A5101780698- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Cancer, Lipids, and Metabolism
- Noise Effects and Management
- Curcumin's Biomedical Applications
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Indoor Air Quality and Microbial Exposure
- Prostate Cancer Treatment and Research
- Natural product bioactivities and synthesis
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Chromium effects and bioremediation
- Cancer Immunotherapy and Biomarkers
- Free Radicals and Antioxidants
- Heavy Metal Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Energy and Environment Impacts
- CAR-T cell therapy research
Peking University
2012-2025
Gansu Agricultural University
2024
Duke University
2016-2023
Heat Biologics (United States)
2021
Duke Institute for Health Innovation
2020
Durham Technical Community College
2020
Rutgers, The State University of New Jersey
1999-2015
In-Q-Tel
2012
Cancer Institute of Florida
2010
Rutgers Cancer Institute of New Jersey
2010
Oxidative stress is involved in thoracic diseases and health responses to air pollution. Malondialdehyde (MDA) a well-established marker of oxidative stress, but it may be present unconjugated conjugated forms. To our knowledge, no studies have conducted systemic evaluation both free MDA (unconjugated MDA) total (the sum across various types human biospecimens.Free were simultaneously measured range biospecimens, including nasal fluid (N=158), saliva exhaled breath condensate (N=40), serum...
Purpose: Nurses are undertaking considerable emotional and physical work, which may lead to unrecoverable fatigue. This study aimed evaluate the level of chronic fatigue explore its associated factors among Chinese nurses in hope providing scientific evidence for fatigue-reduction strategies. Methods: cross-sectional was carried out Liaoning Province, China 2018. The recruited 700 collected 566 effective respondents. Chronic fatigue, demographic factors, job conditions, intelligence were...
<h3>Importance</h3> Fine particles (particulate matter 2.5 μm [PM<sub>2.5</sub>]), a ubiquitous air pollutant, can deposit in the small airways that play vital role asthma. It appears to be unknown whether use of PM<sub>2.5</sub>filtration device improve airway physiology and respiratory inflammation children with <h3>Objective</h3> To discover what pathophysiological changes are associated using PM<sub>2.5</sub>-removing bedrooms <h3>Design, Setting, Participants</h3> Children mild or...
Fine particulate matter (PM2.5) with a higher oxidative potential has been thought to be more detrimental pulmonary health. We aim investigate the associations between personal exposure PM2.5 and outcomes in asthmatic children. measured each of 43 children 4 times for airway mechanics, lung function, inflammation, asthma symptom scores. Coupling indoor outdoor concentrations mass, constituents, individual time-activity data, we calculated 24 h average exposures 0-3 days prior health outcome...
Abstract Epidemiology studies suggest that statins and nonsteroidal anti-inflammatory drugs reduce the risk of prostate cancer. In present study, LNCaP cells were cultured in regular medium containing fetal bovine serum or supplemented with charcoal-stripped to mimic androgen deprivation treatment. We found atorvastatin (Lipitor) celecoxib (Celebrex) treatment androgen-depleted inhibited growth stimulated apoptosis. A combination was more effective than either agent alone. animal studies,...
Portable air cleaners are increasingly used in polluted areas an attempt to reduce human exposure; however, there has been limited work characterizing their effectiveness at reducing exposure. With this mind, we recruited forty-three children with asthma from suburban Shanghai and deployed (with HEPA activated carbon filters) bedrooms. During both 2-week filtration non-filtration periods, low-cost PM2.5 O3 monitors were measure pollutants indoors, outdoors, for personal Indoor concentrations...
To investigate the effects and mechanisms of atorvastatin celecoxib administered individually or in combination on human prostate cancer PC-3 cells cultured vitro grown as xenograft tumors immunodeficient mice.Human culture were treated with alone combination. Severe combined (SCID) mice injected s.c. cells. The received daily i.p injections starting 2 days before tumor cell inoculation continuing during course treatment (10 microg/g body weight/d), microg/g/d), a microg/g/d) (5...
Existing studies on the inhalation toxicology of titanium dioxide (TiO2) have focused possible carcinogenic capacity; however researches cardiovascular effect are limited, particularly in terms susceptible animal models. The present study examined nano-TiO2 ApoE knockout mice (ApoE-/- mice), an atherosclerosis model. particles used were anatase type and diameter ranged from 5 to 10 nm. ApoE-/- randomly divided into five groups (high dose group, median low PBS vehicle control group...
The importance of airway mechanics has been increasingly recognized in pediatric asthma. However, no studies have examined responses to air pollution exposure asthmatic children.In this panel study involving indoor filtration manipulation that created a large gradient personal PM2.5, the and lung function 43 children 5-13 years old suburb Shanghai were measured four times within 3 consecutive months. Concentrations outdoor PM2.5 ozone coupled with individual time-activity data calculate...
Fine particulate matter (PM2.5) and ozone (O3) may exert oxidative damage in the nose, which is hypothesized to be associated with worsened asthma symptoms. This study, hence, explore whether an stress biomarker, malondialdehyde (MDA) nasal fluid, has potential aid personalized control. In a panel study of 43 asthmatic children, 5–13 years old, each child was measured 4 times 2-week interval between consecutive clinic visits. At visit, fluid urine samples were collected, fractional exhaled...
The androgen receptor (AR) has a critical role in prostate cancer development and progression. Several curcumin analogues (A10, B10, C10, E10 F10) with different linker groups were investigated for their effects human CWR‑22Rv1 LNCaP cell lines. ability of these compounds to inhibit testosterone (TT)‑ or dihydrotestosterone (DHT)‑induced AR activity was determined by an AR‑linked luciferase assay TT‑ DHT‑induced expression specific antigen. Compounds F10 had stronger inhibitory on the growth...
One hundred chromate production workers chronically exposed to low-level of hexavalent chromium [Cr(vi)] and eighty healthy individuals free from Cr exposure were recruited the study. Personal sampling airborne was conducted content quantified by Flame Atomic Absorption Spectrometry (FAAS). At end shift, blood samples collected element concentrations measured inductively coupled plasma mass spectrometry (ICP-MS) for Cr, Cd, Cu, Mo Se atomic emission (ICP-AES) Ca, Fe, Mg Zn. According our...
Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority pancreatic cancer patients, an approach to inhibit the progression growth using simultaneous administration agents that function both targets, should be considered. In present study, we assessed effects atorvastatin (Lipitor), celecoxib (Celebrex) tipifarnib (Zarnestra) on human cancer. in vitro studies, found treatment tumor cells with a combination atorvastatin, had stronger inhibitory effect...