A5060958502- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Veterinary medicine and infectious diseases
- Protist diversity and phylogeny
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Retinal Development and Disorders
- Renal and related cancers
- Chromosomal and Genetic Variations
- Autophagy in Disease and Therapy
- Genomics and Chromatin Dynamics
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Hedgehog Signaling Pathway Studies
- HIV Research and Treatment
- Genetic Syndromes and Imprinting
Shandong Normal University
2016-2025
State Key Laboratory of Medicinal Chemical Biology
2016-2025
Nankai University
2016-2025
Shanghai Sixth People's Hospital
2008-2024
Shanghai Jiao Tong University
2010-2024
Third Affiliated Hospital of Zhengzhou University
2024
Pfizer (United States)
2024
Hubei University of Medicine
2021-2024
Taihe Hospital
2021-2024
Ningbo University
2023
Owing to high antibiotic resistance and thermotolerance, bacterial biofilm infections (BBIs) are refractory elimination. Iron is essential for growth metabolism, bacteria can thus accumulate iron from surrounding cells maintain formation survival. Consequently, deficiency in the microenvironment (BME) leads functional failure of innate immune cells. Herein, a novel antibiofilm strategy iron-actuated Janus ion therapy (IJIT) proposed regulate metabolism both A BME-responsive photothermal...
Patients with inflammatory bowel diseases (IBD) harbour intestinal bacterial communities altered composition compared healthy counterparts; however, it is unknown whether changes in the microbiota are associated genetic susceptibility of individuals for developing disease or instead reflect other environment related to itself. Since deficiencies innate immune receptors Nod1 and Nod2 linked IBD, we tested hypothesis that Nod-signaling alters profiles subsequently community structure. We used...
Epithelial-mesenchymal transition (EMT) is critically involved in a variety of biological processes. Electrochemical sensing offers potential to develop more effective technology for EMT detection. In this study, by using the unique performance quantum dot (QD)-nanocomposite materials, we establish an electrochemical biosensor that can specifically detect change E-cadherin and analyze different stages EMT. The signal largely magnified due transmission molecular information electronic device....
The complicated hyperglycaemic and chronic inflammation of diabetic wounds in orthopaedic surgery leads to dysregulated immune cell function potential infection risk. Immune interventions face a possible contradiction between simultaneous establishment the pro-inflammatory microenvironment response bacterial invasion anti-inflammatory required for tissue repair. To study this accelerate diabetic-wound healing, we developed photocurable methacryloxylated silk fibroin hydrogel (Sil-MA) system,...
Abstract Biofilm‐infected diabetic wounds (BIDWs) with hyperglycemia and bacterial colonization are characterized by disordered inflammation abnormal activation of NLRP3 inflammasome, leading to sustained macrophage M1 polarization neutrophil extracellular traps (NETs) formation. An immoderate anti‐inflammatory treatment that downregulates in turn promotes the persistence biofilm infections impairs healing BIDWs. Therefore, reconciling elimination immune regulation holds promise curing...
Implant-related infections (IRIs) are catastrophic complications after orthopedic surgery. Excess reactive oxygen species (ROS) accumulated in IRIs create a redox-imbalanced microenvironment around the implant, which severely limits curing of by inducing biofilm formation and immune disorders. However, current therapeutic strategies commonly eliminate infection utilizing explosive generation ROS, exacerbates redox imbalance, aggravating disorders promoting chronicity. Herein,...
Soft tissue injuries (STIs) are the most common cause of extremity pain and motion dysfunction. Persistent inflammatory activation immune cells characterized by senescence‐associated secretory phenotype (SASP) mitochondrial stress considered primary causes STIs, a pathological process also termed inflammaging. Meanwhile, scavenging excessive “cellular waste” in inflammaging microenvironment further activating repair processes remain elusive. Herein, an anti‐inflammaging photothermal hydrogel...
Abstract The photoreceptor cilium is vital for maintaining the structure and function of retina. However, molecular mechanisms underlying integrity retinal homeostasis are largely unknown. Herein, it shown that kinesin family member 11 (KIF11) localizes at transition zone (connecting cilium) plays a crucial role in orchestrating integrity. KIF11 depletion causes malformations both ciliary axoneme membranous discs, resulting degeneration accumulation drusen‐like deposits throughout...
The aim of this study was to evaluate the therapeutic effects Bletilla striata polysaccharide (BSP) on wound healing in diabetes mellitus (DM) and explore underlying mechanisms. DM mouse models were induced by high fat-diet feeding combined with low-dose streptozocin injection. To establish diabetic foot ulcer (DFU) models, mice wounded dorsal surface. Subsequently, treated vehicle or BSP for 12 days monitored. production interleukin-1β (IL-1β), tumor necrosis factor-α, macrophages...
The synaptonemal complex (SC) is an ordered but highly dynamic structure assembled between homologous chromosomes to control interhomologous crossover formation, ensuring accurate meiotic chromosome segregation. However, the mechanisms regulating SC assembly and dynamics remain unclear. Here, we identified two new components, SYP-5 SYP-6, in Caenorhabditis elegans that have distinct expression patterns form units with other SYPs through stable interactions. SYP-6 exhibit diverse vivo...
Multicilia are delicate motile machineries, and how they accurately assembled is poorly understood. Here, we show that fibrogranular materials (FGMs), large arrays of electron-dense granules specific to multiciliated cells, essential for their ultrastructural fidelity. Pcm1 forms the granular units further network into widespread FGMs, which abundant in spherical FGM cores. cores selectively concentrate multiple important centriole-related proteins as clients, including Cep131 specifically...
Shanghai, in east China, has one of the world's highest burdens Helicobacter pylori infection. While multidrug regimens can effectively eradicate H. pylori, increasing prevalence antibiotic resistance (AR) been recognized by WHO as 'high priority' for urgent need new therapies. Moreover, genetic characteristics AR Shanghai is under-reported. The purpose this study was to determine prevalence, re-substantiate resistance-conferring mutations, and investigate novel elements associated with AR.
Retinopathy of prematurity (ROP) is one the leading causes childhood visual impairment and blindness. However, there are still very few effective pharmacological interventions for ROP. Histone deacetylase 6 (HDAC6)-mediated disassembly photoreceptor cilia has recently been implicated as an early event in pathogenesis Herein it shown that enhanced expression HDAC6 by intravitreal injection adenoviruses encoding induces typical pathological changes associated with ROP mice, including...
Bacillus cereus is a Gram-positive bacterium that mainly causes self-limiting emetic or diarrheal illness but can also cause skin infections and bacteremia. Symptoms of B. ingestion depend on the production various toxins target gastric intestinal epithelia. From screen bacterial isolates from human stool samples compromised barrier function in mice, we identified strain disrupted tight adherens junctions epithelium. This activity was mediated by pore-forming exotoxin alveolysin, which...