A5048474193- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Anesthesia and Neurotoxicity Research
- Climate Change and Health Impacts
- Heavy Metal Exposure and Toxicity
- Chromium effects and bioremediation
- Metabolomics and Mass Spectrometry Studies
- Advanced Nanomaterials in Catalysis
- Occupational and environmental lung diseases
- Cancer-related molecular mechanisms research
- Carcinogens and Genotoxicity Assessment
- Dye analysis and toxicity
- Healthcare and Environmental Waste Management
- Microplastics and Plastic Pollution
- Curcumin's Biomedical Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hydrogen's biological and therapeutic effects
- Gut microbiota and health
- Effects and risks of endocrine disrupting chemicals
- Occupational exposure and asthma
- RNA modifications and cancer
- Child Nutrition and Water Access
- Medicinal Plants and Neuroprotection
- Energy and Environment Impacts
- Iron Metabolism and Disorders
Peking University
2016-2025
Chinese Academy of Surveying and Mapping
2019-2022
State Council of the People's Republic of China
2021
Zhejiang University of Technology
2005-2008
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) have potential applications as food additives, but concerns persist about their safety. Children are identified having the highest exposure and may face greatest health risks. However, toxicological sensitivity of TiO NPs in different ages is not clear. Here, a comparative toxicity study 3‐week (youth) 8‐week (adult) old Sprague‐Dawley rats reported following oral at doses 0, 10, 50, 200 mg kg −1 body weight per day for 30 days. The organ...
The present study explored the role of gut microbiota and gut-associated metabolism in oral toxicity induced by TiO<sub>2</sub> NPs.
Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO2 NPs) have been increasingly exposed the environment public. However, health effects of oral exposure TiO2 NPs are still controversial. This study aimed illustrate hepatotoxicity induced by underlying mechanisms. Rats were administered with (29 nm) orally at doses 0, 2, 10, 50 mg/kg daily for 90 days. Changes gut microbiota hepatic metabolomics analyzed explore role...
Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO2) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is explore effects among workers who were exposed nano-TiO2 and identify biomarkers associated with exposure. A cross-sectional was conducted in a manufacturing plant eastern China. Exposure assessment characterization TiO2 particles performed packaging...
The main goal of this study was to use the synthetic minority oversampling technique (SMOTE) expand quantity landslide samples for machine learning methods (i.e., support vector (SVM), logistic regression (LR), artificial neural network (ANN), and random forest (RF)) produce high-quality susceptibility maps Lishui City in Zhejiang Province, China. Landslide-related factors were extracted from topographic maps, geological satellite images. Twelve selected as independent variables using...
The present study investigated the effect of oral exposure to TiO<sub>2</sub> NPs on lipid metabolism by serum lipidomics.
Existing literature pointed out that the liver may be target organ of toxicity induced by titanium dioxide nanoparticles (TiO2 NPs) via oral exposure. Gender differences in health effects widely exist and relevant toxicological research is important for safety assessment. To explore gender susceptibility TiO2 NP-induced hepatic underlying mechanism, we examined female male Sprague-Dawley rats administrated with NPs orally at doses 0, 2, 10 50 mg/kg body weight per day 90 days. The serum...
A growing body of evidence suggests that non-optimal ambient temperatures are associated with increased incidence rate and mortality thromboembolic diseases. We aim to investigate the association between apparent temperature (AT) coagulation, which is a central pathological link in formation thrombi. In this study, we conducted time series analysis using data from 18,894 participants collected health check-up center Beijing 2014 2023, validated our findings 20,549 an andrology outpatient...
(1) Background: Silica nanoparticles (SiO2 NPs) have a high potential for human exposure and tend to accumulate in the liver. This study aimed explore size-dependent cytotoxicity induced by SiO2 NPs identify key molecular pathways at vitro level through proteomics, metabolomics, combination of multiple omics methods. (2) Methods: The hepatoma cells (HepG2) were exposed three different sizes (60, 250, 400 nm) doses 0, 12.5, 25, 50, 100, 200 μg/mL 24 h. (3) Results: Exposure 60 nm more...
Air pollution has been widely recognized as a risk factor for neurological disorders, and the gut microbiome may play mediating role. However, current evidence remains limited. In this study, mouse model was employed with continuous exposure to real-time air from conception late adolescence. Effects of growth-stage on microbiome, host metabolites, brain tissue were assessed. Pathological damage in hippocampus cortex observed. Fecal metagenomic sequencing revealed alterations both...
Abstract As food additives, titanium dioxide nanoparticles (TiO 2 NPs) have been widely used in various products that are usually simultaneously consumed with a high content of sugar, thus necessitating research on the effect TiO NPs glucose homeostasis. We conducted an animal study to explore orally administrated absorption and metabolism rats at 0, 2, 10 50 mg kg –1 body weight day for 30 90 days. The results showed oral exposure caused slight temporary hypoglycemic days post‐exposure but...