A5100323580- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Signaling Pathways in Disease
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Dermatological and Skeletal Disorders
- Cancer, Hypoxia, and Metabolism
- High Altitude and Hypoxia
- Heterotopic Ossification and Related Conditions
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Axon Guidance and Neuronal Signaling
- Dermatological diseases and infestations
- Autoimmune Neurological Disorders and Treatments
- FOXO transcription factor regulation
- Clostridium difficile and Clostridium perfringens research
- Zebrafish Biomedical Research Applications
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2012-2025
Air Force Medical University
2013-2024
Binzhou University
2023-2024
Binzhou Medical University
2023-2024
Xijing Hospital
2021-2023
Northwest University
2021-2022
West China Hospital of Sichuan University
2021
Sichuan University
2021
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020
Abstract In face of the everlasting battle toward COVID-19 and rapid evolution SARS-CoV-2, no specific effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme 2 (ACE2), a receptor mediates virus infection by binding to spike protein. Although ACE2 is expressed in lung, kidney, intestine, its expressing levels are rather low, especially lung. Considering great infectivity COVID-19, we speculate that SARS-CoV-2 may depend on other routes...
Pathological cartilage calcification plays an important role in osteoarthritis progression but which the origin of calcified extracellular vesicles (EVs) and their effects remain unknown. Here, we demonstrate that pathological occurs early stage EVs are closely involved. Autophagosomes carrying minerals released EVs, is induced by those autophagy-regulated EVs. Autophagy-derived microtubule-associated proteins 1A/1B light chain 3B (LC3)-positive major population initiate calcification....
Abstract Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport over long range, its physiological roles outside are largely elusive 1,2 . Here we found chondrocytes produced massive amounts form eosin-positive bodies their cytoplasm. The body (Hedy) membraneless condensate characterized by phase separation. Production controlled hypoxia and dependent on KLF1 rather than the HIF1/2α pathway. Deletion leads Hedy loss along with severe hypoxia, enhanced...
Objective— To determine the role of orai1 store–operated Ca 2+ entry in foam cell formation and atherogenesis. Approach Results— Acute administration oxidized low-density lipoprotein (oxLDL) activates an orai1-dependent macrophages. Chelation intracellular , inhibition entry, or knockdown dramatically inhibited oxLDL-induced upregulation scavenger receptor A, uptake modified LDL, formation. Orai1-dependent induces A expression through activation calcineurin but not calmodulin kinase II....
Evidence supports an important role of Ca 2+ release-activated channel protein 1 (Orai1)-mediated entry in the development renal fibrosis, a common pathologic feature CKDs that lead to ESRD, but molecular mechanisms remain unclear. We determined Orai1 calcium fibrosis induced by high-fat diet and unilateral ureteral obstruction. Mouse kidneys with had higher levels expression than did without fibrosis. In vivo knockdown adenovirus harboring Orai1–short hairpin RNA or inhibition SKF96365...
Tat-CIRP perturbed the function of MD2 and provided robust neuroprotection in cells, rodents, gyrencephalic nonhuman primates.
Abstract Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found calcified apoptotic vesicles (apoVs) led to increased calcification and stiffness tendon extracellular matrix (ECM), which initiated M2 macrophage polarization progression. Specifically, single‐cell transcriptome analyses different stages revealed apoVs were primarily secreted by a PROCR + fibroblast population. In...
Acupoint catgut embedding (ACE) is a traditional Chinese medicine technique commonly used for managing various disorders, including chronic inflammatory pain and allergic asthma. Despite its growing use, the neuroimmunological mechanisms underlying ACE treatment effects remain unclear. This study investigated roles potential of in treating experimental autoimmune encephalomyelitis (EAE), frequently animal model neuroinflammation. The were evaluated by monitoring body weight EAE severity...
Background: Membranous glomerulonephritis (MGN) is a nephrotic syndrome which shows the symptoms of heavy proteinuria and immune complex deposition in glomerular sub-epithelial space finally leads to chronic kidney disease. Isoliquiritin (ILQ) flavonoid with wide range pharmacological properties, including antioxidant anti-inflammatory activity. The present study was undertaken investigate possible mechanisms by ILQ ameliorates cationic bovine serum albumin (C-BSA) induced MGN rat model....
Abstract Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore presynaptic role CCL2. Behavioral experiments show intervertebral foramen injection CCR2 antagonists into dorsal root ganglion (DRG) can inhibit inflammatory pain caused by in spinal cord. We raised question horn. Subsequent electron microscopy showed was expressed CGRP terminal enhance calcium signal. Whole-cell patch-clamp...
The pre-Bötzinger complex (PBC), thought to be the center of respiratory rhythm generation, is a cell column ventrolateral nucleus ambiguus. present study analyzed its cellular and neurochemical composition in adult rats. PBC neurons were mainly oval, fusiform, or multipolar shape small medium size. Neurokinin-1 receptor, marker PBC, was plasma membrane mostly their associated processes boutons. Among immunoreactive for different neurotransmitter receptor candidates, various numbers...
Increased transendothelial permeability and subsequent blood-brain barrier damage play a key role in the pathological progression of human brain ischemia secondary reperfusion. Memantine is licensed drug providing clinically relevant efficacy patients with Alzheimer's disease. However, little information known regarding its effects on endothelial permeability. In this study, we investigated memantine underlying mechanisms an ischemia-reperfusion (I/R) injury model primary microvascular...
Natural killer (NK) cells are a type of innate lymphoid cell that involved in the progression acute myocardial infarction and ischemic stroke. Although multiple forms programmed death known to play important roles these diseases, correlation between NK apoptosis-related genes during stroke remains unclear. In this study, we explored distinct patterns infiltration apoptosis pathological using mRNA expression microarrays from Gene Expression Omnibus database. Since abundance correlated...
Abstract Patients with tissue inflammation or injury often experience aberrant mechanical pain hypersensitivity, one of leading symptoms in clinic. Despite this, the molecular mechanisms underlying distortion are poorly understood. Canonical transient receptor potential (TRPC) channels confer sensitivity to stimulation. TRPC3 and TRPC6 proteins, coassembling as heterotetrameric channels, highly expressed sensory neurons. However, how these mediate hypersensitivity has remained elusive. It is...
Abstract Nogo‐A is known to be a myelin‐associated protein with strong inhibitory effect on neurite outgrowth and has been considered one of the major factors that hinder fiber regeneration in central nervous system. Recent studies have demonstrated widespread occurrence nogo‐A mRNA neurons. Our concurrent immunohistochemical study substantiated distribution neuronal Nogo‐A. The present was thus focused its intraneuronal system, using Western blotting, immunohistochemical, immunogold...
We utilized cytochrome oxidase (CO) as a marker of neuronal functional activity to examine metabolic changes in brain stem respiratory nuclei rats from newborn 21 day age. The pre-Bötzinger complex (PBC), upper airway motoneurons nucleus ambiguus (NA(UAM)), ventrolateral solitary tract (NTS(VL)), and medial lateral parabrachial (PB(M) PB(L), respectively) were examined at postnatal days (P) 0, 1, 2, 3, 4, 5, 7, 14, 21. CO histochemistry was performed, the intensity reaction product...
Abstract Our previous studies have demonstrated that neurokinin‐1 receptor (NK1R)‐immunoreactive (ir) neurons in the pre‐Bötzinger Complex (pre‐BötC), hypothesized kernel of respiratory rhythmogenesis, receive both glutamatergic excitatory and GABAergic or glycinergic inhibitory inputs. Neuromodulators, such as substance P (SP) opioids, play important roles normal activity disorders. The identification relationship between neurotransmitters NK1R‐ir at cellular level is essential for...
J. Neurochem . (2012) 122 , 923–933. Abstract The pre‐Bötzinger complex (pre‐BötC) in the ventrolateral medulla oblongata is critical for generation of respiratory rhythm mammals. Somatostatin (SST) and neurokinin 1 receptor (NK1R) immunoreactivity have been used as markers pre‐BötC. SST almost completely overlaps with small fusiform NK1R‐immunoreactive (ir) neurons, presumed rhythmogenic but not large multipolar NK1R‐ir neurons. Understanding neurochemical characteristics, especially...