A5041618632- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Chronic Lymphocytic Leukemia Research
- Microbial Metabolites in Food Biotechnology
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- RNA regulation and disease
- Aeroelasticity and Vibration Control
- Structural Health Monitoring Techniques
- Phytochemicals and Antioxidant Activities
- Microbial Metabolism and Applications
- Monoclonal and Polyclonal Antibodies Research
- Nutrition, Genetics, and Disease
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Seed and Plant Biochemistry
- interferon and immune responses
- Viral-associated cancers and disorders
- Acoustic Wave Phenomena Research
- Genetic Mapping and Diversity in Plants and Animals
- Food composition and properties
First Affiliated Hospital Zhejiang University
2023-2025
Shanghai East Hospital
2025
Guangxi Hydraulic Power Machinery Research Institute
2025
Jiangsu University of Technology
2025
Seoul National University
2024
Zhejiang University
2022-2024
Shenyang Agricultural University
2024
Zhejiang Cancer Hospital
2022-2023
Abstract The COVID-19 outbreak caused by SARS-CoV-2 in late 2019 has spread rapidly across the world to form a global epidemic of respiratory infectious diseases. Increased investigations on diagnostic tools are currently implemented assist rapid identification virus because mass and diagnosis might be best way prevent virus. This critical review discusses detection principles, fabrication techniques, applications with three categories: nuclear acid augmentation test, immunoassay test...
Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis platelet function. Recently, α-actinin-1 mutations have been reported patients with congenital macrothrombocytopenia. However, the role underlying mechanism of function remain elusive. Using MK-specific knockout (PF4-Actn1-/-) mice, we demonstrated that PF4-Actn1-/- mice exhibited reduced counts. The decreased number was due to defects thrombocytopoiesis. H&E staining flow cytometry...
Abstract Flavonoids can promote lipid metabolism and prevent obesity. FH03F is a probiotic fermented plant beverage that rich in flavonoids, but its antiobesity mechanism not clear. This study aimed to explore the differences flavonoids after fermentation potential via metabolomics, network pharmacology molecular docking. Metabolomics analysis revealed significant changes fermentation, 91 were detected. Through pharmacology, 28 met efficacious screening criteria, 4 targets core targets....
This study investigated the effects of seven processing methods on structure and functional properties soluble dietary fiber (SDF) from tartary buckwheat bran, included microwave radiation, high-pressure steam, Aspergillus niger fermentation, Trichoderma viride combinations these with radiation. The results showed that microwave-assisted fermentation (MA-S) was most effective method for improving SDF, significantly increased SDF content. Scanning electron microscopy revealed MA-S-treated had...
In recent years, surface ozone (O3) pollution has emerged as a significant barrier to the continued improvement of air quality in China, making O3 risk assessment critical research priority. Using nationwide monitoring data, this investigated spatial characteristics and assessed its potential impacts on human health crop yields. The results showed that maximum daily 8 h average (MDA8 O3) exhibited higher concentrations eastern northern regions, lower western southern regions China. Long-term...
Abstract Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate progression. Here, we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues, tumors, cell lines to establish a comprehensive transcriptomic atlas. It is of note receptor tyrosine kinases were one most dynamic components with highly variable transcript, Erb-B2 kinase 2 (ERBB2) as prime representative. A designated ERBB2 i14e,...
Summary Glutamine metabolic reprogramming in acute myeloid leukaemia (AML) cells contributes to the decreased sensitivity antileukemic drugs. Leukaemic cells, but not their counterparts, largely depend on glutamine. Glutamate dehydrogenase 1 (GDH1) is a regulation enzyme glutaminolysis. However, its role AML remains unknown. Here, we reported that GDH1 was highly expressed AML: high one of independent negative prognostic factors cohort. The dependence leukaemic proved both vitro and vivo....
Abstract Background Identifying therapeutic targets and prognostic biomarkers significantly contributes to individualized treatment of acute myeloid leukemia (AML). Dihydropyrimidinase‐like 2 (DPYSL2) expression was decreased in homoharringtonine (HHT)‐resistant AML cells, which were established by our group. DPYSL2 plays an important role axon growth has oncogene effect glioblastoma. However, little research been conducted investigate the function pathogenesis. Methods Auto‐docking used...
Investigating the intricate pathways through which FH06 fermentation broth exerts lipid-lowering and weight-loss effects is pivotal for advancing our comprehension of metabolic regulation therapeutic interventions. Ultrahigh-performance liquid chromatography quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-QE-MS) detection ChEMBL database were used to determine effective compounds in predict their targets. The TTD DisGeNET query obesity-related STRING was construct protein...
Obesity is a chronic disease that profoundly impacts human health, and the role of plant-based formulas (PBFs) in combating obesity has garnered significant interest. Studies have revealed fermentation significantly enhances taste, aroma, quality, health benefits PBF water extract, with pasteurization being preferred sterilization technology. However, few studies investigated effects on active components potential functions extract broth. To examine impact fermented Millettia speciosa Champ...
Summary Large amounts of azurophilic granules are considered to be a morphological feature acute promyelocytic leukaemia (APL). However, small percentage myeloid (AML) patients also have large number granules. A cohort 3210 AML in our hospital was screened identify who had The clinical parameters these were collected and compared with typical (control Group 1) APL 2). incidence 1.26%. fibrinogen D‐dimer levels the study group more similar those control 2, as bleeding events. Additionally,...
Liaoning cashmere goat (LCG) is the world's highest producing white goat. It has characteristics of long fiber, high net rate, moderate fineness, cashmere, strong size, adaptability, stable genetic performance, and good effect in improving middle low production known as "National treasure China". With LCG paternal parent, five new local breeds have been cultivated, which made outstanding contributions to improvement breeding Chinese breeds. fineness (the average population about 16...