A5067708732- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Gut microbiota and health
- Glioma Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA Research and Splicing
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Economic and Financial Impacts of Cancer
- Antibiotics Pharmacokinetics and Efficacy
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Intracerebral and Subarachnoid Hemorrhage Research
Yangzhou University
2021-2025
Xijing Hospital
2019-2024
Air Force Medical University
2013-2024
Shanghai Jiao Tong University
2018-2022
Renji Hospital
2018-2022
Aerospace Center Hospital
2022
Ruijin Hospital
2021
Northeast Forestry University
2020
Soochow University
2017
Abstract Gut microbiota‐mediated colonization resistance (CR) is crucial in protecting the host from intestinal infections. Sleep deprivation (SD) an important contributor disturbances of homeostasis. However, whether and how SD affects CR remains largely unknown. Here, it shown that impairs mice, whereas nicotinamide mononucleotide (NMN) supplementation restores it. Microbial diversity metabolomic analyses suggest gut microbiota metabolite profiles SD‐treated mice are highly shaped, NMN...
Tigecycline is a last-resort antibiotic to treat complicated infections caused by multidrug-resistant pathogens, while the emergence of plasmid-mediated tet(X) family severely compromises its clinical efficacy. Novel antimicrobial strategies not limited new antibiotics in pharmaceutical pipeline are urgently needed. Herein, we reveal metabolic disparities between tet(X)-negative and -positive E. coli, including distinct energy demand patterns under tigecycline exposure. In particular,...
Antimicrobial resistance poses a severe threat to human health, with colistin serving as critical medication in clinical trials against multidrug-resistant Gram-negative bacteria. However, the efficacy of is increasingly compromised due rise MCR-positive bacteria worldwide. Here, we reveal notable metabolic disparity between mcr-positive and -negative through transcriptome metabolomics analysis. Specifically, pyridoxal 5'-phosphate (PLP), active form vitamin B6, was significantly diminished...
Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological molecular features are major obstacles to accurate predict survival evaluate efficacy of chemotherapy or radiotherapy. Reliable prognostic biomarkers urgently needed for postoperative GBM patients. The protein coding genes (PCGs) long non-coding RNA (lncRNA) gene expression profiles 233...
Abstract Circular RNA s (circ s) have been demonstrated to be involved in various biological processes. Nevertheless, the function of circ medulloblastoma ( MB ) is still unknown. The present study aimed investigate expression profiles and related mechanisms for regulating proliferation growth tumor cells . were screened from four normal cerebellum samples using a HiSeq Sequencer. Bioinformatic analysis was employed predict interaction between mRNA Subsequently, levels eight differential...
Circular RNAs (circRNAs) are widely expressed non-coding in eukaryotic cells, involved regulating tumorigenesis of several types cancers. However, the expression profiles and precise functional role glioblastoma remain unclear.Circ-EPB41L5 was downregulated tissues cell lines compared to normal brain lines. Low circ-EPB41L5 correlated poor prognosis patients, while overexpression inhibited proliferation, clone formation, migration, invasion abilities glioma suppression had counter effects....
Background: Lung cancer is the leading source of cancer-caused disability-adjusted life years. Medical cost burden impacts well-being patients through reducing income, cutting daily expenses, curtailing leisure activities, and depleting exhausting savings. The COmprehensive Score for Financial Toxicity (COST) was created validated by De Souza colleagues. Our study intends to measure financial burdens therapy investigate link between toxicity health-related quality (HRQoL) in an advanced lung...
Highlights•Moderate exercise enhances gut colonization resistance against MRSA in mice•D. newyorkensis (L8) is the key bacterium mediating increased resistance•Probiotic strain L8 thwarts by competing for carbon source fucoseSummaryGut microbiota plays a crucial role resisting invasion of pathogens, particularly multidrug-resistant (MDR) bacteria, which pose significant threat to public health. While offers numerous health benefits, its impact on host remains largely unclear. In this study,...
The emergence of antibiotic tolerance, characterized by the prolonged survival bacteria following exposure, in natural bacterial populations, especially pathogens carrying resistance genes, has been an increasing threat to public health. However, major causes contributing formation tolerance and underlying molecular mechanisms are yet poorly understood. Herein, we show that potassium sorbate (PS), a widely used food additive, triggers high level fluoroquinolone mobile colistin gene mcr....
Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated levels colon. Mechanistically, intestinal
ABSTRACT Antimicrobial resistance is rapidly increasing worldwide, highlighting the urgent need for pharmaceutical and nonpharmaceutical interventions to tackle different-to-treat bacterial infections. Tigecycline, a semi-synthesis glycylcycline parenteral administration, widely recognized as one of few effective therapies available against pan-drug resistant Gram-negative pathogens. Regrettably, efficacy multiple drugs, including tigecycline, currently being undermined due emergence...
Background: Primary lymphoma of bone (PLB) is an extremely rare malignancy arising in the skeletal system. There no consensus over best definition PLB. Most published articles are single-institutional retrospective studies with a limited sample size. The rarity PLB and discrepancies on diagnostic criteria has resulted vague understanding Methods We retrospectively analyzed clinical characteristics prognostic factors 2558 patients who were registered Surveillance, Epidemiology, End Results...
Abstract Background The crosstalk between the ubiquitin‐proteasome and immune system plays an important role in health pathogenesis of viral infection. However, there have been few studies ubiquitin activation severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Methods We investigated effect ubiquitination on SARS‐CoV‐2 infection patient prognosis by integrating published disease 2019 (COVID‐19) multi‐transcriptome data bioinformatics methods. Results differential expression...
OBJECTIVE: To investigate the expression pattern, prognostic value and biological functional of LINC00174 in glioma. METHODS: In total, 140 glioma samples were collected as discovery cohort. TCGA RNA sequence dataset was obtained validation set. Kaplan–Meier survival multivariate Cox analysi s performed to evaluate difference. Furthermore, function analyzed by clonogenic intracranial tumor model assays. RESULTS: Overexpressed significantly correlated with grade well higher mortality analysis...
Recently, a novel efflux pump gene cluster called tmexCD1-toprJ1 and its variants have been identified, which undermine the antibacterial activity of tigecycline, one last remaining options effective against multidrug-resistant (MDR) Gram-negative bacteria. Herein, we report potent synergistic effect non-steroidal anti-inflammatory drug benzydamine in combination with tigecycline at sub-inhibitory concentrations various temxCD-toprJ-positive pathogens. The killed all drug-resistant pathogens...
The study aimed to determine the prevalence and pathogens of invasive fungal infection (IFI) among intensive care unit (ICU) patients. next goal was investigate association between empirical antifungal treatment mortality in ICU patients.Using microbiological events, we identified all patients with IFI then retrieved electronic clinical data from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. were statistically analyzed using t-tests, chi-square tests, log-rank Cox...
Leukoaraiosis (LA) results from ischemic injury in small cerebral vessels, which may be attributable to decreased vascular density, reduced cerebrovascular angiogenesis, blood flow, or microcirculatory dysfunction the brain. In this study, we enrolled 357 patients with mild intracerebral hemorrhage (ICH) five hospitals China and analyzed relationships between LA clinical symptom severity at admission, neurological function prognosis 3 months, 1-year stroke recurrence. Patients were divided...