A5100753273- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Gallbladder and Bile Duct Disorders
- Photoreceptor and optogenetics research
- Nutritional Studies and Diet
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Amino Acid Enzymes and Metabolism
- Adipose Tissue and Metabolism
- Phytoestrogen effects and research
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Biliary and Gastrointestinal Fistulas
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- Inflammasome and immune disorders
- Autism Spectrum Disorder Research
- Ginseng Biological Effects and Applications
Zhejiang University
2014-2025
Nanjing Medical University
2025
University of Malaya
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Nanjing Drum Tower Hospital
2024
Hohai University
2024
Hangzhou Normal University
2024
Yantai University
2024
Sir Run Run Shaw Hospital
2023
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2022-2023
Abstract Objectives Osteoporosis is a common bone disease in the elderly mainly regulated by osteoblasts (OBs) and osteoclasts (OCs). The gut microbiota has been recognized as an important factor many physiological pathological processes host. Thus, we hypothesize that necessary for postmenopausal osteoporosis germ‐free (GF) mice are protected from osteoporosis. Material Methods models were established performing ovariectomy (OVX) mice. Bone mass was measured micro‐CT, assessed 16s rDNA...
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology hepatic IR injury, effective interventions therapeutics are still lacking. Here, we examined role transient receptor potential melastatin 2 (TRPM2), Ca2+-permeable, non-selective cation channel, mediating injury. Our data showed TRPM2 deficiency attenuated IR-induced dysfunction, inflammation, cell death...
Abstract Accumulating evidence suggests that aquaporins (AQPs) may facilitate tumor development. The molecular pathways connecting the pathological functions of AQPs are unclear and need to be better defined. This study aimed investigate whether AQP3, one expressed highly in breast cancer, had any clinical implication estrogen-receptor (ER) positive cancer explore regulatory mechanisms AQP3 estrogen-related progression. Here we show is an important enforcer migration invasion cancer. We, for...
Regulated cell death and xenophagy constitute fundamental cellular mechanisms against invading microorganisms. Staphylococcus aureus, a notorious pathogen, can invade persist within host cells for extended periods. Here, we describe novel mechanism by which S. aureus subverts these defenses through the manipulation of CASP8 (caspase 8) signaling pathway. Upon invasion, triggers assembly RIPK3 (receptor interacting serine/threonine kinase 3) complex to induce autoprocessing. However,...
The objective was to investigate the regulatory effect of polyunsaturated fatty acids (PUFAs) on mRNA expression key genes involved in homocysteine (Hcy) metabolism. Eighty male Sprague Dawley rats were randomly divided into eight groups. oils orally administered daily for 8 weeks. Plasma Hcy, phospholipids acids, and determined. Compared with control group, plasma Hcy significantly decreased 22:6 n ‐3 conjugated linoleic acid (CLA) groups; Mthfr upregulated ‐3, 20:5 18:3 groups...
Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved remains be fully elucidated. A high-fat-diet (HFD) pregnant rat model was used investigate whether excessive intrauterine lipid exposure associated with elevated blood pressure and increased levels of leptin, an important biomarker mediator vascular dysfunction hypertension. We found that gestational hyperlipidemia predisposed elevation...
Human renal cell carcinoma which is a highly vascular tumor the leading cause of death from urologic cancers. Angiogenesis has pivotal role in oncogenesis and viability expansion carcinoma. Rap2B, as small guanosine triphosphate-binding protein Ras family, was first discovered early 1990s during screening platelet complementary DNA library. Previous studies have shown that Rap2B aberrantly expressed human carcinogenesis promoted development tumors via multiple signaling pathways. However,...