A5100606421- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical and Biological Ozone Research
- Climate Change and Health Impacts
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Air Quality Monitoring and Forecasting
- Remote Sensing and Land Use
- RNA Interference and Gene Delivery
- Selenium in Biological Systems
- Occupational and environmental lung diseases
- Hydrogen's biological and therapeutic effects
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Natural Compounds in Disease Treatment
- Connexins and lens biology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell death mechanisms and regulation
- Noise Effects and Management
- Corporate Finance and Governance
- Neonatal Respiratory Health Research
- Heme Oxygenase-1 and Carbon Monoxide
- Biochemical effects in animals
- Nerve injury and regeneration
First Affiliated Hospital of Zhengzhou University
2023-2025
Wenzhou Medical University
2025
Weifang People's Hospital
2023-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Shanghai Chest Hospital
2002-2024
Shanghai Jiao Tong University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
National University Cancer Institute, Singapore
2015-2024
University of Oklahoma Health Sciences Center
2011-2024
Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood.
Abstract Constitutive activation of proinflammatory transcription factors such as STAT3 and NF-κB plays a pivotal role in the proliferation survival squamous cell carcinoma head neck (HNSCC). Thus, agents that can modulate deregulated have great potential both for prevention treatment HNSCC. In present report, we investigated effects garcinol, an active component Garcinia indica on various inflammatory mediators involved HNSCC progression using lines xenograft mouse model. We found garcinol...
BACKGROUND AND PURPOSE Constitutive activation of the signal transducer and activator transcription 3 (STAT3) pathway is frequently encountered in several human cancers including multiple myeloma (MM). Thus, agents that suppress STAT3 phosphorylation have a potential for treatment MM. In present report, we investigated whether thymoquinone (TQ), main component isolated from medicinal plant Nigella sativa , modulated signalling MM cells. EXPERIMENTAL APPROACH The effect TQ on both...
Activation of pro-inflammatory transcription factors NF-κB and signal transducer activator 3 (STAT3) is one the major contributors to both pathogenesis chemoresistance in multiple myeloma (MM), which results high mortality rate. Thus, present study, we investigated whether celastrol could suppress proliferation induce chemosensitization MM cells by interfering with STAT3 activation pathways.The effects were using a virtual predictive tumour cell system different lines resistant doxorubicin,...
Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential molecular therapeutic target in treatment various cancers. Herein, we report the synthesis trisubstituted-imidazoles identified 2-chloro-3-(4, 5-diphenyl-1H-imidazol-2-yl) pyridine (CIP) as lead cytotoxic agent. Naïve Base classifier model silico prediction revealed that CIP targets RAC-beta serine/threonine-protein kinase which comprises Akt. Furthermore, downregulated phosphorylation Akt, PDK mTOR proteins...
Particle size and surface chemistry are potential determinants of silver nanoparticle (AgNP) respiratory toxicity that may also depend on the lung inflammatory state. We compared effects intratracheally-administered AgNPs (20nm 110nm; polyvinylpyrrolidone (PVP) citrate-capped; 0.1 mg/Kg) in Brown-Norway (BN) Sprague-Dawley (SD) rats. In BN rats, there was both a neutrophilic eosinophilic response, while SD response at day 1, greatest for 20nm citrate-capped AgNPs. Eosinophilic cationic...
Mitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) other stimuli. We examined importance mtROS NLRP3 their interactions multiple ozone-induced lung inflammation emphysema.C57/BL6 mice were exposed ozone (2.5 ppm, 3 h) or filtered air twice a week over 6 weeks. MitoTEMPO (20 mg/kg), inhibitor mtROS, VX765 (100 caspase-1 activity, administered...
<h3>Importance</h3> Fine particles (particulate matter 2.5 μm [PM<sub>2.5</sub>]), a ubiquitous air pollutant, can deposit in the small airways that play vital role asthma. It appears to be unknown whether use of PM<sub>2.5</sub>filtration device improve airway physiology and respiratory inflammation children with <h3>Objective</h3> To discover what pathophysiological changes are associated using PM<sub>2.5</sub>-removing bedrooms <h3>Design, Setting, Participants</h3> Children mild or...
Kidney fibrosis is a common fate of chronic kidney diseases (CKDs), eventually leading to renal dysfunction. Yet, no effective treatment for this pathological process has been achieved. During the bioassay-guided chemical investigation medicinal plant Wikstroemia chamaedaphne, daphne diterpenoid, daphnepedunin A (DA), characterized as promising anti-renal fibrotic lead. DA shows significant anti-kidney effects in cultured fibroblasts and unilateral ureteral obstructed mice, being more potent...
Transient receptor potential (TRP) ankyrin 1 (TRPA1) could mediate ozone-induced lung injury. Optic Atrophy (OPA1) is one of the significant mitochondrial fusion proteins. Impaired fusion, resulting in dysfunction and ferroptosis, may drive onset progression In this study, we examined whether TRPA1 mediated bronchial epithelial cell injury by activating PI3K/Akt with involvement OPA1, leading to ferroptosis. Wild-type, TRPA1-knockout (KO) mice (C57BL/6 J background) ferrostatin-1...
Objectives: To test the feasibility of using a home-based sleep restriction protocol in adolescents and young adults; to examine different effects chronic on subjective sleepiness scale working memory task adults. Method: Twenty (ages 13–16 years) 20 adults 18–20 underwent 2-week manipulation consisting week 5 school days with 8 hr spent bed per night another 6 night. The used counterbalanced crossover experimental design. Subjective was scored by participant each morning, tests were...
Oxidative stress plays a role in the pathophysiology of emphysema through activation tissue proteases and apoptosis. We examined effects ozone exposure by exposing BALB/c mice to either single 3-h or multiple exposures over 3 6 wk, with two per week. Compared air-exposed mice, increase neutrophils bronchoalveolar lavage fluid lung inflammation index was greatest exposed for wk. Lung volumes were increased 3- 6-wk-exposed but not single-exposed. Alveolar space mean linear intercept 6-...
Ozone is an oxidizing environmental pollutant that contributes significantly to respiratory health. Exposure increased levels of ozone has been associated with worsening symptoms patients asthma and COPD (chronic obstructive pulmonary disease). In the present study, we investigated acute chronic effects exposure-induced oxidative stress-related inflammation mechanics in mouse lung. particular, stress-induced on HDAC2 (histone deacetylase 2) modification activation Nrf2 (nuclear factor...
High-efficiency particulate air (HEPA) filtration in combination with an electrostatic precipitator (ESP) can be a cost-effective approach to reducing indoor exposure, but ESPs produce ozone. The health effect of combined ESP-HEPA has not been examined. We conducted intervention study 89 volunteers. At baseline, the air-handling units offices and residences for all subjects were comprised coarse, ESP, HEPA filtration. During 5-week long intervention, split into 2 groups, 1 just ESP removed...
We show that an equity pairs trading strategy generates large and significant abnormal returns. find two components of the signal (i.e., short-term reversal momentum) have different dynamic cross-sectional properties. The momentum is largely explained by one-month version industry momentum. Therefore, profits are a online appendix available at https://doi.org/10.1287/mnsc.2017.2825 . This paper was accepted Lauren Cohen, finance.
Oxidative stress is a key mechanism underlying ozone-induced lung injury. Mitochondria can release mitochondrial reactive oxidative species (mtROS), which may lead to the activation of NLRP3 inflammasome. The goal this study was examine roles mtROS and inflammasome in acute airway inflammation bronchial hyperresponsiveness (BHR). C57/BL6 mice (n = 8/group) were intraperitoneally treated with vehicle (phosphate buffered saline, PBS) or mitoTEMPO (mtROS inhibitor, 20 mg/kg), orally VX-765...
Exposure to fine particulate matter (PM2.5) has been associated with lung inflammation and airway hyperresponsiveness (AHR). Transient receptor potential (TRP) vanilloid 1 (TRPV1) ankyrin (TRPA1) both may play important roles in AHR. We investigated whether PM2.5-induced AHR could be prevented by blocking TRPV1 TRPA1 channels. Mice were injected intraperitoneally AMG9810 (30 mg/kg, a antagonist) or A967079 their combination vehicle (PBS) one hour before intranasal instillation of PM2.5 (7.8...
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological pathological processes. Targeting by allosteric modulators represents a novel direction for therapeutics, which can overcome selectivity problem caused structural similarity of orthosteric sites among deacetylases. Here, developing reversed strategy AlloReverse, we identified cryptic site, Pocket Z, was only induced bi-directional signal triggered upon binding NAD+. Based on discovered an...