A5058749160- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Magnesium in Health and Disease
- Genomics and Chromatin Dynamics
- Aluminum toxicity and tolerance in plants and animals
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Phytochemicals and Antioxidant Activities
- Ubiquitin and proteasome pathways
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Protein Hydrolysis and Bioactive Peptides
- Angiogenesis and VEGF in Cancer
- PARP inhibition in cancer therapy
- FOXO transcription factor regulation
- Microtubule and mitosis dynamics
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
- Sirtuins and Resveratrol in Medicine
- Metastasis and carcinoma case studies
- 14-3-3 protein interactions
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
Peking University
2013-2021
Xiamen University
2009-2010
Abstract Although SIRT7 is a member of sirtuin family proteins that are described as NAD + -dependent class III histone deacetylases, the intrinsic enzymatic activity this protein remains to be investigated and cellular function explored. Here we report an desuccinylase. We show recruited DNA double-strand breaks (DSBs) in PARP1-dependent manner catalyses desuccinylation H3K122 therein, thereby promoting chromatin condensation DSB repair. demonstrate depletion impairs compaction during...
p53 hydroxylation by JMJD6 represents a novel post-translational modification for p53. JMJD6-mediated regulates p53's transcriptional activity and the p53-dependent control of colon cancer.
Loss of function/dysregulation inhibitor growth 4 (ING4) and hyperactivation NF-κB are frequent events in many types human malignancies. However, the molecular mechanisms underlying these remarkable aberrations not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated JFK targets for ubiquitination degradation through assembly an Skp1–Cul1–F-box (SCF) complex. showed JFK-mediated destabilization leads to canonical pathway promotes angiogenesis metastasis...
ATP-binding cassette (ABC) transporters are implicated in a diverse range of physiological and pathophysiological processes, such as cholesterol lipid transportation multidrug resistance. Despite the considerable efforts made understanding cellular function ABC proteins, regulation mechanism this type protein is still poorly defined. Here we report identification functional characterization novel ATPase protein, associated with (PAAT), humans. PAAT contains nucleotide-binding domain...
Article11 June 2021free access Transparent process SCFJFK is functionally linked to obesity and metabolic syndrome Lin He orcid.org/0000-0001-7429-8012 Department of Biochemistry Molecular Biology, School Basic Medical Sciences, Key Laboratory Carcinogenesis Translational Research (Ministry Education), Peking University Health Science Center, Beijing, China Integration Chinese Western Medicine, ChinaThese authors contributed equally this work Search for more papers by author Ruorong Yan...
Selective thrombosis in tumor vessels is a novel vessel targeting strategy, which uses the molecules (peptide,antibody,and ligand) as carriers,and truncated tissue factor effector molecule. This paper reviews progress of its preclinical studies,treatment principles, treatment evaluation,difference three types therapy, influencing factors, and existing problems. Key words: Tumor; Blood vessel; Targeting therapy; Selective