A5100373603- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- MRI in cancer diagnosis
- Protein purification and stability
- Nanoplatforms for cancer theranostics
- Renal cell carcinoma treatment
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Virus-based gene therapy research
- Ultrasound Imaging and Elastography
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Photoacoustic and Ultrasonic Imaging
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cardiovascular Function and Risk Factors
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Imaging Techniques and Applications
- Electrocatalysts for Energy Conversion
Shanghai Changzheng Hospital
2023-2025
Hunan Normal University
2023-2025
Huazhong University of Science and Technology
2010-2024
Shanghai Jiao Tong University
2015-2024
Shanghai First People's Hospital
2015-2024
Nanjing Medical University
2015-2024
Institute of Electronics
2024
Jiangsu Province Hospital
2021-2024
Daping Hospital
2020-2024
Army Medical University
2013-2024
Synergistic therapeutic strategies for bacterial infection have attracted extensive attentions owing to their enhanced effects and less adverse compared with monotherapy. Herein, we report a novel synergistic antibacterial platform that integrates the nanocatalytic therapy photothermal (PTT) by hemoglobin-functionalized copper ferrite nanoparticles (Hb-CFNPs). In presence of low concentration hydrogen peroxide (H2O2), excellent Fenton Fenton-like reaction activity Hb-CFNPs can effectively...
The molecular link between obesity and β cell failure that causes diabetes is difficult to establish. Here we show a conditional knockout of insulin receptor substrate 2 (Irs2) in mouse pancreas cells parts the brain — including hypothalamus —increased appetite, lean fat body mass, linear growth, resistance progressed diabetes. Diabetes resolved when mice were 6 10 months age: functional expressing Irs2 repopulated pancreas, restoring sufficient function compensate for obese mice. Thus,...
In spite of recent advances in diagnostic and therapeutic measures, the prognosis hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved promoting development HCC. Evidence accumulating that members chemokine receptor family viewed as promising targets fight against cancer. More studies have revealed CXCR7 plays an important role cancer development. However, little known about effect on process HCC cell invasion angiogenesis....
Conventional chemotherapy of pancreatic cancer (PaCa) suffers the problems low drug permeability and inherent or acquired resistance. Development new strategies for enhanced therapy still remains a great challenge. Herein, we report ultrasound-targeted microbubble destruction (UTMD)-promoted delivery system based on dendrimer-entrapped gold nanoparticles (Au DENPs) co-delivery gemcitabine (Gem) miR-21 inhibitor (miR-21i).
Inspired by the chain reactions among silver nanoparticles, glucose oxidase (GOx) and intratumoral glucose, a degradable silver-based nanoplatform was developed for synergistic cancer starving-like/metal ion therapy.
Amygdalin, a naturally occurring substance, has been suggested to be efficacious as an anticancer substance. The effect of amygdalin on cervical cancer cells never studied. In this study, we found that the viability human HeLa cell line was significantly inhibited by amygdalin. 4,6-Diamino-2-phenyl indole (DAPI) staining showed amygdalin-treated developed typical apoptotic changes. development apoptosis in were confirmed double with annexin V-FITC and propidium iodide (PI) along increase...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies and rapidly progressive diseases. Exosomes long noncoding RNAs (lncRNAs) are emerging as vital mediators in tumor cells their microenvironment. However, detailed roles mechanisms exosomal lncRNAs PDAC progression remain unknown. Here, we aimed to clarify clinical significance lncRNA 01133 (LINC01133) PDAC. We analyzed expression LINC01133 found that was high positively correlated with higher TNM stage poor...
Abstract Background Dyslipidemia is one of independent risk factors for coronary atherosclerotic heart disease (CAHD). We determined whether the LDL/HDL ratio better than LDL-C or HDL-C alone in predicting severity CAHD. Methods performed a retrospective study 1351 patients with myocardial ischemia who underwent angiography between January 2018 and December 2019 Shanghai Ninth People’s Hospital. Spearman correlation analysis, logistic regression model, Cox proportional hazards model...
Fungi inhabit different anatomic sites in the human body. Advances omics analyses of host‑microbiome interactions have tremendously improved our understanding effects fungi on health and diseases such as tumors. Due to significant enrichment specific patients with malignant tumors, associations between cancer attracted an increasing attention recent years. Indeed, type‑specific fungal profiles been found tumor tissues. Importantly, also influence tumorigenesis through multiple factors, host...
The association between secondhand smoke (SHS) and risk of peripheral arterial disease (PAD) stroke remains uncertain. We examined the relationship SHS cardiovascular diseases, particularly PAD stroke, in Chinese women who never smoked from a population-based cross-sectional study Beijing, China. exposure was defined as to another person's tobacco at home or workplace. Cardiovascular events included coronary heart disease, PAD. by signs intermittent claudication measured World Health...
The link between maternal under-nutrition and cardiovascular disease (CVD) in the offspring later life is well recognized, but impact of over-nutrition on offspring's function subsequent risk for CVD remains unclear. Here, we investigated exposure to a high-fat/calorie diet (HFD) during pregnancy early postnatal period endothelial nonhuman primate model. Offspring, naturally born either control (CTR) (14% fat calories) or HFD (36% consumption dam, were breast-fed until weaning at about 8...
Gastric cancer is one of the most prevalent and aggressive cancers worldwide, its molecular mechanism remains largely elusive. Here we report genomic landscape in primary gastric adenocarcinoma human, based on complete genome sequences five pairs matching normal samples. In total, 103,464 somatic point mutations, including 407 nonsynonymous ones, were identified recurrent mutations harbored by Mucins (MUC3A MUC12) transcription factors (ZNF717, ZNF595 TP53). 679 rearrangements detected,...
Objective This study aimed to develop targeted cationic microbubbles conjugated with a CD105 antibody (CMB105) for use in vascular endothelial cell gene therapy and ultrasound imaging.We compared the results untargeted (CMB) neutral (NMB).Methods CMB105 were prepared CMB NMB.First, characterized terms of size, zeta-potential, binding ability plasmid DNA loading capacity.A tumor model subcutaneous breast cancer nude mice was used our experiments.The different types target HUVECs vitro...
The serine/threonine kinase IL-1R-associated (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, potent, highly selective inhibitor IRAK4 activity that demonstrates equipotent against multiple MyD88-dependent responses both in vitro and vivo. BMS-986126 failed to inhibit assays downstream MyD88-independent receptors, including the TNF receptor TLR3. Very little was seen TLR4, which can also activate an pathway. In mice, compound inhibited cytokine production...
Article27 February 2020Open Access Source DataTransparent process Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation Yexian Yuan Guangdong Laboratory of Lingnan Modern Agriculture, Province Key Animal Nutritional Regulation National Engineering Research Center for Breeding Swine Industry, College Science, South China Agricultural University, Guangzhou, Search more papers by this author Pingwen Xu Division Endocrinology,...
Platycodin D (PLD) is a saponin found in Platycodon grandiflorum, which has been reported to have anti-inflammatory effects. However, the effects of PLD on ulcerative colitis (UC) remain unknown. In this study, showed potential reduce inflammation, ameliorate intestinal damage, and maintain integrity DSS-induced colitis. beneficial effect was reduced when macrophages were depleted, indicating key role Meanwhile, we that inhibited expression M1 markers promoted M2 colon. Similarly,...
The performance of a proton exchange membrane electrolyzer is greatly affected by the interfacial contact between porous transport layer and catalyst layer. Microporous layers have been widely used in fuel cells but less studied for water electrolysis. In this study, incorporated with microporous are developed using phase inversion/vacuum sintering method. Characterizations show that uniformly cover surface titanium felt without significantly changing its porosity. After vacuum sintering,...