A5058815529- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- T-cell and Retrovirus Studies
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Electrocatalysts for Energy Conversion
- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
First Affiliated Hospital Zhejiang University
2016-2025
Peking University
2024
Fuzhou University
2024
Zhujiang Hospital
2024
Southern Medical University
2024
Nanfang Hospital
2024
Zhejiang University
2006-2023
Blood Center of Zhejiang Province
2018-2023
Zhejiang Cancer Hospital
2021-2023
Hangzhou Cancer Hospital
2023
Constructing catalysts with new and optimizational chemical components structures, which can operate well for both the anodic oxygen evolution reaction (OER) cathodic hydrogen (HER) at large current densities, is of primary importance in practical water splitting technology. Herein, NiFe2O4 nanoparticles/NiFe layered double hydroxide (LDH) nanosheet heterostructure array on Ni foam was prepared via a simple one-step solvothermal approach. The as-prepared displays high catalytic activity...
An Fe-doped NiSe nanorod/nanosheet hierarchical array on Ni foam is constructed for efficient overall water splitting.
A Co-doped NiO/NiFe<sub>2</sub>O<sub>4</sub> mesoporous nanosheet array on Ni foam is constructed for highly efficient overall water splitting.
Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis platelet function. Recently, α-actinin-1 mutations have been reported patients with congenital macrothrombocytopenia. However, the role underlying mechanism of function remain elusive. Using MK-specific knockout (PF4-Actn1-/-) mice, we demonstrated that PF4-Actn1-/- mice exhibited reduced counts. The decreased number was due to defects thrombocytopoiesis. H&E staining flow cytometry...
Axon growth is tightly controlled to establish functional neural circuits during brain development. Despite the belief that cytoskeletal dynamics critical for cell morphology, how microtubule acetylation regulates axon development in mammalian central nervous system remains unclear. Here, we report loss of α-tubulin by ablation MEC-17 mice predisposes neurons overbranching and overgrowth. Introduction MEC-17F183A lacking acetyltransferase activity into MEC-17-deficient failed rescue defects....
PARP-1 plays a critical role in DNA damage repair and contributes to progression of cancer. To explore the acute myeloid leukemia (AML), we analyzed expression AML its relation clinical prognosis. Then, investigated efficacy mechanism PARP inhibitor BMN673 (Talazoparib) combined with NL101, novel SAHA-bendamustine hybrid vitro vivo.The 339 cytogenetically normal (CN-AML) cases was evaluated using RT-PCR. According PARP-1, characteristics prognosis patients were grouped compared. The...
The aim of this study was to investigate the characteristics immune function monocytes in different stages patients with acute on chronic liver failure (ACLF). Human leucocyte antigen (HLA)-DR and Toll-like receptor 4 (TLR-4) expression early late were detected by flow cytometry. secretion measured cytometric bead array. Compared healthy controls, levels HLA-DR hepatitis B, cirrhosis gradually decreased, especially stage (P < 0.001). TLR-4 higher than controls. concentrations interleukin...
Thrombosis and hemostasis take place in flowing blood, which generates shear forces. The effect of different rates, particularly pathological forces, on platelet thrombus formation remains to be fully elucidated. present study observed the morphological characteristics hierarchical structure thrombi collagen surface at a wide range wall rates (WSRs) examined underlying mechanisms. Calcein AM‑labeled whole blood was perfused over collagen‑coated set by Bioflux 200 microfluidic device formed...
Ten-Eleven-Translocation 1 (TET1) plays a role in the DNA methylation process and gene activation. Recent reports suggest TET1 acts as an oncogene leukemia development. However, clinical relevance biological insight of expression cytogenetically normal acute myeloid (CN-AML) is unknown. In this study, quantification transcript by real-time quantitative PCR bone marrow blasts was performed 360 CN-AML patients. As result, high more common M0/M1 morphology genes NPM1 mutations, underrepresented...
Aberrant metabolism is a hallmark of cancer cells. Recently, ATP citrate-lyase (ACLY) expression was demonstrated as an independent predictor clinical outcome in solid tumors. However, no systematic study conducted to explore the prognostic impact ACLY on acute myeloid leukemia (AML).To assess value transcript, we with discovery and validation design. We measured transcript by real-time quantitative PCR 274 AML patients, validated two cohorts using published data. Meta-analysis...
Abstract Background Spermatogenesis associated serine rich 2 like (SPATS2L) was highly expressed in homoharringtonine (HHT) resistant acute myeloid leukemia (AML) cell lines. However, its role is little known AML. The present study aimed to investigate the function of SPATS2L AML pathogenesis and elucidate underlying molecular mechanisms. Methods Overall survival (OS), event-free (EFS), relapse-free (RFS) were used evaluate prognostic impact for from TCGA database ourcohort. ShRNA knockdown...
Abstract Background Fatty acid oxidation (FAO) provides an important source of energy to promote the growth leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme essential step FAO, can facilitate cancer metabolic adaptation. Previous reports demonstrated that CPT1a acts as potential molecular target in solid tumors and hematologic disease. However, no systematic study was conducted explore prognostic value expression possible treatment strategies with inhibitor on...
Summary Glutamine metabolic reprogramming in acute myeloid leukaemia (AML) cells contributes to the decreased sensitivity antileukemic drugs. Leukaemic cells, but not their counterparts, largely depend on glutamine. Glutamate dehydrogenase 1 (GDH1) is a regulation enzyme glutaminolysis. However, its role AML remains unknown. Here, we reported that GDH1 was highly expressed AML: high one of independent negative prognostic factors cohort. The dependence leukaemic proved both vitro and vivo....
BACKGROUND: The interest in plasma biomarkers has increased recently. Plasma exosome-derived microRNA-532 is aberrantly expressed a variety of human cancers and the prognostic value many solid tumors. However, impact expression on AML remains unclear. OBJECTIVE : aim this study to investigate patients. METHODS: We performed real-time PCR quantify 198 To assess value, we Cox regression analyses context well-established clinical molecular markers. Cellular metabolic profile was conducted help...
Although there are many clinical and molecular biomarkers in acute myeloid leukemia (AML), the novel reliable still required to predict overall survival at time of disease diagnosis.In order identify independent predictors, we firstly selected 60 cytogenetically normal AML (CN-AML) patients using propensity score analysis balance confounders performed circular RNA (circRNA) sequencing. Next, one outcome related circRNA was validated cohort 218 CN-AML patients. We then constructed...
Long intergenic noncoding RNAs (lincRNAs) are critical regulators involved in diverse biological processes. However, the roles and related mechanisms of lincRNAs axon development largely unknown. Here we report an axon-enriched lincRNA regulating elongation, referred to as ALAE. Profiling highly expressed detected abundant enriched ALAE axons dorsal root ganglion (DRG) neurons, where it locally promoted elongation. Mechanically, directly interacted with KH3–4 domains KH-type splicing...