A5060748151- Neurogenesis and neuroplasticity mechanisms
- Microtubule and mitosis dynamics
- Nerve injury and regeneration
- Developmental Biology and Gene Regulation
- Muscle Physiology and Disorders
- Ubiquitin and proteasome pathways
- Silk-based biomaterials and applications
- Axon Guidance and Neuronal Signaling
- Aquaculture disease management and microbiota
- X-ray Diffraction in Crystallography
- Invertebrate Immune Response Mechanisms
- Plant Pathogens and Fungal Diseases
- RNA regulation and disease
- Crystallization and Solubility Studies
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Spinal Cord Injury Research
- Signaling Pathways in Disease
- Flavonoids in Medical Research
- Aquaculture Nutrition and Growth
Nantong University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Wuhan Hankou Hospital
2021-2025
Zhejiang Institute of Freshwater Fisheries
2019-2024
Anhui Science and Technology University
2024
Anhui University of Science and Technology
2024
Ocean University of China
2003-2024
Fujian Agriculture and Forestry University
2024
Qingdao National Laboratory for Marine Science and Technology
2024
Laoshan Laboratory
2024
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription containing an inducibly expressed HIF-1α subunit and constititutively HIF-1β subunit. Under hypoxic conditions, the accumulates due to decrease in rate of proteolytic degradation, resulting HIF-1α-HIF-1β heterodimers undergo posttranslational modifications that promote transactivation. Recent studies suggest amplified signaling through phosphoinositide 3-kinase, its downstream target, mTOR, enhances HIF-1-dependent gene...
Abstract Reptiles are the most morphologically and physiologically diverse tetrapods, have undergone 300 million years of adaptive evolution. Within reptilian geckos possess several interesting features, including ability to regenerate autotomized tails climb on smooth surfaces. Here we sequence genome Gekko japonicus (Schlegel’s Japanese Gecko) investigate genetic elements related its physiology. We obtain a draft G. 2.55 Gb annotated 22,487 genes. Comparative genomic analysis reveals...
Abstract Easy cancer recurrence and wound infections have been clinical challenges after surgical treatment of melanoma. Herein, a silk‐inspired in situ gelation system containing methacrylated silk fibroin (SF) chlorine e6 for improved therapy with enhanced healing is developed. Favored by the macrophage recruitment capacity SF hydrogel, promising antitumor immune responses can be turned “on” via near infrared irradiation controllable manner to achieve combination photodynamic significantly...
Abstract Due to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective modulation SCI‐specific inflammatory pathogenesis achieve desirable therapeutic effects on functional recovery still remains challenging. Herein, cell‐enhanced photocrosslinked silk fibroin hydrogels with extracellular matrix‐mimicking cues mechanical properties and RGD (Arg‐Gly‐Asp) signals are gelled in situ fill lesion site modulate injury‐induced neuroinflammation promote neurite regrowth...
Kinesin-12 (also called Kif15) is a mitotic motor protein that continues to be expressed in developing neurons. Depletion of kinesin-12 causes axons grow faster, more than doubles the frequency microtubule transport both directions axon, prevents growth cones from turning properly, and enhances invasion microtubules into filopodia. These results are remarkably similar those obtained previous studies which neurons were depleted kinesin-5 Eg5 or Kif11), another However, there also notable...
Microtubules are nearly uniformly oriented in the axons of vertebrate neurons but non-uniformly their dendrites. Studies to date suggest a scenario for establishing these microtubule patterns whereby microtubules transported into axon and nascent dendrites with plus-ends-leading, then additional opposite orientation developing Here, we used contemporary tools confirm that depletion kinesin-6 (also called CHO1/MKLP1 or kif23) from rat sympathetic causes reduction appearance minus-end-distal...
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae five other genomes pathogens. Botryosphaeriaceous showed expansion gene families associated with cell wall degradation, nutrient uptake, secondary metabolism membrane...
Summary Background In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI 3K/ AKT /caspase 3 pathway are strongly implicated in dopaminergic neuronal death P arkinson's disease ( PD ). This study aims investigate how simvastatin affects 6‐hydroxydopamine‐lesioned PC 12 via regulating modulating inflammatory mediators. Methods 6‐hydroxydopamine‐treated cells were used neuroprotection of...
Large, non-coding pentanucleotide repeat expansions of ATTCT in intron 9 the ATXN10 gene typically cause progressive spinocerebellar ataxia with or without seizures and present neuropathologically Purkinje cell loss resulting symmetrical cerebellar atrophy. These can be interrupted by sequence motifs which have been attributed to are likely act as genetic modifiers. We identified a Mexican kindred multiple affected family members expansions. Four showed clinical features type 10 (SCA10)....
The formation of interstitial axonal branches involves the severing microtubules at sites where new form. Here we wished to ascertain whether basic fibroblast growth factor (bFGF) enhances branching through alterations in proteins involved microtubules. We found that treatment cultured hippocampal neurons with bFGF heightens expression both katanin and spastin, which are sever axon. In addition, phosphorylation tau expected cause it dissociate from This is important because regulates access...
Discovering safe and effective drugs that promote neuron regeneration is an essential strategy for the recovery of central nervous system injuries. In this study, we found L-leucine, amino acid obtained from both supplements food sources, could dramatically boost axonal outgrowth regeneration. First, effects L-leucine on neurons were evaluated by cell apoptosis, survival, death assays, results showed no changes in these processes after treatment. By live imaging, was to remarkably increase...