A5103199355- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Tannin, Tannase and Anticancer Activities
- Nuclear Receptors and Signaling
- Bone Metabolism and Diseases
- Morinda citrifolia extract uses
- Chemokine receptors and signaling
- Advanced Radiotherapy Techniques
- Thyroid Cancer Diagnosis and Treatment
- Kruppel-like factors research
- Pregnancy-related medical research
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2025
Chongqing Medical University
2013-2025
Jiangmen Wuyi Traditional Chinese Medicine Hospital
2024
Molecular Oncology (United States)
2020
Chongqing University
2015
Ruijin Hospital
2015
Harbin Medical University
2015
Zhejiang Cancer Hospital
2015
China Medical University
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
In spite of recent advances in diagnostic and therapeutic measures, the prognosis hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved promoting development HCC. Evidence accumulating that members chemokine receptor family viewed as promising targets fight against cancer. More studies have revealed CXCR7 plays an important role cancer development. However, little known about effect on process HCC cell invasion angiogenesis....
Abstract The limited infiltration of CD8+ T cells in tumors hampers the effectiveness cell–based immunotherapy, yet mechanisms that limit tumor by remain unclear. Through bulk RNA sequencing human tumors, we identified a strong correlation between WNT7A expression and reduced T-cell infiltration. Further investigation demonstrated inhibiting substantially enhanced MHC-I on cells. Mechanistically, inhibition inactivated Wnt/β-catenin signaling pathway thus resulted physical interaction...
<p>Figure S3 WNT7A blockage inhibits tumor growth and enhances anti-tumor immunity.</p>
<p>Figure S6 Discovery of small chemical inhibitors targeting WNT7A–FZD5.</p>
<p>Figure S4 Inhibition of WNT7A leads to the upregulation MHC-I via NF-κB pathway.</p>
<p>Figure S2 Blocking WNT7A leads to an increase in MHC-I expression.</p>
<div>Abstract<p>The limited infiltration of CD8<sup>+</sup> T cells in tumors hampers the effectiveness cell–based immunotherapy, yet mechanisms that limit tumor by remain unclear. Through bulk RNA sequencing human tumors, we identified a strong correlation between WNT7A expression and reduced T-cell infiltration. Further investigation demonstrated inhibiting substantially enhanced MHC-I on cells. Mechanistically, inhibition inactivated Wnt/β-catenin signaling pathway...
<p>Figure S5 Blocking WNT7A synergizes with ICB.</p>
<p>Figure S1 High WNT7A expression correlates with low CTL cell infiltration, reduced MHC-I expression, and unfavorable patient survival.</p>
<p>Figure S7 1,365-0,109 improves ICB efficacy without significant toxic side effects.</p>
REGγ is a proteasome activator that facilitates the degradation of small peptides. Abnormally high expression has been observed in thyroid carcinomas. The purpose present study was to explore role poorly differentiated carcinoma (PDTC). For this purpose, interfering RNA (siRNA) introduced down-regulate level PDTC cell line SW579. Down-regulation at mRNA and protein levels confirmed by RT-PCR Western blot analyses. FACS analysis revealed cycle arrest G1/S transition, MTT assay showed...
The recently available guidelines on the management of advanced breast cancer (ABC) organized by Chinese Anti-Cancer Association, Committee Breast Cancer Society (CACA-CBCS) do not elucidate ABC in details. To instruct clinicians treatment ABC, a expert consensus meeting diagnosis and was held June 2014 is developed. following provides level evidence supporting documents for each recommendation, introduces research topics to be urgently addressed. Notably, China developed applied nationwide....
Because of its insensitivity to existing radiotherapy, namely, chemotherapy and targeted treatments, triple-negative breast cancer (TNBC) remains a great challenge overcome. Increasing evidence has indicated abnormal Wnt/β-catenin pathway activation in TNBC but not luminal or HER2+ cancer, lncRNAs play key role variety cancers. Through lncRNA microarray profiling between activated inactivated tissues, lnc-WAL (Wnt/β-catenin-associated lncRNA; WAL) was selected as the top upregulated compared...
Osteoarthritis (OA) is a degenerative joint disorder characterized by progressive cartilage degradation. Excessive oxidative stress (OS), inflammatory responses, extracellular matrix breakdown, and cellular senescence of chondrocytes play crucial roles in the pathological development OA. Currently, curing OA remains significant challenge. In this study, we aimed to elucidate protective effects Annexin A1 protein Mimetic Peptide (Ac2-26) against tumor necrosis factor-α (TNF-α)-induced damage...
Intra‑arterial infusion chemotherapy for locally advanced breast cancer (LABC) has been previously performed. However, the main complications of this type remain to be clarified. In present study, catheterization was carried out 53 LABC cases (stage Ⅲa-Ⅲc) between May, 2006 and March, 2007. For ⅢB ⅢC patients, catheters were guided opening subclavian artery. stage Ⅲa placed into thoracic artery through a subcutaneous femoral puncture. One four cycles (mean, 1.6 cycles) administered patients...
The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor in variety of cancers, including breast cancer. Reduced WWOX expression associated with the basal-like subtype and relatively poor disease-free survival rate among cancer patients. Though several partners have been identified, functional mechanisms WWOX's role cancers not fully addressed to date. In current study, we found suppresses KLF5-an oncogenic transcription factor-at protein level, cell proliferation both bladder...
<p>lnc-WAL promotes malignant progression of TNBC cells.</p>
<p>lnc-WAL inhibits β-catenin phosphorylation by physically obstructing AXIN.</p>
<p>Univariate and multivariate Cox proportional hazard analyses of OS in 189 patients with TNBC.</p>