A5054037070- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- ERP Systems Implementation and Impact
- Neuroscience and Neural Engineering
- Wound Healing and Treatments
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Ion channel regulation and function
- Information Technology Governance and Strategy
- Alzheimer's disease research and treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Innovation and Knowledge Management
- Neuroendocrine regulation and behavior
- Stroke Rehabilitation and Recovery
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Planarian Biology and Electrostimulation
- Electrospun Nanofibers in Biomedical Applications
- Glycosylation and Glycoproteins Research
- Collaboration in agile enterprises
- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- Facial Nerve Paralysis Treatment and Research
- Nanoplatforms for cancer theranostics
Nanjing Drum Tower Hospital
2015-2025
Nanjing Medical University
2017-2025
Research Institute of Radiology
2025
Washington University in St. Louis
2013-2024
Nanjing University of Chinese Medicine
2024
National Satellite Ocean Application Service
2019-2024
Model Animal Research Center
2024
Nanjing University
2024
University of South China
2013-2023
Ocean University of China
2023
Inflammatory responses are accountable for secondary injury induced by acute ischemic stroke (AIS). Previous studies indicated that O-GlcNAc modification (O-GlcNAcylation) is involved in the pathology of AIS, and increase O-GlcNAcylation glucosamine attenuated brain damage after ischemia/reperfusion. Inhibition β-N-acetylglucosaminidase (OGA) with thiamet G (TMG) an alternative option accumulating O-GlcNAcylated proteins. In this study, we investigate neuroprotective effect TMG a mouse model...
IL-17-producing Th17 cells have gradually become considered as key factors in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS). Although involvement certain microRNAs development MS has been reported, their role Th17-driven autoimmunity is still poorly understood. In this study, we identified microRNA (miR)-15b an important factor Th17-associated effects and determined that expression miR-15b significantly downregulated patients mice with experimental...
Epithelial-mesenchymal transition (EMT) allows neoplastic cells to gain the invasive phenotype and become migratory, which is required for cancer progression metastasis. In present study, expression of EMT-associated biomarkers their association with clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC) was investigated. E-cadherin, N-cadherin, β-catenin zinc finger E-box binding homeobox 2 (ZEB2) protein evaluated immunohistochemistry a cohort 76 patients operable LSCC....
Spontaneous activity is thought to regulate synaptogenesis in many parts of the developing nervous system. In vivo evidence for this regulation, however, scarce and comes almost exclusively from experiments which normal was reduced or blocked completely. Thus, whether spontaneous itself promotes plays a purely permissive role remains uncertain. addition, how influences synapse dynamics shape connectivity its effects among neurons are uniform cell-type-dependent unclear. mice lacking cone–rod...
Summary Aims Long noncoding RNA s (lnc s) play a key role in regulating immunological functions. Their impact on the chronic inflammatory disease multiple sclerosis ( MS ), however, remains unknown. We investigated expression of lnc peripheral blood mononuclear cells PBMC patients with and attempt to explain their possible process . Methods For this study, we recruited 26 according revised McDonald criteria. Then, randomly chose 6 for microarray analysis. Microarray assays identified...
Cochlear implants are currently the most effective treatment for profound sensorineural hearing loss. However, their therapeutic effect is limited by survival and proper physiological function of spiral ganglion neurons (SGNs), which targeted cochlear implant. It therefore critical to explore mechanism behind electric-acoustic stimulation (EAS) on SGNs. In this work, a biocompatible implant/graphene EAS system was created combining implant provide electrically transformed sound with graphene...
Abstract Spiral ganglion neuron (SGN) degeneration can lead to severe hearing loss, and the directional regeneration of SGNs has shown great potential for improving efficacy auditory therapy. Here, a novel 3D conductive microstructure with surface topologies is presented by integrating superaligned carbon‐nanotube sheets (SA‐CNTs) onto Morpho Menelaus butterfly wings SGN culture. The parallel groove‐like topological structures M. induce cultured cells grow along direction its ridges....
The risks associated with wound infections are significant, making a snug-fitting hydrogel dressing an optimal choice for management. For it, we employed the self-cross-linking method of oxidized sodium alginate (SCSA), incorporating clarithromycin (Cla) and basic fibroblast growth factor (bFGF) to formulate rapidly forming, bacteriostatic, wound-healing (SCSA@C/b). Bacteriostatic cytocompatibility assays demonstrated that SCSA@C/b exhibits exceptional antibacterial activity alongside strong...
Bacterial infection-induced acute sinusitisis prevalent and easy to convert into chronic sinusitis that is difficult heal with the increased environmental pollution bacterial drug resistance nowadays. For nasal cavity, flexibility hydrogels (LM@P/S@CP@Hemin) involve flexible wood-modified logs, photo-active conjugated polymers, immunomodulator (Hemin), immobilization hydrogel were prepared address this challenge. Hemin has a strong regulatory effect on macrophages perform anti-inflammation...
Hemostatic materials should have efficient and rapid hemostasis, good biocompatibility, nontoxicity. However, common hemostatic sponges often fail due to their weak mechanical strength, low slow hemostasis. Herein, we developed novel multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite by a freeze-drying method without adding any chemical cross-linking agents. The water absorption rate of the sponge is as high 4404%, blood 5460%. In vitro coagulation tests shown that...
Post-stroke depression (PSD) and post-stroke fatigue (PSF) are frequent persistent problems among stroke survivors. Therefore, awareness of signs symptoms PSD PSF is important for their treatment recovery from stroke. Additionally, since sudden serious illness can result in disequilibrium, early institution a coping process essential to restoring stability. The brain damage leaves patients with unique physical mental dysfunctions which maybe key resource while rebuilding lives. We evaluated...
Daily rhythms generated by endogenous circadian mechanisms and synchronized to the light-dark cycle have been implicated in timing of birth a wide variety species. Although chronodisruption (e.g., shift work or clock gene mutations) is associated with poor reproductive outcomes, little known about during pregnancy. This study tested whether daily change full-term pregnancies mice women. We compared running wheel activity continuously both nonpregnant ( n = 14) pregnant 13) 12- 24-week-old...
Photothermal therapy, because of its inherent high specificity and low invasiveness, can easily quickly inhibit infected wounds promote repair. Herein, flexible wood (LM) was synthesized combined with clarithromycin-carrying black phosphorus in a polyvinyl alcohol matrix to create highly effective photothermal wood-based hydrogel (LM@PBKb), which exhibited photodynamic bactericidal effects as well long-lasting wound sterility for the treatment skin wounds. The LM@PBKb conversion efficiency...
It is important to develop new antibiotics aimed at novel targets. The investigation found that the leaf extracts from five maples (Acer platanoides, Acer campestre, rubrum, saccharum and truncatum Bunge collected in Denmark, Canada China) their component tannic acid displayed antibacterial ability against 24 standard bacteria strains with minimum inhibitory concentration of 0.3-8.0 mg/mL. Unlike antibiotic levofloxacin (LFX), these samples inhibited Gram-positive more effectively than they...
Acute ischaemic stroke can induce secondary brain injury by activating an inflammatory response that contributes to clinical impairment. As a specific inhibitor of the immunoproteasome subunit low molecular weight polypeptide 7 (LMP7), PR-957 may participate in regulating pathophysiological and responses multiple diseases central nervous system (CNS). We investigated neuroprotective properties mouse model stroke, induced middle cerebral artery occlusion (MCAO). After MCAO injections or...