A5103944682- CAR-T cell therapy research
- Multilevel Inverters and Converters
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Acne and Rosacea Treatments and Effects
- Pharmacological Effects of Natural Compounds
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Hip disorders and treatments
- Microgrid Control and Optimization
- Advanced DC-DC Converters
- Bee Products Chemical Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- Tendon Structure and Treatment
- Advanced optical system design
- Advanced Radiotherapy Techniques
- Radar Systems and Signal Processing
- Bone and Joint Diseases
- Long-Term Effects of COVID-19
- Distributed Control Multi-Agent Systems
- Phagocytosis and Immune Regulation
- Integrated Circuits and Semiconductor Failure Analysis
Nanyang Technological University
2024-2025
Nanjing University of Aeronautics and Astronautics
2024
Nanchang University
2024
Shanghai Jiao Tong University
2018-2023
Xiamen University
2023
Northeast Forestry University
2023
Southern University of Science and Technology
2022
University of Michigan–Ann Arbor
2022
Beijing Institute of Technology
2021
University of Electronic Science and Technology of China
2021
Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). Here we show that isotype and intrinsic agonistic strength co-determine the anti-4-1BB mAb-AG. While intrinsically strong can activate absence FcγRs, weak antibodies rely on FcγRs to 4-1BB. All crosslink anti-41BB strengthen...
Purpose: To evaluate the potential added value of integrating anti-apoptotic molecules for improving anti-tumor activity CAR-T cells. Methods: Four small inhibiting apoptosis were tested their ability to prevent activated induced cell death. Five CD20-targeting, CD137 (4-1BB) and CD3ζ integrated cells (20BBZ) with constitutively expressed genes established, we screened out strongest proliferation enhancer: Bcl-2. The memory subtype exhaustion markers analyzed. activities Bcl-2 (20BBZ-Bcl-2)...
As one of the most important technologies for next generation very-large scale integrated circuit fabrication, extreme ultraviolet (EUV) lithography has attracted more and attention in recent years.However, EUV lithography, optical distortion printed image on wafer always negative impacts imaging performance.Thus, to enhance performance system, especially small critical dimensions, this work, a novel proximity correction (OPC) system based deep learning technique is proposed.It includes...
Abstract Time-restricted feeding (TRF) is a dietary strategy used to prevent and treat obesity in both sexes. However, TRF affects liver metabolism differently males females, the mechanisms behind these differences remain unclear. Our study reveals that during TRF, female livers are more likely break down amino acids (AAs) synthesize fats, while male significantly reduce fatty acid synthesis. The changes liver’s AA metabolic profile after gonadectomy suggest estrogen signaling crucial for...
Related studies have pointed out that cell adhesion may play an important role for treating Polycystic Ovary Syndrome (PCOS). This study aimed to identify and analyze the biomarkers associated with adhesion-related genes (CRGs) PCOS their biological mechanisms. In this study, GSE80432 was used differentially expressed (DEGs) (PCOS vs control group) through differential expression analysis. Then, DEGs were overlapped 1531 CRGs obtain cross - genes. Subsequently, Support Vector...
Abstract The success of chimeric antigen receptor (CAR) T cells in treating B cell malignancies comes at the price eradicating normal cells. Even though are aggressive and treatment options limited, similar strategies for constrained by severe immune suppression arising from bystander aplasia. Here, we show selective killing malignant without affecting cell-mediated responses vitro a mouse model disseminated leukemia. Further, develop CAR construct that carries single chain variable fragment...
Ligilactobacillus salivarius 23-006 and Lacticaseibacillus paracasei 23-008 ameliorated rosacea-like inflammation in mice through modulation of the gut microbiota TLR2/MyD88/NF-κB pathway.
While chimeric antigen receptor-modified T (CAR-T) cells have shown great success for the treatment of B cell leukemia, their efficacy appears to be compromised in derived lymphoma and solid tumors. Optimization CAR design improve persistence cytotoxicity is a focus current CAR-T study. Herein, we established novel structure by adding full length 4-1BB co-stimulatory receptor 28Z-based second generation that targets CD20. Our data indicated this new 2028Z-4-1BB showed improved proliferation...
Genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated 9 (Cas9)-mediated loss-of-function screens are powerful tools for identifying genes responsible diverse phenotypes. Here, we perturbed in melanoma cells to screen involved tumor escape from T cell-mediated killing. Multiple interferon gamma (IFNγ) signaling-related were enriched resistant cell In addition, deletion of the deubiquitinating protease ubiquitin specific peptidase 22 (USP22) mouse...
Oxysterols are metabolites of cholesterol that regulate homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize binds to α (ERα) in brain energy balance. Supporting this view, found delivering reduced food intake and activated proopiomelanocortin (POMC) neurons arcuate nucleus hypothalamus (POMC
Neutralizing antibodies exert a potent inhibitory effect on viral entry; however, they are less effective in therapeutic models than prophylactic models, presumably because of their limited efficacy eliminating virus-producing cells via Fc-mediated cytotoxicity. Herein, we present SARS-CoV-2 spike-targeting bispecific T-cell engager (S-BiTE) strategy for controlling infection. This approach blocks the entry free virus into permissive by competing with membrane receptors and eliminates...
Fault-tolerant control (FTC) strategies have been proposed to improve the reliability of power electronic systems. However, FTC three-level T-type converter based shunt active filter (SAPF) remains limited by redundant devices. To address this problem, an strategy called sequential model predictive tolerant (SMPTC) is combined with a nonintegral lexicographic optimization (LO) algorithm for solving multiobjective problems. First, circuit, space voltage vector diagram, harmonic extraction,...
Automatic ship detection in Synthetic Aperture Radar (SAR)imagery has been playing a significant role the field of marine monitoring. But great challenges still exist real-time application. Despite exciting progress made by deep-learning techniques, most detectors failed to yield locations fairly high quality, especially for small objects under complicated background. To alleviate above problem, author proposes single-stage detector based on attention mechanism. First, we degenerate...
Objectives Setup error is a key factor affecting postmastectomy radiotherapy (PMRT) and irradiation of the internal mammary lymph nodes most investigated aspect for PMRT patients. In this study, we evaluated robustness, radiobiological, dosimetric benefits hybrid volumetric modulated arc therapy (H-VMAT) planning technique based on setup in dose accumulation using surface-guided system radiation therapy. Methods We retrospectively selected 32 patients treated by oncologist clinical target...
The emergence of the novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to pandemic coronavirus disease 2019 (COVID-19), which markedly affected global health and economy. Both uncontrolled viral replication a proinflammatory cytokine storm can cause tissue damage in patients with COVID-19. SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) as its entry receptor. In this study, we generated ACE2 extracellular domain-Fc single-chain variable...
This paper analyzed the clustering degree and spatial distribution characteristics of imported timber landing processing industry in China’s Heilongjiang province based on survey statistical data during 2019–2021. The location entropy method was used to quantify processing. Multi-distance analysis, hotspot autocorrection analysis were conducted identify pattern enterprises analyze hotspots correlation among prefecture-level cities region. Results showed that there obvious industrial...
Legg‑Calvé‑Perthes disease (LCPD) is a pediatric form of femoral head osteonecrosis with unknown etiology. MicroRNAs (miRs) have been revealed to serve an important role in LCPD. MiR‑214 serves chondrogenesis. The aim the present study was investigate potential miR‑214 LCPD and underlying mechanisms. expression levels B‑cell lymphoma 2 (Bcl‑2)‑associated X protein (Bax) dexamethasone (DEX)‑treated TC28 cells, cartilage tissues, serum primary chondrocytes patients LCPD, healthy individuals...
Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among patients. Here, our aim was to ascertain immune regulatory mechanisms involved in CRPC development and identify potential immunotherapies against CRPC.A model established using Myc-CaP cells immune-competent FVB mice following castration. The cell profile tumor microenvironment (TME) analyzed during development. Different were screened model, their efficacies underlying investigated vitro vivo.During...
In order to make a good change the system dynamic response, cut down steady-state error of follower control on type combat vehicles, model predictive (MPC) is employed propose novel current controller replace traditional vector by PI controller. To solve problem degradation performance due mismatch parameters between and actual motor during operation permanent magnet synchronous (PMSM), method using account least squares (LSM) including forgetting factor submitted in paper. The design...