A5100738031- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Photodynamic Therapy Research Studies
- Electronic Packaging and Soldering Technologies
- Antimicrobial Peptides and Activities
- Extracellular vesicles in disease
- Click Chemistry and Applications
- Photonic and Optical Devices
- Thyroid Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Thyroid and Parathyroid Surgery
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Electrocatalysts for Energy Conversion
- Porphyrin and Phthalocyanine Chemistry
- Atomic and Subatomic Physics Research
- Supramolecular Self-Assembly in Materials
- Advanced Fluorescence Microscopy Techniques
- MicroRNA in disease regulation
- Advanced Fiber Optic Sensors
- Lipid Membrane Structure and Behavior
Nanjing Medical University
2022-2025
The Ohio State University
2021-2025
Karolinska Institutet
2016-2025
Qujiang People's Hospital
2025
Guangdong Provincial People's Hospital
2025
Chinese University of Hong Kong
2020-2025
Jiangsu Province Hospital
2025
Guangzhou Medical University
2022-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
Tracking the dynamics of mitochondrial morphology has attracted much research interest because its involvement in early stage apoptosis and degenerative conditions. To follow this process, highly specific photostable fluorescent probes are demand. Commercially available mitochondria trackers, however, suffer from poor photostability. overcome limitation, we have designed synthesized a agent, tetraphenylethene-triphenylphosphonium (TPE-TPP), for imaging. Inherent mitochondrial-targeting...
Intracellular pH (pHi) is an important parameter associated with cellular behaviors and pathological conditions. Sensing pHi monitoring its changes in live cells are essential but challenging due to the lack of effective probes. We herein report a pH-sensitive fluorogen for sensing tracking. The dye tetraphenylethene-cyanine adduct (TPE-Cy). It biocompatible cell-permeable. Upon diffusing into cells, it responds sensitively entire physiological range, visualizing acidic basic compartments...
Amyloid fibrillation of proteins is associated with a great variety pathologic conditions. Development new molecules that can monitor amyloidosis kinetics and inhibit fibril formation diagnostic therapeutic value. In this work, we have developed biocompatible molecule functions as an ex situ in inhibitor for protein fibrillation, using insulin model protein. 1,2-Bis[4-(3-sulfonatopropoxyl)phenyl]-1,2-diphenylethene salt (BSPOTPE) nonemissive when it dissolved native incubation buffer but...
There is a great demand for long-term cellular tracers because of their importance in monitoring biological processes, pathological pathways, therapeutic effects, etc. Herein we report new type fluorescence "turn-on" probe tracing live cells over long period time. We synthesized the fluorogenic by attaching large number tetraphenylethene (TPE) labels to chitosan (CS) chain. The resultant TPE-CS bioconjugate shows unique aggregation-induced emission (AIE) behavior. It nonfluorescent when...
Molecules of siloles are almost non-fluorescent but their nanoaggregates highly emissive, exhibiting aggregation-induced emission (AIE). The AIE-active aggregates cytocompatible with living cells, stain cytoplasms HeLa cells indelibly without contaminating another type cell line in a co-culture system, and remain visible for long period time. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, not copy-edited or typeset. They...
Wearing face masks has been widely recommended to contain respiratory virus diseases, yet the improper use of poses a threat jeopardizing protection effect. We here identified bacteria viability on common and found that majority (90%) remain alive after 8 h. Using laser-induced graphene (LIG), inhibition rate improves ∼81%. Combined with photothermal effect, 99.998% bacterial killing efficiency could be attained within 10 min. For aerosolized bacteria, LIG also showed superior antibacterial...
A heteroatom-containing organic fluorophore 1-(4-pyridinyl)-1-phenyl-2-(9-carbazolyl)ethene (CP3E) was designed and synthesized. CP3E exhibits the effect of intramolecular charge transfer (ICT) caused by donor–acceptor interaction between its carbazole pyridine units. Whereas it emits faintly in solution, becomes a strong emitter aggregated state, demonstrating phenomenon aggregation-induced emission (AIE). Its can be reversibly switched blue dark states repeated protonation deprotonation....
This review outlines the fabrication methods and bioimaging applications of fluorescent nanoparticles based on AIE luminogens (AIE dots).
A series of tetraphenylethene-containing BODIPYs with emissions from visible to near-IR and large Stokes shifts up 142 nm have been designed synthesized. They show solvatochromic fluorescence can be utilized as fluorescent visualizers for intracellular imaging.
Resistance switching (RS) devices have potential to offer computing and memory function. A new computer unit is built of RS array, where processing storing information occur on same devices. states stored in located arbitrary positions array can be performed various nonvolatile logic operations. Logic functions reconfigured by altering trigger signals.
Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its...
We introduce a computational approach for the design of target-specific peptides. Our method integrates Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock peptide sequence generation and binding affinity assessment. Subsequently, molecular dynamics simulations are employed to narrow down selection peptides experimental assays. apply this strategy inhibitors that specifically target β-catenin NF-κB essential modulator. Among twelve inhibitors, six exhibit improved...
Melding a benzothiazolium unit with tetraphenylethene generates new hemicyanine luminogen aggregation-induced emission characteristics; the exhibits crystochromism and its solid-state can be repeatedly tuned from yellow or orange to red by grinding–fuming grinding–heating processes due transformation crystalline amorphous state vice versa.
Terpyridine-containing tetraphenylethenes (TPEs) are synthesized and their optical metal sensing properties investigated. They practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions poor solvents or thin films solid state, demonstrating a novel phenomenon of aggregation-induced emission (AIE). The nanoaggregates TPEs is pH-sensitive: it decreased eventually quenched upon protonation terpyridine units because AIE nature. can work "turn-off"...
In this work, a red-emissive zwitterionic hemicyanine dye, named TPE–Cy, containing tetraphenylethene (TPE) and N-alkylated indolium is designed synthesized. TPE–Cy inherits the aggregation-induced emission (AIE) feature of TPE displays large Stokes shift (>185 nm), overcoming limitations concentration-quenching effect small (from few to 20 nm) encountered by conventional cyanine dyes. By taking advantage photophysical AIE property chemical reactivity towards OH−/H+, able sense pH in broad...
Organic fluorescent probes are widely used in bioimaging and bioassays, but the notorious photobleaching hampers their applications. Encapsulation of organic dyes into nanoparticles (NPs) is an effective strategy to minimize photobleaching, classical dye molecules tend have fluorescence quenched aggregate states, which termed aggregation-caused quenching (ACQ). Here we demonstrate our attempt tackle this problem through aggregation-induced emission (AIE) strategy. 3,4:9,10-Tetracarboxylic...
Perylene bisimides (PBIs) are one class of the most explored organic fluorescent materials due to their high fluorescence quantum efficiency, electron transport behaviour, and ready form well-tailored supramolecular structures. However, they suffer from heavy aggregation-caused quenching (ACQ) effect which has greatly limited potential applications. We successfully tackle this problem by chemical modification PBI core with two tetraphenylethene (TPE) moieties at bay positions. This resulted...
In this work, a red emission AIE active mitochondrial probe is developed. It the first non-self-quenching mitochondria specific with membrane potential sensitivity. Its application in sensing differences mouse sperm cells demonstrated.
Significance Hydrogels maintain great potential for biomedical applications. However, predicting whether a chemical can form hydrogel simply based on its structure remains challenging. In this study, we developed combinational approach to obtain structurally diverse library with over 2,000 peptides as training dataset machine learning. We calculated their features, including topological and physicochemical properties, utilized learning methods predict the self-assembly behavior.
In this work, we report the synthesis and photophysical studies of a new luminogen, A3MN, diaminomaleonitrile-functionalized Schiff base. A3MN is aggregation-enhanced emission (AEE)-active: enhanced with aggregate formation. also possesses twisted intramolecular charge transfer (TICT) properties, showing noticeable solvatofluorochromism. Interestingly, crystals are nonemissive; defect areas crystal, however, highly emissive, as confirmed by spectroscopic methods confocal microscopy. By...
The rapid acquisition of antibiotic resistance poses difficulties in the development effective methods to eliminate pathogenic bacteria. New bactericides, especially those do not induce emergence resistance, are thus great demand. In this work, we report an aggregation-induced emission fluorogen, TPE-Bac, for bacterial imaging and elimination. TPE-Bac can be readily dissolved aqueous solution with weak emission. presence bacteria turn on its emission, no washing step is required process....
Abstract Near‐infrared (NIR) chemiluminescence (CL) emission is highly favorable for deep‐tissue imaging, but chemically conjugated NIR CL emitters with the aggregation‐induced (AIE) property biotechnology are seldom reported. Herein, an AIE‐active emitter, TBL, synthesized by conjugating luminol unit electron‐accepting benzothiadiazole and electron‐donating triphenylamine, subsequently TBL dots prepared using F127 as surfactant. The of can last continuously over 60 min be employed...