A5001761395- Gut microbiota and health
- Tryptophan and brain disorders
- Microplastics and Plastic Pollution
- Recycling and Waste Management Techniques
- Air Quality and Health Impacts
- Clostridium difficile and Clostridium perfringens research
- Climate Change and Health Impacts
- Healthcare and Environmental Waste Management
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Probiotics and Fermented Foods
- Obsessive-Compulsive Spectrum Disorders
- Transcranial Magnetic Stimulation Studies
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Functional Brain Connectivity Studies
- Effects and risks of endocrine disrupting chemicals
- Hearing, Cochlea, Tinnitus, Genetics
- Social Acceptance of Renewable Energy
- Tannin, Tannase and Anticancer Activities
- COVID-19 epidemiological studies
- Neurological Disorders and Treatments
- RNA modifications and cancer
Chinese Research Academy of Environmental Sciences
2020-2025
Jinan University
2024-2025
Peking University
2015-2023
Southeast University
2022
The environmental persistence of antiviral drugs poses serious safety hazards to aquatic ecosystems through their selective pressure on microorganisms, yet the understanding drugs’ impact microbial community structures remains limited. In this study, surface water samples from Beijing were analyzed for drug concentrations using UPLC-MS/MS, and abundance was assessed via 16S amplicon sequencing. Employing these methods, we investigated mechanisms which may exert ecological risks communities....
Drinking water is one of the primary sources microplastic exposure in humans. However, extent to which microplastics drinking contribute overall human health remains unclear. The aim this work assess characteristics contamination bottled and tap water, explore explain geographical distribution selected studies, evaluate microplastics, suggest areas for future research. Based on latest literature from 2018 2023 (n = 66), we quantified constituent profiles explored their global heterogeneity....
Preclinical studies have shown that the gut microbiota can play a role in schizophrenia (SCH) pathogenesis via gut-brain axis. However, its antipsychotic treatment response is unclear. Here, we present 24-week follow-up study to identify microbial biomarkers for SCH diagnosis and response, using sample of 107 first-episode, drug-naïve patients, healthy controls (HCs). We collected biological samples at baseline (all participants) time points after risperidone (SCH patients). Treatment was...
Microplastic pollution is now ubiquitous in the environment, making human exposure to microplastics unavoidable. This results detection of bodies, including blood. However, pathways through which enter bloodstream still need be clarified, despite studies several direct and indirect routes. Herein, potential occurrence infusion therapy sets, glass bottles, plastic bags, tubes, was investigated. The showed that a total eight microplastics, ranging from 4 148 μm size, were identified three...
Abstract Background and Hypothesis Schizophrenia (SCZ) is associated with complex crosstalk between the gut microbiota host metabolism, but underlying mechanism remains elusive. Investigating aberrant neurotransmitter processes reflected by alterations identified using multiomics analysis valuable to fully explain pathogenesis of SCZ. Study Design We conducted an integrative data, including serum metabolome, fecal metagenome, single nucleotide polymorphism neuroimaging data obtained from a...
Chemically synthesized DNA fragments are increasingly recognized as highly valuable tracers for investigating environmental pollution due to their inherent high specificity, sequence diversity, friendliness, stable migration, and detection sensitivity, outperforming traditional ion dye tracers. Despite advantages, a systematic approach generating suitable sequences, which is critical requirement preparing tracers, remains not fully developed. This study introduces an optimization generator...
To explore the clinical characteristics of noise-induced hearing loss (NIHL) caused by long-term exposure to steady-state noise and find a possible inflection point time leading deterioration. Subjects exposed were selected as noise-exposed group matched with control individuals not noise. Both groups underwent pure-tone audiometry (PTA) distortion product otoacoustic emissions (DPOAE), their conditions analyzed. The most significant disparities in NIHL between early late was evaluated....
Federated learning is a powerful tool for securing participants’ private data due to its ability make “available but not visible”. In recent years, federated has been enhanced by the emergence of multi-weight aggregation protocols, which minimize impact erroneous parameters, and verifiable prevent server misbehavior. However, it still faces significant security performance challenges. Malicious participants may infer others or carry out poisoning attacks compromise model’s correctness....
Background and objectives Disease severity prognosis of coronavirus disease 2019 (COVID-19) with other viral infections can be affected by the oropharyngeal microbiome. However, limited research had been carried out to uncover how these diseases are differentially microbiome patient. Here, we aimed explore characteristics microbiota COVID-19 patients compare them those similar symptoms. Methods was diagnosed in through detection severe acute respiratory syndrome 2 (SARS-CoV-2) quantitative...
The relationship between oral and gut microbiota in alcohol dependence (AD) is not well understood, particularly the effects of on intestinal microbiota. current study aimed to explore association AD clarify whether could ectopically colonize into gut.16S rRNA sequence libraries were used compare microbial profiles persons with healthy controls (HC). Source Tracker NetShift identify bacteria responsible for ectopic colonization indicate driver function bacteria.The α-diversity was...
Microplastic pollution is not only an environmental problem but also a social problem. Many studies have been conducted on the sources, abundance, and distribution of microplastics in environment, understanding human exposure levels potential health risks remains very limited. Based bibliometric methods, present review systematically summarized pathways humans, then characteristics adverse impacts were expounded upon. Available literature showed that bodies mainly concentrated sizes smaller...
Background and objectives The oral gut microbiota play significant roles in childhood asthma pathogenesis. However, the communication dynamics pathogenic mechanisms by which influence disease development remain incompletely understood. This study investigated potential oral-originated microbiota, specifically Prevotella genus, may contribute to etiology. Methods Oral swab fecal samples from 30 asthmatic children healthy controls were collected. Microbiome composition was characterized using...
Abstract Mutants in the basal core promoter (BCP) and precore (PC) regions of hepatitis B virus (HBV) genome are associated with progression chronic (CHB) infection. However, quasispecies characteristics naturally occurring mutants those HBeAg-positive CHB patients has not been well described, partly limited by quantitative assay. This study aimed to develop an Ion Torrent deep sequencing assay determine BCP PC mutant percentages who were treatment naïve correlate them different viral host...
Sepsis-induced disseminated intravascular coagulation (DIC) is a common life-threatening terminal-stage disease with high mortality. This study aimed to identify effective miRNAs as therapeutic targets for DIC. Bioinformatics and luciferase reporter gene analyses were performed predict miR-19a-3p validate that it tissue factor (TF). Quantitative real-time PCR was used detect the expression of TF, TF procoagulant activity determined using chromogenic substrate method. Western blotting protein...
Aquatic plants are fundamental for aquatic ecosystems. Understanding variations in geographic patterns of plant diversity across growth forms is important conservation and restoration Environmental drivers, including climate, climate heterogeneity, water chemistry, habitat availability geodiversity, could influence species composition communities, yet their relative impacts remain controversial. Here, we examined drivers richness Chinese with different forms. We compiled distributions 656...