A5100616227- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Aquaculture Nutrition and Growth
- Ferroptosis and cancer prognosis
- Aquaculture disease management and microbiota
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Signaling Pathways in Disease
- Pluripotent Stem Cells Research
- Amino Acid Enzymes and Metabolism
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Chromosomal and Genetic Variations
- Connexins and lens biology
- Endoplasmic Reticulum Stress and Disease
- Genomics and Chromatin Dynamics
- Listeria monocytogenes in Food Safety
- Fish Biology and Ecology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Nuclear and radioactivity studies
- Receptor Mechanisms and Signaling
- Dental Trauma and Treatments
- RNA regulation and disease
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Hebei Normal University of Science and Technology
2023
Wuhan National Laboratory for Optoelectronics
2023
Huazhong University of Science and Technology
2023
Hunan Normal University
2004-2022
Anhui Agricultural University
2022
South China Agricultural University
2022
Third Xiangya Hospital
2020
Central South University
2020
Aberrant activity of polycomb repressive complex 2 (PRC2) is involved in a wide range human cancer progression. The WD40 repeat-containing protein EED core component PRC2 and enhances through interaction with H3K27me3. In this study, we report the discovery class pyrimidone compounds, represented by BR-001, as potent allosteric inhibitors PRC2. X-ray co-crystallography showed that BR-001 directly binds H3K27me3-binding pocket. displayed antitumor potency vitro vivo. Karpas422 Pfeiffer...
Abstract Background Heterosis of growth traits in allotriploid fish has benefited the production aquaculture for many years, yet its genetic and molecular basis remained obscure. Now, an complex, including two triploids their diploid inbred parents, provided excellent model investigating potential regulatory mechanisms heterosis. Results Here, we performed a series analyses on DNA methylation modification miRNA expression combination with gene complex. We first established cis - trans...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic and healthcare systems worldwide. However, the currently available therapy of AD limited, new strategies are needed to enhance clearance β-amyloid (Aβ) protein improve cognitive function. Photobiomodulation (PBM) non-invasive effective therapeutic method has shown promise in treating various brain diseases. Here, we demonstrate 1267-nm PBM significantly alleviates decline...
The technique of induced pluripotent stem cells has significant application value in breeding and preserving the genetic integrity fish species. However, it is still unclear whether chemically can be from non-mammalian or not. In this article, we first verify that fibroblasts reprogrammed into cells. These stem-like possess features colony morphology, expression marker genes, formation embryoid bodies, teratoma formation, potential to differentiate germ cell-like vitro. Our findings will...
The present study was conducted to investigate the volatile compounds profile of raw muscle between diploid (2n = 100) and triploid crucian carp (produced by hybridization from mating allotetraploid, 3n 150) cultured under same conditions. Volatile ploidy were qualitatively analyzed headspace solid-phase microextraction gas chromatography-tandem mass spectrometry (HS-SPME-GC/MS). A total 52 volatiles identified in two groups including 5 alcohols, aromatics, 8 aldehydes, 1 ketone, 10 alkanes,...
Rationale: Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case coexistence MN, provide the exact relationship these 2 entities recognized some causes renal involvement AS. Patient concerns: A 44-year-old female presented pain left leg for 4 years pedal edema weeks. Diagnoses: was diagnosed...
SHC3 is exclusively expressed in postmitotic neurons, while SHC1 found neural stem cells and precursor but absent mature neurons. In this study, we discovered that suppression of p52SHC1 expression by RNA interference resulted proliferation defects cells, along with significantly reduced protein levels cyclin E A. At the same time, p52SHC3 RNAi caused cell cycle re-entry (9.54% S phase 5.70% G2-M phase) primary neurons up-regulated D1, E, A, CDK2, phosphorylated CDK2. When was overexpressed,...
Damaged cottonseeds has a disadvantageous influence on cotton yields. The traditional detection of depends just labor, which is tedious and variant with different operator. An automatic system based machine vision was designed to distinguish the sound from damaged ones. objective this study develop image processing algorithms finish picking out cottonseeds. During development algorithm, three statistical characteristics, mean, variance ratio mean (RMV), were used. Different sizes window...
Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all cancers, and its early late recurrences still threaten patients' long-term survival quality life. Finding candidate tumor antigens potential therapeutic targets is critical to addressing these unmet needs.
Spinal cord injury and regeneration involves transcriptional activity of many genes, which remain unknown. Using the rat spinal full- transection model, bioinformatics, cloning, expression assays, fusion proteins, transfection techniques, we identified characterized one such differentially expressed gene, termed scirr1 (spinal and/or related gene 1). Fourteen orthologs were found in 13 species from echinoderm to insect human by Blast search NCBI protein reference sequence database. However,...
The Recurrent depression leads to disability and high health care costs. Identification of biomarkers for diagnosis recurrent will be helpful predict prevent the recurrence depression. Sprague-Dawley rats were exposed re-exposed chronic unpredicted mild stress mimic onset Rat’s serum was collected analyzed by gas chromatography/time-of-flight mass spectrometry. Palmitinic acid oleinic found decreased in alanine, 6-Desoxy-Mannopyranose, acid, stearic cholesterol These data shows suffer have...