The synthesis of water-soluble nitrogen-doped carbon dots has received great attention, due to their wide applications in oxygen reduction reaction, cell imaging, sensors, and drug delivery. Herein, nitrogen-doped, carbon-rich, highly photoluminescent have been synthesized for the first time from ammonium citrate under hydrothermal conditions. obtained possess bright blue luminescence, short fluorescence lifetime, pH-sensitivity excellent stability at a high salt concentration. They...

Developing bifunctional efficient and durable non-noble electrocatalysts for oxygen evolution reaction (OER) hydrogen (HER) is highly desirable challenging overall water splitting. Herein, Co-Mn carbonate hydroxide (CoMnCH) nanosheet arrays with controllable morphology composition were developed on nickel foam (NF) as such a electrocatalyst. It discovered that Mn doping in CoCH can simultaneously modulate the to significantly increase electrochemical active surface area exposing more...

N-doped carbon dots by heterogeneous synthesis under microwave irradiation have been applied with solid and aqueous states.

Constructing catalysts with new and optimizational chemical components structures, which can operate well for both the anodic oxygen evolution reaction (OER) cathodic hydrogen (HER) at large current densities, is of primary importance in practical water splitting technology. Herein, NiFe2O4 nanoparticles/NiFe layered double hydroxide (LDH) nanosheet heterostructure array on Ni foam was prepared via a simple one-step solvothermal approach. The as-prepared displays high catalytic activity...

Abstract Carbon dots (CDs), as a new member of carbon nanomaterial family, have aroused great interest since their discovery in 2004. Because outstanding water solubility, high sensitivity and selectivity to target analytes, low toxicity, favorable biocompatibility, excellent photostability, researchers from diverse disciplines come together further develop the fundamental properties CDs. Many methods for production CDs been reported, therein, hydrothermal solvothermal technology needs...

An Fe-doped NiSe nanorod/nanosheet hierarchical array on Ni foam is constructed for efficient overall water splitting.

A facile strategy is presented to form 3D porous Cu@Cu2 O aerogel networks by self-assembling nanoparticles with the diameters of ca. 40 nm for constructing catalytic interfaces. Unexpectedly, prepared display excellent electrocatalytic activity glucose oxidation at a low onset potential 0.25 V. Moreover, aerogels also can act as mimicking-enzymes including horseradish peroxidase and NADH peroxidase, show obvious enzymatic activities dopamine (DA), o-phenyldiamine (OPD),...

Defect-rich MoS₂ultrathin nanosheets with abundant unsaturated sulfur atoms are constructed for high performance in lithium-ion batteries and supercapacitors.

A Co-doped NiO/NiFe₂O₄ mesoporous nanosheet array on Ni foam is constructed for highly efficient overall water splitting.

A unique, sensitive, and highly specific fluoroimmunoassay system for antigen detection using gold magnetic nanoparticles has been developed. The assay is based on the fluorescence quenching of fluorescein isothiocyanate caused by coated with monoclonal antibody. To demonstrate its analytical capabilities, were anti-alpha-fetoprotein polyclonal antibodies, which specifically bound alpha-fetoprotein. Gold antibodies could sandwich alpha-fetoprotein captured nanoparticle probes. sandwich-type...

Conventional chemotherapy of pancreatic cancer (PaCa) suffers the problems low drug permeability and inherent or acquired resistance. Development new strategies for enhanced therapy still remains a great challenge. Herein, we report ultrasound-targeted microbubble destruction (UTMD)-promoted delivery system based on dendrimer-entrapped gold nanoparticles (Au DENPs) co-delivery gemcitabine (Gem) miR-21 inhibitor (miR-21i).

Utilization of carbon nanodots (CNDs), newcomers to the world carbonaceous nanomaterials, in electrochemistry realm has rarely been reported so far. In this study, CNDs were used as immobilization supports and electron carriers promote direct transfer (DET) reactions glucose oxidase (GOx) bilirubin (BOD). At electrode entrapped with GOx, a high rate constant (k(s)) 6.28 ± 0.05 s(-1) for fast DET an apparent Michaelis-Menten (K(M)(app)) low 0.85 0.03 mM affinity found. By taking advantage its...

Down to the bare bones: When a glucose oxidase (GOx, left) was deglycosylated, modified enzyme (right) immobilized on vitreous carbon electrode came into closer electrical contact with surface than native enzyme. Glucose electrooxidized directly monolayer of deglycosylated GOx at unprecedented reducing potential −200 mV versus Ag/AgCl and current density 235 μA cm−2.

ConspectusThe use of protein to precisely manipulate cell signaling is an effective approach for controlling fate and developing precision medicine. More recently, programmable nucleases, such as CRISPR/Cas9, have shown extremely high potency editing genetic flow mammalian cells, treating disorders. The therapeutic potential proteins with intracellular target, however, mostly challenged by their low impermeability. Therefore, a delivery system transport the site action in spatiotemporal...

Abstract The development of cost‐effective and applicable strategies for producing efficient oxygen evolution reaction (OER) electrocatalysts is crucial to advance electrochemical water splitting. Herein, a kinetically controlled room‐temperature coprecipitation developed as general strategy produce variety sandwich‐type metal hydroxide/graphene composites. Specifically, well‐defined α‐phase nickel cobalt hydroxide nanosheets are vertically assembled on the entire graphene surface...

Many metal–organic frameworks have been designed and synthesized for biosensors because of high surface area porosity, suitable size, good biocompatibility. Despite recent advances, however, most them are only used as a nanocarrier. In this work, new artificial nanozyme was constructed on metalloporphyrinic framework (PMOF(Fe)), which formed by Fe porphyrin Zr4+ ions. Then, ultrasmall Pt nanoparticles (Pt NPs) were loaded the PMOF(Fe) to form Pt@PMOF(Fe). Because exposed activity center,...

Theranostic formulations, integrating both diagnostic and therapeutic functions into a single platform, hold great potential for precision medicines. In this work, biodegradable theranostic based on hollow mesoporous organosilica nanoparticles (HMONs) is reported explored ultrasound/photoacoustic dual-modality imaging guided chemo-photothermal therapy of cancer. The HMONs prepared are endowed with glutathione-responsive biodegradation behavior by incorporating disulfide bonds their...

The dense extracellular matrix (ECM) and hypovascular networks were often found in solid pancreatic tumors form an impenetrable barrier, leading to limited uptake of chemotherapeutics thus undesirable treatment outcomes. Methods: A biodegradable nanoplatform based on hollow mesoporous organosilica nanoparticle (HMON) was designed as effective delivery system for pirfenidone (PFD) overcome the challenges tumor treatment. By varying pH producing a mildly acidic environment emulate cells,...