A5100768033- Protein Hydrolysis and Bioactive Peptides
- Algal biology and biofuel production
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Fungal Biology and Applications
- Biochemical effects in animals
- Aquaculture Nutrition and Growth
- Gut microbiota and health
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Insect Utilization and Effects
- Enzyme Catalysis and Immobilization
- Genomics, phytochemicals, and oxidative stress
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Mercury impact and mitigation studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Biochemical Analysis and Sensing Techniques
- Bioinformatics and Genomic Networks
- Meat and Animal Product Quality
- Dye analysis and toxicity
- Neuropeptides and Animal Physiology
Zhejiang University
2015-2024
First Affiliated Hospital Zhejiang University
2019-2024
South China University of Technology
2014-2024
Beike Biotechnology (China)
2023-2024
Yanbian University
2003-2024
The University of Texas Southwestern Medical Center
2017
Chinese Center For Disease Control and Prevention
2015
Columbia University
2014
Infinitus (China)
2012
Northwest A&F University
2010
In this study, a new heteropolysaccharide, here called L2, was separated from the fruit body of Lentinula edodes. Chemical and physical analyses indicated that L2 has molecular weight 26 KDa consists glucose (87.5%), galactose (9.6%), arabinose (2.8%), but it does not possess triple-helical conformation. Stimulation production nitric oxide (NO), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) in RAW 264.7 cells showed significant immune activities involving toll-like receptor 2 (TLR2)....
Chlorella pyrenoidosa is a unicellular green algae and has been popular foodstuff worldwide. However, no reports on the antitumor peptides from such microalgae are available in literature. In this study, using low-temperature high-pressure extraction, enzymatic hydrolysis, ion exchange, gel filtration chromatography, we separated polypeptide that exhibited inhibitory activity human liver cancer HepG2 cells, named CPAP (C. polypeptide). Furthermore, micro- nanoencapsulation of were...
Lentinula edodes-derived polysaccharides possess many therapeutic characteristics, including anti-tumor and immuno-modulation. The gut microbes play a critical role in modulation of immune function. However, the impact on have not yet been explored. In this study, high-throughput pyrosequencing technique was employed to investigate effects new heteropolysaccharide L2 from edodes microbiota diversity composition small intestine, cecum, colon distal end (feces) mice. results demonstrated that...
Spirulina platensis is an excellent source of proteins (>60%) that can be hydrolyzed into bioactive peptides.In this study, whole were extracted and using three gastrointestinal endopeptidases (pepsin, trypsin chymotrypsin). Subsequently, gel filtration chromatography was employed to separate hydrolysates, four fractions (Tr1-Tr4) obtained. Among them, Tr2 showed the strongest anti-proliferation activities on cancer cells (MCF-7, HepG-2 SGC-7901), with IC50 values <31.25, 36.42 48.25 µg mL-1...
A<italic>Lentinula edodes</italic>-derived heteropolysaccharide L2 can partly reverse the age-altered composition of gut microbiota.