A5007558664- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Metabolism, Diabetes, and Cancer
- Heat shock proteins research
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Inorganic Fluorides and Related Compounds
- Luminescence Properties of Advanced Materials
- Cancer-related gene regulation
- Nutrition and Health in Aging
- Gastrointestinal Tumor Research and Treatment
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Chronic Lymphocytic Leukemia Research
Xijing Hospital
2019-2025
Wenzhou Medical University
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
Shanghai East Hospital
2015-2024
Air Force Medical University
2019-2022
Beijing University of Chemical Technology
2020-2021
China Agricultural University
2020
Anhui Provincial Hospital
2020
Tongji University
2015
Tongji Hospital
2015
Pulmonary fibrosis is a chronic, progressive lung disease associated with damage and scarring. The pathological mechanism causing pulmonary remains unknown. Emerging evidence suggests prominent roles of epithelial-mesenchymal transition (EMT) alveolar epithelial cells (AECs) in myofibroblast formation fibrosis. Our previous work has demonstrated the regulation YY1 idiopathic pathogenesis fibroid lung. However, specific function AECs during yet to be determined. Herein, we found higher level...
Pancreatic ductal adenocarcinoma (PDAC) is one of most lethal cancers and projected to be the second leading cause cancer deaths in United States by 2030. The lack effective treatment increased incidence PDAC encourage a deeper knowledge progression. By analyzing long noncoding RNA (lncRNA) dataset, we found that LINC00941 expression led poor outcomes patients. Furthermore, vitro vivo experiments revealed promoted cell growth enhancing aerobic glycolysis. Mechanistically, was interact with...
Ribosomal S6 protein kinase 4 (RSK4), a member of the serine‒threonine family, plays vital role in Ras‒MAPK pathway. This is responsible for managing several cellular activities, including cell growth, proliferation, survival, and mobility. In this study, we observed higher RSK4 expression clear renal carcinoma (ccRCC) than normal kidney tissue, overexpression might predict poor outcomes ccRCC patients. Notably, (RCC) rich blood vessels; therefore, study aimed to explore biological function...
Melatonin, which is synthesized by the pineal gland and released into blood, exhibits antitumor properties. However, mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In present study, effect of melatonin on nuclear factor (NF)-κB signaling pathway mitogen-activated protein kinase pathway, involving p38 c-Jun-N-terminal (JNK), were investigated SGC7901 gastric cancer cells. addition, survival, migration apoptosis cells was vitro order to evaluate use for...
Abstract Background To investigate the expression and function of RSK4, MMP-9 CD44 in primary clear cell renal carcinoma (primary ccRCC) metastatic (metastatic ccRCC), as well correlation with clinicopathological features patients. Method The levels 52 ccRCC samples 48 were detected by immunohistochemistry, relationship between prognosis patients was statistically analysed. Ectopic RSK4 lines performed to determine its effect on cycle regulation, tumour invasiveness, capability. Results...
Colorectal cancer (CRC) is the third most frequently diagnosed worldwide. As a high-risk factor for CRC, ulcerative colitis (UC) has been demonstrated to lead epithelial dysplasia, DNA damage, and eventually cancer. There are approximately 18% of patients with UC may develop CRC.The gene expression profiles were retrieved from Gene Expression Omnibus. The Database Annotation, Visualization Integrated Discovery was employed conduct annotations. Protein-protein interaction network constructed...
Abstract TRIM22 is involved in tumorigenesis and development, but its mechanism not clear. In this study, we investigated the expression biological role of gastric cancer. We found that mRNA protein was abnormally low cancer tissues cells correlated with tumor size depth invasion. Overexpression significantly inhibited proliferation, colony formation, migration downregulated HSPA6. However, HSPA6-siRNA complementation test showed did regulate cell proliferation through Furthermore,...
Primary gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) is the most common lymphoma, but its genetic features are poorly understood. We performed whole-exome sequencing of 25 primary tumor samples from patients with GI-DLBCL and 23 matched normal tissue samples. Oncogenic mutations were screened, correlations between clinicopathological characteristics analyzed. Twenty-five enrolled in mutation analysis a median 184 (range 79–382) protein-altering variants per patient. identified...
Aims: To explore the feasibility of sleeve gastrectomy (SG) as a treatment for polycystic ovary syndrome (PCOS) and its potential to improve clinical efficacy in PCOS patients with symptoms oligomenorrhea. Patients Methods: Twenty-four obese underwent laparoscopic SG. Simultaneously, 24 received lifestyle modification therapy (LMT). Follow-ups were conducted at 3–6 months. Weight loss, menstruation, improvements hirsutism metabolic compared. Results: In SG group, 20 restored normal menstrual...
The amino acid transporter SLC6A14, which transports 18 of the 20 proteinogenic acids, is too low to be detected in healthy normal tissues but significantly increased some solid cancers. However, little known about roles SLC6A14 colorectal cancer (CRC).The mRNA and protein levels were using TCGA database, real-time polymerase chain reaction, western blot, tissue microarrays, respectively. Amino acids concentration was determined by LC-MS/MS. Cell proliferation apoptosis MTT assay flow...
The aim of this study was to investigate and interpret the expression level potential function TCEA3 in gastric cancer.qRT-PCR used determine cancer tissues. Pearson χ2 test performed clarify correlation between patients' clinicopathologic characteristics. Biological tested by proliferation assay colony formation assay. Flow cytometry apoptosis induction.TCEA3 significantly downregulated tissues compared with paired normal Poor prognoses were observed low group patients contrast high group....
Laparoscopic anterior resection with natural orifice specimen extraction (NOSE) avoids extra abdominal incision during colorectal surgery. Some surgeons realized the benefits of NOSE on clinical efficacy. We compared efficacy laparoscopic NOSE, non-NOSE and open surgery (OS) for short-term recovery quality life (QoL).A single randomized controlled trial middle upper rectal cancer between April 2014 February 2018. Preoperative postoperative variables were analyzed groups. 6 months QoL was...
Colorectal cancer (CRC) is a significant health issue worldwide. Recent studies highlight the critical role of miRNAs in CRC development, particularly miR-137, which acts as key tumor suppressor. Despite its known role, further exploration miR-137's downstream signaling needed to understand biology and therapeutic potential. We examined methylation status miR-137 using one TCGA data three GEO sets. A clinical validation cohort 78 samples was analyzed MSP for promoter methylation. Various...
Emerging evidence suggests that hypermethylation of HOXD10 plays an important role in human cancers. However, the biological and clinical impacts overmethylation its downstream targets colorectal cancer remain unknown. We evaluated methylation level paired normal tissues (n = 42) by using pyrosequencing, followed validation status from The Cancer Genome Atlas (TCGA) datasets with 302 38 tissues. function was characterized cell lines. further effects on chemoresistance our established...
Abstract Extracellular vesicles (EVs) play important roles in many pathophysiologies as cell‐to‐cell communication vehicles. However, the features and potential functions of EVs haemorrhoids remain unclear. Therefore, we performed microRNA (miRNA) microarray analysis derived from haemorrhoid tissue to identify profile miRNAs these predict their functions. We obtained typical both control tissues. Microarray identified 447 with significant differential expresssion (DE): 245 upregulated 202...
Purpose: Colorectal cancer (CRC) is one of the most common types malignancies, and radiochemotherapy (RCT) followed by surgery recommended approach for CRC treatment. However, some cases do not respond to first-line conventional chemotherapy or even progress further after Moreover, there a risk severe side effects, such as radiodermatitis. Therefore, identifying predictors RCT sensitivity an essential step toward predicting eventually overcoming resistance. Materials Methods: We used...