A5100715718- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Intracranial Aneurysms: Treatment and Complications
- Helicobacter pylori-related gastroenterology studies
- Anesthesia and Neurotoxicity Research
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Bacterial Identification and Susceptibility Testing
- Cardiac Ischemia and Reperfusion
- Enterobacteriaceae and Cronobacter Research
- Cancer, Hypoxia, and Metabolism
- Biochemical effects in animals
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Redox biology and oxidative stress
- Plant-based Medicinal Research
- RNA modifications and cancer
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Qujing Normal University
2019-2025
Xinjiang Agricultural University
2025
Air Force Medical University
2022-2024
Shandong University
2023-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2015-2024
Zhejiang University
2015-2024
Sichuan University
2016-2024
West China Hospital of Sichuan University
2020-2024
The emergence and spread of carbapenem-resistant hypervirulent Klebsiella pneumoniae sequence type 11 (ST11-CR-HvKP) in China are a great concern the public health community. However, underlying mechanism that enables its wide dissemination remains unclear. Here, we investigated prevalence carriage carbapenemase-producing Enterobacteriaceae (CPE) among inpatients with diarrhea teaching hospital over 1 year to identify ST11-CR-HvKP reservoirs understand genetic background plasmid profiles...
Depression is a frequent and serious comorbidity associated with diabetes which adversely affects prognosis quality of life. Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used in the treatment diabetes, are reported to exert neuroprotective effects central nervous system. Thus, we aim evaluate whether GLP-1R agonist exendin-4 (EX-4) could alleviate depression-like behaviors diabetic mice explore its underlying mechanism. The antidepressant EX-4 were evaluated using behavioral...
Significance Oncogenic hotspot mutations in PIK3CA or RAS and overexpression of Her2 are known as a driving force for human cancer development. We others have shown that ΔNp63α, the major protein isoform p53-related p63 expressed epithelial cells, functions an important regulator cell adhesion program is critical inhibitor metastasis. In this study, we demonstrate oncogenic p110α H1047R , K-Ras G12V H-Ras use common Akt1-FOXO3a pathway suppression ΔNp63α expression and, consequently, promote...
Abstract Circular RNA s (circ s) have been demonstrated to be involved in various biological processes. Nevertheless, the function of circ medulloblastoma ( MB ) is still unknown. The present study aimed investigate expression profiles and related mechanisms for regulating proliferation growth tumor cells . were screened from four normal cerebellum samples using a HiSeq Sequencer. Bioinformatic analysis was employed predict interaction between mRNA Subsequently, levels eight differential...
Circular RNAs (circRNAs) are widely expressed non-coding in eukaryotic cells, involved regulating tumorigenesis of several types cancers. However, the expression profiles and precise functional role glioblastoma remain unclear.Circ-EPB41L5 was downregulated tissues cell lines compared to normal brain lines. Low circ-EPB41L5 correlated poor prognosis patients, while overexpression inhibited proliferation, clone formation, migration, invasion abilities glioma suppression had counter effects....
Organoids are three-dimensional structures that closely recapitulate tissue architecture and cellular composition, thereby holding great promise for organoid-based drug screening. Although growing in provides the possibility organoids to main features of corresponding tissues, it makes incommodious imaging two-dimensional identifying surviving from surrounding dead cells after being treated by irradiation or chemotherapy. Therefore, significant work remains establish high-quality controls...
Complex mechanisms participate in microglial activation after a traumatic brain injury (TBI). TBI can induce autophagy and apoptosis neurons glial cells, moderate hypothermia plays protective role the acute phase of TBI. In present study, we evaluated effect on investigated possible roles autophagy/apoptosis toll-like receptor 4 (TLR4).The model was induced with fluid percussion device. Moderate achieved under general anesthesia by partial immersion water bath for h. All rats were killed 24...
Sirt5 (Sirtuin 5) desuccinylates multiple metabolic enzymes and plays an important role in maintaining energy homeostasis. The goal of this study was to determine whether Sirt5-mediated desuccinylation restores the metabolism protects brain against subarachnoid hemorrhage (SAH).Male C57BL/6 or Sirt5-/- mice were used. endovascular perforation SAH model applied. Protein lysine succinylation cortex examined using liquid chromatography-tandem mass spectrometry analysis. evaluated by measurement...
Three previously undescribed iridoid glycosides, 6α-O-trans-sinapoyl-paederosidic acid ethyl ester (1), 6'-O-trans-feruloyl-paederosidic methyl (2), and 10-O-trans-p-coumaroyl-(4S,6R)-3,4-dihydro-3β-ethoxypaederoside (3), were isolated from the 90% EtOH extract of aerial parts Paederia yunnanensis. The structures new compounds elucidated by spectral methods such as 1D 2D (1H-1H COSY, HMQC, HMBC) NMR spectrometry, HR-ESI-MS, well ECD data. tested in vitro for cytotoxic activity against five...
High-temperature (HT) stress has been recognized as one of the main factors restricting normal growth and development cotton severely affects fiber quality yield. To elucidate regulatory mechanism male sterility-related hormones in Gossypium barbadense under HT stress, we explored candidate genes closely related to sterility G. barbadense. We studied expression profiles anthers GB150 by combining transcriptomic metabolomic analyses. Through a combined analysis transcriptional metabolism...
The aim of this study was to perform molecular characterization for and determine the antimicrobial susceptibility profiles Clostridium difficile collected from hospitals during a 4-year period (2009-2013) in China.Strains toxigenic C. were isolated patients with diarrhoea, followed by typing using multilocus sequence (MLST) testing 10 antimicrobials E-test. mechanisms resistance moxifloxacin, erythromycin, clindamycin tetracycline investigated PCR.A total 405 non-duplicate isolates...
Purpose: To investigate the occurrence and genetic characteristics of bla IMP-26 -positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods: Species identification was determined by MALDI-TOF MS Sanger sequencing. Antimicrobial susceptibility testing performed agar dilution broth microdilution. Whole-genome sequencing conducted using Illumina HiSeq 4000-PE150 PacBio Sequel platforms, genome annotated RAST annotation server. The ANI analysis genomes...
The purpose of this study was to evaluate the risk factors, outcomes and epidemiology associated with Clostridium difficile infection (CDI) in patients haematological malignancies a tertiary care hospital China. C. screening performed on admitted for chemotherapy or haematopoietic stem cell transplantation between 2009 2013. isolates were analysed by multilocus sequence typing, retrospective chart review all positive toxin assay. CDI diagnosed 21 haematology-oncology ward 14 marrow service...
The increasing prevalence and transmission of the carbapenem resistance gene bla NDM-5 has led to a severe threat public health. So far, been widely detected in various species Enterobacterales different hosts across cities. However, there is no report on NDM-5- harboring Morganella morganii. In January 2016, first NDM-5-producing morganii L241 was found stool sample patient diagnosed as recurrence liver cancer China. Identification performed using 16S rRNA sequencing. Carbapenemase genes...