, which is associated with poor prognosis. The currently used serum tumor markers CEA and CA19-9 display low sensitivity specificity may not have diagnostic value in early stage colon cancer. Thus, there an urgent need to identify novel biomarkers for use the detection of Methods In this study, expression DC-SIGN DC-SIGNR was detected by enzyme-linked immunosorbent assay (ELISA). tissues immunohistochemistry (IHC). Results...
Loss of function/dysregulation inhibitor growth 4 (ING4) and hyperactivation NF-κB are frequent events in many types human malignancies. However, the molecular mechanisms underlying these remarkable aberrations not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated JFK targets for ubiquitination degradation through assembly an Skp1–Cul1–F-box (SCF) complex. showed JFK-mediated destabilization leads to canonical pathway promotes angiogenesis metastasis...
Abstract BACKGROUND Bactrocera dorsalis (Hendel), a very destructive insect pest of many fruits and vegetables, is widespread in Asian countries. To facilitate control this pest, it essential to investigate its genetics gene function using targeted disruption. RESULTS Here, we describe successful mutagenesis the white transformer genes B. through use clustered regularly interspaced short palindromic repeats/CRISPR‐associated 9 (CRISPR/Cas9) system. Co‐injection sgRNA Cas9 mRNA into embryos...