A5066896791- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Hypothalamic control of reproductive hormones
- Exercise and Physiological Responses
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Sirtuins and Resveratrol in Medicine
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Dietary Effects on Health
- Hormonal Regulation and Hypertension
- Neurobiology and Insect Physiology Research
- Menopause: Health Impacts and Treatments
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
University of Illinois Chicago
2019-2025
University of Illinois Urbana-Champaign
2023
Baylor College of Medicine
2013-2022
Children's Nutrition Research Center at Baylor College of Medicine
2012-2022
Pennington Biomedical Research Center
2022
Baylor University
2022
Baton Rouge Clinic
2020
Arkansas Children's Nutrition Center
2019
Brown Foundation
2016
University of Cincinnati Medical Center
2016
Binge eating afflicts approximately 5% of US adults, though effective treatments are limited. Here, we showed that estrogen replacement substantially suppresses binge-like behavior in ovariectomized female mice. Estrogen-dependent inhibition was blocked mice specifically lacking receptor-α (ERα) serotonin (5-HT) neurons the dorsal raphe nuclei (DRN). Administration a recently developed glucagon-like peptide-1-estrogen (GLP-1-estrogen) conjugate designed to deliver GLP1 receptor-enhanced...
BackgroundNeural networks that regulate binge eating remain to be identified, and effective treatments for are limited.MethodsWe combined neuroanatomic, pharmacologic, electrophysiological, Cre-lox, chemogenetic approaches investigate the functions of 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) expressed by dopamine (DA) neurons in regulation binge-like behavior mice.ResultsWe showed 5-HT stimulates DA neural activity through a 5-HT2CR-mediated mechanism, activation this midbrain...
Article18 July 2019Open Access Transparent process Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling Tao Wang Guangdong Province Key Laboratory of Animal Nutritional Regulation, College Science, South China Agricultural University, Guangzhou, Guangdong, Search for more papers by this author Ya-Qiong Xu Ye-Xian Yuan Ping-Wen Division Endocrinology, Department Medicine, The University Illinois at Chicago, IL, USA Cha Zhang Fan Li Li-Na Cong Yin Lin Xing-Cai Cai Can-Jun...
Estrogen receptor–α (ERα) activity in the brain prevents obesity both males and females. However, ERα-expressing neural populations that regulate body weight remain to be fully elucidated. Here we showed single-minded–1 (SIM1) neurons medial amygdala (MeA) express abundant levels of ERα. Specific deletion gene encoding ERα (Esr1) from SIM1 neurons, which are mostly within MeA, caused hypoactivity male female mice fed with regular chow, increased susceptibility diet-induced (DIO) but not...
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, critical hormone energy balance. Here, we aimed identify physiological signal that arises from excess caloric intake and negatively controls leptin action. We found deficiency the gastric inhibitory polypeptide receptor (Gipr) for gut-derived incretin GIP protected against diet-induced neural resistance. Furthermore, centrally antibody neutralizes GIPR had remarkable antiobesity...
Previously, we found that α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). Here, demonstrated the beneficial effects of AKG on glucose homeostasis in a diet-induced obesity (DIO) mouse model, which are independent OXGR1. We also showed effectively decreased blood hepatic gluconeogenesis DIO mice. By using transcriptomic liver-specific
Estrogens promote binge alcohol drinking and contribute to sex differences in use disorder. However, the mechanisms are largely unknown. This study aims test if estrogens act on 5-hydroxytryptamine neurons dorsal raphe nucleus (5-HT
Abstract Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that female mice have more pro-opiomelanocortin (POMC) neurons arcuate nucleus of hypothalamus than males, and POMC display higher neural activities, compared to male counterparts. Strikingly, deletion transcription factor, TAp63, confers “male-like” diet-induced obesity (DIO) associated with decreased activities; same does not affect mice. Our results indicate TAp63 contributes...
Ghrelin signaling has major effects on energy and glucose homeostasis, but it is unknown whether ghrelin’s functions are centrally and/or peripherally mediated. The ghrelin receptor, growth hormone secretagogue receptor (GHS-R), highly expressed in the brain detectable some peripheral tissues. To understand roles of neuronal GHS-R, we generated a mouse line where Ghsr gene deleted all neurons using synapsin 1 (Syn1)-Cre driver. Our data showed that deletion abolishes ghrelin-induced...
Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these are unclear. Here we report that estrogen receptor-α (ERα)-expressing in the ventrolateral subdivision ventromedial hypothalamic nucleus (vlVMH) can sense fluctuations, being glucose-inhibited (GI-ERα
Abstract Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion SRC-1 in mice attenuates their depolarization by leptin, decreases expression increases leading high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants found severely...
Article27 February 2020Open Access Source DataTransparent process Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation Yexian Yuan Guangdong Laboratory of Lingnan Modern Agriculture, Province Key Animal Nutritional Regulation National Engineering Research Center for Breeding Swine Industry, College Science, South China Agricultural University, Guangzhou, Search more papers by this author Pingwen Xu Division Endocrinology,...
Elevations in estrogen (17β-estradiol, E2) are associated with increased alcohol drinking by women and experimentally rodents. E2 alters the activity of dopamine system, including VTA its projection targets, which plays an important role binge drinking. A previous study demonstrated that, during high states, neurons female mice more sensitive to ethanol excitation. However, mechanisms responsible for ability enhance sensitivity have not been investigated. In this study, we used selective...
Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, adipocytes quickly transition into white upon removing stimuli. Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for beige-to-white transition. Beige lacking Cdkn2a exhibit prolonged lifespan, male mice confer long-term metabolic protection from diet-induced obesity, along with enhanced energy expenditure improved glucose...
Skeletal muscle atrophy due to excessive protein degradation is the main cause for dysfunction, fatigue, and weakening of athletic ability. Endurance exercise effective attenuate atrophy, but underlying mechanism has not been fully investigated. a-Ketoglutarate (AKG) a key intermediate tricarboxylic acid cycle, which generated during endurance exercise. Here, we demonstrated that AKG effectively attenuated corticosterone-induced rescued dysfunction in Duchenne muscular dystrophy mouse model....
Adipocytes arise from distinct progenitor populations during developmental and adult stages but little is known about how progenitors differ progenitors. Here, we investigate the role of platelet-derived growth factor receptor alpha (PDGFRα) in divergent regulation two different adipose cells (APCs). Using vivo lineage tracking deletion mouse models, found that PDGFRα+ are adipogenic differentiated into mature adipocytes, Pdgfra disrupted white tissue (WAT) formation. Interestingly, do not...
Abstract Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT DRN ) regulate different types feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation 5-HT hypothalamic arcuate → ARH) projections inhibits food intake driven by via actions at ARH 2C and 1B receptors, whereas ventral tegmental...
Asprosin, a recently identified adipokine, activates agouti-related peptide (AgRP) neurons in the arcuate nucleus of hypothalamus (ARH) via binding to protein tyrosine phosphatase receptor δ (Ptprd) increase food intake. However, intracellular mechanisms responsible for asprosin/Ptprd-mediated activation AgRP