A5100601490- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Genetic Associations and Epidemiology
- Cancer Mechanisms and Therapy
- Nanoplatforms for cancer theranostics
- Sirtuins and Resveratrol in Medicine
- Neurological Complications and Syndromes
- Cell Adhesion Molecules Research
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Mechanisms of cancer metastasis
- Plant and Fungal Species Descriptions
- Coronary Artery Anomalies
- Steroid Chemistry and Biochemistry
- Aortic Disease and Treatment Approaches
- Caveolin-1 and cellular processes
- Signaling Pathways in Disease
- Nanocluster Synthesis and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Capital Medical University
2004-2024
Fanjingshan National Nature Reserve
2024
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Jinan University
2024
Southwest Medical University
2023
Tianjin Medical University
2013-2019
Wuhan Center for Disease Control and Prevention
2019
Wuhan University
2018
Abstract Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related that has emerged as a prominent repressing in carcinogenesis. However, the role of RUNX2 breast cancer metastasis remains poorly understood. Here, we show recruits metastasis-associated 1 (MTA1)/NuRD and Cullin 4B (CUL4B)-Ring E3 ligase (CRL4B) complex to form transcriptional-repressive complex, which catalyzes histone deacetylation ubiquitylation. Genome-wide analysis RUNX2/NuRD(MTA1)/CRL4B targets identified...
As a commonly mutated form of the epidermal growth factor receptor, EGFRvIII strongly promotes glioblastoma (GBM) tumor invasion and progression, but mechanisms underlying this promotion are not fully understood. Through gene manipulation, we established EGFRvIII-, wild-type EGFR-, vector-expressing GBM cells. We used cDNA microarrays, bioinformatics analysis, target-blocking migration assays, Western blotting, an orthotopic U87MG model to examine phenotypic shifts treatment effects...
The RNA-binding protein Lin28 is known to promote malignancy by inhibiting the biogenesis of let-7, which functions as a tumor suppressor. However, role Lin28/let-7 axis in epithelial-to-mesenchymal transition (EMT) and stemness breast cancer has not been clearly expatiated. In our previous study, we demonstrated that let-7 regulates self-renewal tumorigenicity stem cells. present was highly expressed mesenchymal (M) type cells (MDA-MB-231 SK-3rd), but it barely detectable epithelial (E)...
Histone post–translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain multiple histone-binding domains. PHF1 [plant homeodomain (PHD) finger protein 1], which contains two kinds of histone reader modules, a Tudor domain PHD fingers, is an essential factor for epigenetic regulation genome maintenance. While significant progress has been made in characterizing the domain, roles fingers are poorly defined. Here,...
To find a natural plant essential oil (EO) with excellent antimicrobial effects on food-borne bacteria and to explore the mechanism of its function against Escherichia coli (E. coli).The activity seven EOs Gram-negative E. ATCC 8739 Gram-positive Staphylococcus aureus 6538 was investigated using agar disk diffusion method, minimum inhibitory concentration (MIC) bactericidal (MBC) each EO determined broth dilution method. The chemical composition Trachyspermum copticum (T. copticum) analyzed...
IL-17-producing Th17 cells have gradually become considered as key factors in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS). Although involvement certain microRNAs development MS has been reported, their role Th17-driven autoimmunity is still poorly understood. In this study, we identified microRNA (miR)-15b an important factor Th17-associated effects and determined that expression miR-15b significantly downregulated patients mice with experimental...
Lysine-specific demethylase 1 (LSD1) was the first histone identified as catalysing removal of mono- and di-methylation marks on H3-K4. Despite potential broad action LSD1 in transcription regulation, recent studies indicate that may coordinate with multiple epigenetic regulatory complexes including CoREST/HDAC complex, NuRD SIRT1, PRC2, implying complicated mechanistic actions this seemingly simple enzyme. Here, we report is also an integral component SIN3A/HDAC complex. Transcriptional...
The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations EZH2 and their role cancer pathogenesis. Here, we show that SET MYND domain containing (SMYD2) directly methylates at 307 (K307) enhances its stability, which can be relieved by H3K4 demethylase lysine-specific 1 (LSD1). SMYD2 critical for function repressing cohort genes governing...
Abstract The biological function of PRMT5 remains poorly understood in cervical cancer metastasis. Here, we report that physically associates with the transcription factor Snail and NuRD(MTA1) complex to form a transcriptional-repressive catalyzes symmetrical histone dimethylation deacetylation. This study shows Snail/PRMT5/NuRD(MTA1) targets genes, such as TET1 E-cadherin , which are critical for epithelial-mesenchymal transition (EMT). also affects conversion 5mC 5hmC. demonstrates...
Pancreatic cancer is a common malignant tumor with poor prognosis. Recently, stem cells (CSCs) were identified in several solid tumors, including pancreatic cancer. Although accumulating evidence indicates that sirtuin 1 (SIRT1) exerts biological functions various cancers, how it contributes to tumorigenesis and metastasis of cancer, as well its role CSCs, still poorly defined. Here we show SIRT1 interacts the Cullin 4B (CUL4B)-Ring E3 ligase (CRL4B) complex, which responsible for H2AK119...
Circadian rhythms, as physiological systems with self-regulatory functions in living organisms, are controlled by core clock genes and involved tumor development. The protein arginine methyltransferase 6 (PRMT6) serves an oncogene a myriad of solid tumors, including breast cancer. Hence, the primary aim current study is to investigate molecular mechanisms which PRMT6 complex promotes cancer progression. results show that PRMT6, poly(ADP-ribose) polymerase 1 (PARP1), cullin 4 B (CUL4B)-Ring...
Coactivator-associated arginine methyltransferase 1 (CARM1) promotes the development and metastasis of estrogen receptor alpha (ERα)-positive breast cancer. The function CARM1 in triple-negative cancer (TNBC) is still unclear requires further exploration. Here, we report that proliferation, epithelial-mesenchymal transition, stemness TNBC. upregulated multiple cancers its expression correlates with progression. Genome-wide analysis showed recruited by hypoxia-inducible factor-1 subunit...
Alterations in DNA methylation are demonstrated atherosclerosis pathogenesis. However, changing rules of global and hydroxymethylation peripheral blood leukocytes (PBLs) different cell subtypes coronary artery disease (CAD) patients still inconclusive, much less is known about mechanisms underlying. We recruited 265 CAD 270 healthy controls with genomic from PBLs, which 50 were randomly chosen isolated neutrophils, lymphocytes monocytes, RNA PBLs. Genomic 5-methylcytosine (5-mC)...
Bee pollen has been regarded as a complete nutritional human dietary supplement but its nutrient absorption and biological effects may be restricted by the complex wall. The aim of this study was to explore ultrasonic ball-milling treatment on release components in vitro vivo antioxidant rose (Rosa rugosa) bee pollen.Bee walls were broken varying degrees, nutrients released, improved. scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2'-azinobis(3-ethylbenzothiazolone-6-sulfonic acid) (ABTS)...
PHF20L1, a H3K27me2 reader, promotes breast tumorigenesis by cooperating with the PRC2/NuRD complex.
Abstract GATA3 has emerged as a prominent transcription factor required for maintaining mammary-gland homeostasis. loss is associated with aggressive breast cancer development, but the mechanism by which affected of function remains unclear. Here, we report that expression positively correlated UTX, histone H3K27 demethylase contained in MLL4 methyltransferase complex, and recruits chromatin-remodeling complex interacts directly ASH2L, RBBP5. Using RNA sequencing chromatin...
Cullin4B (CUL4B) is a scaffold protein of the CUL4B-Ring E3 ligase (CRL4B) complex. However, role CUL4B in development breast cancer remains poorly understood. Here it shown that CRL4B interacts with multiple histone deacetylase (HDAC)-containing corepressor complexes, including MTA1/NuRD, SIN3A, CoREST, and NcoR/SMRT complexes. It demonstrated CRL4B/NuRD(MTA1) complexes cooccupy E-cadherin AXIN2 promoters, could be recruited by transcription factors Snail ZEB2 to promote cell invasion...
Proteins containing the Jumonji C (JmjC) domain participated in tumorigenesis and cancer progression. However, mechanisms underlying this effect are still poorly understood. Our objective was to investigate role of AT-rich interaction domain-containing 2 (JARID2) - a JmjC family protein breast cancer, as well its latent association with obesity.Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, other databases were used analyze expression JARID2 cells. Growth curve,...
The homeodomain transcription factor SIX3 was recently reported to be a negative regulator of the Wnt pathway and has an emerging role in cancer. However, how contributes tumorigenesis metastasis is poorly understood.We employed affinity purification mass spectrometry (MS) identify proteins physically associated with SIX3. Genome-wide analysis SIX3/LSD1/NuRD(MTA3) complex using chromatin immunoprecipitation-on-chip approach identified cohort target genes including WNT1 FOXC2, which are...