A5101547035- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Blood donation and transfusion practices
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Laser Applications in Dentistry and Medicine
- Plant and Fungal Interactions Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Animal Genetics and Reproduction
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Reproductive biology and impacts on aquatic species
- Wnt/β-catenin signaling in development and cancer
- Genetic and Environmental Crop Studies
- Ferroptosis and cancer prognosis
- Magnesium Alloys: Properties and Applications
- T-cell and B-cell Immunology
- Genetic Associations and Epidemiology
- Cardiovascular and exercise physiology
- Seed and Plant Biochemistry
- Dental Anxiety and Anesthesia Techniques
- FOXO transcription factor regulation
- Optical Imaging and Spectroscopy Techniques
- Metal and Thin Film Mechanics
- Probiotics and Fermented Foods
Zhongda Hospital Southeast University
2024-2025
Wuhan National Laboratory for Optoelectronics
2022-2024
Huazhong University of Science and Technology
2022-2024
Nanjing University
2021-2024
University of Electronic Science and Technology of China
2023
Lanzhou University
2023
Yancheng Central Blood Station
2023
Shanghai Jiao Tong University
2019-2023
Sichuan University
2023
Fujian Medical University
2023
Abstract Background Ovarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have emphasized significant role cancer-associated fibroblasts (CAFs) in OC development progression. Methods Employing sophisticated machine learning techniques on bulk transcriptomic datasets, we identified fibroblast growth factor 7 (FGF7), derived from CAFs, as a potential oncogenic factor. We investigated relationship between FGF7...
Hypertension is a major health risk that influences the quality of life for many people. The importance monitoring hypertension in continuous and noninvasive manner increases as more people experience raised blood pressure (BP). authors present smartphone-centric body sensor network to measure pulse transit time (PTT) real time. Their robust method calculating BP uses PPT information considers baroreflex mechanism, which reflects relationship between heart rate. To evaluate performance their...
The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood–brain barrier, limiting drug delivery to central nervous system (CNS). Transcranial photobiomodulation (tPBM) a promising technology treating diseases, due its effectiveness, non-invasiveness, and affordability. tPBM has been widely used in pre-clinical experiments clinical trials such as stroke Alzheimer's disease. This review provides comprehensive overview tPBM. We summarize...
Due to the unique geographical and climatic conditions in Nagqu (Tibet), blood station laboratory was only fully established accredited by 2020. This study validated performance of laboratory's screening system analyzed recent trends donation effectiveness. Various serum samples were used assess hepatitis B, C, HIV, syphilis tests, both serological nucleic acid tests. Donation data also collected analyzed. Serological testing demonstrated excellent sensitivity, specificity, reproducibility...
The existing drugs for ovarian cancer (OC) are unsatisfactory and thus new drug targets urgently required. We conducted proteome-wide Mendelian randomization (MR) colocalization analysis to pinpoint potential OC. Data on protein quantitative trait loci (pQTL) 734 plasma proteins were obtained from large genome-proteome-wide association studies. Genetic associations with OC derived the Ovarian Cancer Association Consortium, which included 25,509 cases 40,941 controls. MR was performed...
High expression of secreted matricellular protein cysteine-rich 61 (CYR61) correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer activation has been shown to correlate key genes involved progression. However, such mechanisms CYR61 transcription regulation remain unexplored.Expression was determined by immunohistochemistry (IHC), quantitative real-time PCR (qRT-PCR) and western blotting (WB) CRC patients paraffin specimens colon cell lines. ChIP-seq data...
Genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated 9 (Cas9)-mediated loss-of-function screens are powerful tools for identifying genes responsible diverse phenotypes. Here, we perturbed in melanoma cells to screen involved tumor escape from T cell-mediated killing. Multiple interferon gamma (IFNγ) signaling-related were enriched resistant cell In addition, deletion of the deubiquitinating protease ubiquitin specific peptidase 22 (USP22) mouse...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic and healthcare systems worldwide. However, the currently available therapy of AD limited, new strategies are needed to enhance clearance β-amyloid (Aβ) protein improve cognitive function. Photobiomodulation (PBM) non-invasive effective therapeutic method has shown promise in treating various brain diseases. Here, we demonstrate 1267-nm PBM significantly alleviates decline...
Somatic gene mutations play a critical role in immune evasion by tumors. However, there is limited information on genes that confer immunotherapy resistance melanoma. To answer this question, we established whole-genome knockout B16/ovalbumin cell line clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease technology, and determined vivo adoptive OT-I T-cell transfer an vitro T-cell-killing assay Janus kinase (JAK)1 deficiency mediates via...
Continuous spermatogenesis from puberty to old age in males relies on spermatogonial stem cells (SSCs) that possess the property of self-renewal and differentiation. The delicate balance between differentiation is great importance. In mice, SSCs exist as a subpopulation undifferentiated spermatogonia. are controlled by intrinsic molecular pathways can be activated extrinsic signals. Our results here first show expression forkhead box C2 (FOXC2) restricted GFRα1-positive spermatogonia testis....
Glutathione S-transferase P1 (GSTP1) has gradually become a promising target for cancer prevention and treatment. However, subtle variations in GSTP1 can lead to the occurrence of single nucleotide polymorphisms (SNPs). The correlation between specific genotypes clinical outcome disease been extensively investigated, demonstrating significant area research this field. their impact on responses inhibitor treatment remains be elucidated. Among various SNPs GSTP1, I105V is most widely studied....
The workflow of virtual screening for the discovery GSTP1 inhibitors.
Systemic inflammation and severe fibrosis can reduce serum zinc levels, while supplementation is reported to improve the prognosis of patients with chronic liver disease (CLD). We aimed investigate clinical application in CLD anti-infective mechanism supplementation. Based on level, 149 were divided into 3 groups their parameters compared. In in-vitro experiments, microbial isolates derived from used stimulate human non-parenchymal cells, sulfate solution was added certain experiments. The...
Abstract The aim of this study was to evaluate the performance blood screening strategies in Nagqu City, with a focus on serological and nucleic acid testing effectiveness. Analysis donation data from 2017 2023 revealed gradual increase local rates, but rate unqualified donations remained higher than national average. Serological verification showed good repeatability precision, improvements are needed accuracy certain markers. Nucleic demonstrated excellent detection capability for low...