A5034321389- Veterinary Oncology Research
- Acute Kidney Injury Research
- Selenium in Biological Systems
- Chemotherapy-induced organ toxicity mitigation
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Chromosomal and Genetic Variations
- Infectious Diseases and Mycology
- Remote Sensing and Land Use
- Animal Virus Infections Studies
- Environmental Changes in China
- Escherichia coli research studies
- Trace Elements in Health
- Antibiotic Resistance in Bacteria
- Aquaculture disease management and microbiota
- Anesthesia and Sedative Agents
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Anesthesia and Neurotoxicity Research
- Microbial infections and disease research
- Molecular Biology Techniques and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Phytoestrogen effects and research
- Cancer-related Molecular Pathways
Nanjing Drum Tower Hospital
2024-2025
Northeast Agricultural University
2012-2024
Peking University
2012-2024
Shanghai Veterinary Research Institute
2023-2024
Chinese Academy of Agricultural Sciences
2010-2024
Southeast University
2007-2024
Nanchang University
2024
Education Department of Heilongjiang Province
2023-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2008-2024
Shandong Provincial Hospital
2024
Biofilm infections can induce chronic inflammation and stall the normal orchestrated course of wound-healing cascades. Herein, pH-switchable antimicrobial hydrogel with nanofiber networks for biofilm eradication rescuing stalled healing in wounds is reported on basis self-assembly a designed octapeptide (IKFQFHFD) at neutral pH. This biocompatible exhibits an acidic pH (pathological environment infected wounds)-switchable broad-spectrum effect via mechanism involving cell wall membrane...
This study provides genetic evidences at the chromosome, DNA content, fragment and sequence, morphological levels to support successful establishment of polyploid hybrids red crucian carp x blunt snout bream, which belonged a different subfamily fish (Cyprininae Cultrinae subfamily) in catalog. We successfully obtained sterile triploid bisexual fertile tetraploid (RCC) (female symbol) bream (BSB) (male as well their pentaploid hybrids. The possessed 124 chromosomes with two sets from RCC one...
Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality worldwide, there currently no effective means to prevent it. Dioscin naturally present in the dioscoreaceae plants has antioxidant anti-inflammatory effects. Here, we found that dioscin protective against cisplatin-induced AKI. Pathological ultrastructural observations revealed reduced renal tissue lesions mitochondrial damage. Furthermore, markedly suppressed reactive oxygen species malondialdehyde levels...
In this article, sequence analysis of the coding region (5S) and adjacent nontranscribed spacer (NTS) were conducted in red crucian carp (RCC), blunt snout bream (BSB), their polyploid offspring. Three monomeric 5S rDNA classes (designated class I: 203 bp; II: 340 III: 477 bp) RCC characterized by distinct NTS types NTS-I, II, III for 83, 220, 357 bp monomers, respectively). BSB, only one was observed IV: 188 bp), which type NTS-IV: 68 bp). offspring, tetraploid (4nRB) hybrids partially...
Cochlear implants are currently the most effective treatment for profound sensorineural hearing loss. However, their therapeutic effect is limited by survival and proper physiological function of spiral ganglion neurons (SGNs), which targeted cochlear implant. It therefore critical to explore mechanism behind electric-acoustic stimulation (EAS) on SGNs. In this work, a biocompatible implant/graphene EAS system was created combining implant provide electrically transformed sound with graphene...
Effective and targeted prevention treatment methods for acute kidney injury (AKI), a common clinical complication, still needs to be explored. Paricalcitol is biologically active chemical that binds vitamin D receptors in the body exert anti-oxidant anti-inflammatory effects. However, molecular mechanism of effect paricalcitol on AKI remains unclear. The current study uses pretreatment with mouse model induced by cisplatin detect changes renal function, pathology ultrastructure. Results...
ABSTRACT Aim: Despite significant advances in medical management and therapeutics, acute kidney injury (AKI) is still a common serious complication with high morbidity mortality hospitalized patients, especially patients admitted to the intensive care unit (ICU). The primary purpose of this study apply definition proposed by Acute Kidney Injury Network (AKIN) investigate incidence, 28‐day risk factors for prognosis AKI ICU. Methods: In retrospective study, data from cohort 4642 five ICUs...
The fertility of fish is a key factor in breeding. RNA-seq widely used high-throughput sequencing and provides rapid method to examine the molecular mechanisms underlying biological process. To probe fertility-related mechanisms, we obtained testis transcriptomes from diploid triploid cyprinid tested for differentially expressed genes (DEGs) testis. A total 6730 transcripts were between fish. In these transcripts, 2428 showed reduced expression 4302 overexpressed compared Functional analyses...
Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have described epidemiology diagnosis of AKI China. The aim this study was to describe incidence hospitalized adult patients tertiary teaching hospital southeast All from October 1, 2013 September 30, 2014 First Affiliated Hospital Nanjing Medical University were screened using Lab Administration Network. definition staging based KDIGO...
Abstract Since its first identification in prostate cancers and tissues, transient receptor potential melastatin-subfamily member 8 (TRPM8) is subsequently found to be overexpressed a wide range of shown implicated tumorigenesis tumor progression. Here, we used N-(3-aminopropyl)-2-[(3-methylphenyl) methoxy] -N-(2-thienylmethyl) benzamide hydrochloride (AMTB), specific TRPM8 antagonist, explore antitumoral effect on osteosarcoma. We find that AMTB suppresses osteosarcoma cell proliferation,...
Enterotoxigenic Escherichia coli (ETEC) can damage intestinal epithelial barrier function and lead to serious diarrhea in newborns young animals. Sodium humate (HNa) is natural organic bioactive compound possessing antibacterial, anti-inflammatory, anti-diarrheal properties. This study investigated the alleviative potential of HNa on impaired inflammation, regulatory effects gut microbiota metabolites ETEC K88 infected mice. A total 30 female mice were randomly assigned into three groups....
The use of vitamin D 3 represents a novel and pragmatic strategy to alleviate CP-induced intestinal injury via its antioxidant anti-ferroptosis activity. Ferroptosis may be promising target for the attenuation injury.
Selenium (Se) is essential for human and animal health, but there have been few studies on the mechanisms of injury in dairy cows with Se deficiency. This study aimed to evaluate effects deficiency myocardial weaned calves. The Se-D group had significantly lower concentrations than Se-C group. Histological analysis indicated that induced a large area necrosis myocardium, accompanied by inflammatory changes. decreased expression 10 21 selenoprotein genes increased SEPHS2. Furthermore, we...
Feline coronavirus (FCoV) is an unsegmented, single-stranded RNA virus belonging to the Alphacoronavirus genus. It can cause fatal feline infectious peritonitis (FIP) in cats of any ages. Currently, there are no effective prevention and control measures against FCoV. In this study, we developed a recombinant adenovirus vaccine, AD5-N, based on nucleocapsid(N) protein The immunogenicity AD5-N was evaluated through intramuscular immunization 6-week-old Balb/c mice 9–12 months old cats....
The objective of this study was to investigate the protective effects and mechanisms dietary administration sodium humate (HNa) its zinc selenium chelate (Zn/Se-HNa) in mitigating Salmonella Typhimurium (S. Typhi) induced intestinal injury broiler chickens. Following gavage 109 CFU S. Typhi 240 broilers from 21-day 23-day aged, various growth performance parameters such as body weight (BW), average daily gain (ADG), feed intake (ADFI), ratio (FCR) were measured before after infection....
Background Porcine deltacoronavirus (PDCoV), a novel swine enteropathogenic coronavirus, challenges the global industry. Currently, there are no approaches preventing from PDCoV infection. Methods A new strain named JS2211 was isolated. Next, dimer receptor binding domain of spike protein (RBD-dimer) expressed using prokaryotic expression system, and nanoparticle containing RBD-dimer ferritin (SC-Fe) constructed SpyTag/SpyCatcher system. Finally, immunoprotection RBD-Fe nanoparticles...