A5091380847- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Organoboron and organosilicon chemistry
- X-ray Diffraction in Crystallography
- Sulfur Compounds in Biology
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- Perovskite Materials and Applications
- Nicotinic Acetylcholine Receptors Study
- Cytomegalovirus and herpesvirus research
- Ocular Oncology and Treatments
- Photoreceptor and optogenetics research
- Nanocluster Synthesis and Applications
- Mercury impact and mitigation studies
Chinese PLA General Hospital
2025
University of Hong Kong
2021-2024
Hong Kong University of Science and Technology
2021-2024
National Research Center for Rehabilitation Technical Aids
2021
Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its...
Fluorescence-guided photodynamic therapy (PDT) has been considered as an emerging strategy for precise cancer treatment by making use of photosensitizers (PSs) with reactive oxygen species (ROS) generation. Some efficient PSs have reported in recent years, but multifunctional that are responsive to cancer-specific biomarkers rarely reported. In this study, we introduced a phosphate group biomarker alkaline phosphatase (ALP) on PS the features aggregation-induced emission (AIE) cell imaging...
Abstract Tumor‐targeted photodynamic therapy (PDT) is desirable as it can achieve efficient killing of tumor cells with no or less harm to normal cells. Herein, a facile molecular engineering strategy developed for photosensitizers (PSs) aggregation induced emission (AIE) characteristics and responsive properties the acidic microenvironment (TME). By marriage pH‐sensitive sulfonamide moieties AIE PSs, two near‐infrared luminogens called DBP‐SPy DBP‐SPh are designed synthesized. Both form...
Ultrahigh dose-rate (FLASH) radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity. However, tumor recurrence largely impede the effectiveness of FLASH therapy. Overcoming crucial for practical applications. Here, we prepared agarose-based thermosensitive hydrogel containing a mild photothermal agent (TPE-BBT) glutaminase inhibitor (CB-839). Within nanoparticles, TPE-BBT exhibits aggregation-induced emission peaked at 900 nm, while unrestricted...
Breast cancer (BC) remains a significant global health challenge for women despite advancements in early detection and treatment. Isoliquiritigenin (ISL), compound derived from traditional Chinese medicine, has shown potential as an anti-BC therapy, but its low bioavailability poor water solubility restrict effectiveness. In this study, we created theranostic nanoparticles consisting of ISL near-infrared (NIR) photosensitizer, TBPI, which displays aggregation-induced emission (AIE), with the...
Optogenetics has been plagued by invasive brain implants and thermal effects during photo-modulation. Here, two upconversion hybrid nanoparticles modified with photothermal agents, named PT-UCNP-B/G, which can modulate neuronal activities via photostimulation thermo-stimulation under near-infrared laser irradiation at 980 nm 808 nm, respectively, are demonstrated. PT-UCNP-B/G emits visible light (410-500 or 500-570 nm) through the process while they exhibit efficient effect no emission...
Molecular aggregates with environmental responsive properties are desired for their wide practical applications such as bioprobes. Here, a series of smart near-infrared (NIR) luminogens hyperlipidemia (HLP) diagnosis is reported. The these molecules exhibit twisted intramolecular charge-transfer effect in aqueous media, but aggregation-induced emission highly viscous media due to the restriction motion. These aggregates, which can autonomously respond different environments via switching...
A facile synthesized AIE bioprobe was developed to detect peroxynitrite sensitively and specifically. This can realize both <italic>in vitro</italic> ONOO<sup>−</sup> detection vivo</italic> visualization of inflammation.
Abstract Lung cancer, a highly prevalent and lethal form of is often associated with oxidative stress. Photodynamic therapy (PDT) has emerged as promising alternative therapeutic tool in cancer treatments, but its efficacy closely correlated to the photosensitizers generating reactive oxygen species (ROS) antioxidant capacity tumor cells. In particular, glutathione (GSH) can reduce ROS thus compromise PDT efficacy. this study, GSH‐responsive near‐infrared photosensitizer (TBPPN) based on...
Abstract Polymers containing lactam structures play a crucial role in both natural biological systems and human life, their synthesis, functions applications are of utmost importance for biomimetics the creation new materials. In this study, we developed an efficient heterogeneous Pauson–Khand polymerization (h‐PKP) method controlled synthesis main‐chain poly(γ‐lactam)s α, β‐unsaturated γ‐lactam functionalities using readily available internal alkynes imines. The molecular weights resulting...
Abstract Polymers containing lactam structures play a crucial role in both natural biological systems and human life, their synthesis, functions applications are of utmost importance for biomimetics the creation new materials. In this study, we developed an efficient heterogeneous Pauson–Khand polymerization (h‐PKP) method controlled synthesis main‐chain poly(γ‐lactam)s α, β‐unsaturated γ‐lactam functionalities using readily available internal alkynes imines. The molecular weights resulting...
Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) using small-molecule dyes is highly potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy has been successfully utilized to develop with donor-acceptor (D-A) structures acceptable QYs aggregate state, but there still a large room QY improvement. Here, we rationally designed emissive dye named TPE-BBT its...