A5101580999- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Sarcoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Pancreatic and Hepatic Oncology Research
- Vascular Tumors and Angiosarcomas
- Retinoids in leukemia and cellular processes
- Gastric Cancer Management and Outcomes
- T-cell and Retrovirus Studies
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Traditional Chinese Medicine Analysis
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
University of Miami
2019-2024
Second Affiliated Hospital of Nanjing Medical University
2024
Affiliated Hospital of Nantong University
2024
Nantong University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Zhongnan Hospital of Wuhan University
2006-2023
Wuhan University
2006-2023
First Affiliated Hospital of Xiamen University
2023
Fujian Medical University
2023
Purpose Patients with acute myeloid leukemia (AML) who are in morphologic complete remission typically considered separately from patients active disease (ie, ≥ 5% marrow blasts by morphology) treatment algorithms for allogeneic hematopoietic cell transplantation (HCT), which implies distinct outcomes these two groups. It is well recognized that the presence of minimal residual (MRD) at time associated adverse post-HCT outcome those remission. This effect pre-HCT MRD prompted us to compare...
The presence of measurable residual disease after therapy is a significant risk factor relapse in patients with acute myeloid leukemia (AML). By detecting cells leukemia-associated immunophenotype (LAIP), multiparameter flow cytometry (MFC) can detect at level significantly lower than that detected by morphology. However, changes LAIPs during or may pose challenge to MRD testing. AML mutated NPM1 represents the largest subtype sharing common leukemogenic mechanism and similar LAIPs. Here, we...
Relapse is the major cause of death in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (HCT). Measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) before and HCT a strong, independent risk factor for relapse. As next-generation sequencing (NGS) increasingly applied AML MRD detection, it remains to be determined if NGS can improve prediction post-HCT Herein, we investigated pre-HCT MFC 59 adult NPM1-mutated...
Objectives: Primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) is a rare hematological malignancy with limited results on carcinogenesis and clinical characteristics. The aims of the current study were to examine mitotic arrest deficiency protein 2 (Mad2) expressions in PGI-DLBCL, assess its association Ki-67 expression, Helicobacter pylori (H. pylori) infection, BCL-6 gene rearrangement, clinicopathological variables.Methods: Cancer tissues from 38 PGI-DLBCL patients...
Systemic inflammation after heart valve replacement surgery commonly results in complications including cognitive impairment. This study was designed to investigate whether valvular disease itself and affects cognition the related functional connectivity (FC) of hippocampal memory network.
Essential thrombocythemia (ET) is characterized by thrombotic and hemorrhagic events. The association of clinical characteristics Chinese ET patients additional sex combs like 1 (ASXL1) mutations in these has remained to be elucidated. In the present study, 72 newly diagnosed were enrolled determine ASXL1 mutations. Mutations ASXL1, Janus kinase (JAK)2, calreticulin (CALR) myeloproliferative leukemia (MPL) genes detected using Sanger sequencing, data statistically analyzed. frequencies JAK2...
Tumor-associated macrophages play a critical role in the progression and immune response of triple-negative breast cancer (TNBC). Our study aimed to explore characteristics tumor-associated (TAMs) TNBC, construct risk signature associated with TAM clusters, verify its relationship prognosis immune-related characteristics. Firstly, we identified four clusters determined prognosis-related TNBC based on single-cell RNA sequencing (scRNA-seq) data. Subsequently, TAM-related prognostic genes were...
Objective: To observe the dynamic changes of serum cryptococcal capsular polysaccharide antigen (CrAg) titer and chest CT pulmonary cryptococcosis (PC) after antifungal therapy. Methods: A retrospective study was performed for patients with PC admitted to Department Pulmonary Critical Care Medicine First Affiliated Hospital Wenzhou Medical University from January 2015 April 2018. Serum CrAg titers Chest examination were all cases before treatment. The difference between immunocompetent hosts...
Introduction: H. pylori eradication rates have declined in concert with rising antimicrobial resistance worldwide. There is a need for rapid accurate, reliable antibiotic testing, especially refractory cases. Culture-based susceptibility testing requires endoscopic gastric biopsy, resultant inconvenience and costs. Molecular using next generation sequencing (NGS) of stool potentially allows prediction to all 6 commonly used antimicrobials. We aimed compare the results by NGS biopsy specimens...