A5100351050- Extracellular vesicles in disease
- Silk-based biomaterials and applications
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Neurobiology and Insect Physiology Research
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Signaling Pathways in Disease
- RNA regulation and disease
- Immune cells in cancer
- Gut microbiota and health
- Invertebrate Immune Response Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Ubiquitin and proteasome pathways
- Plant Reproductive Biology
- Zebrafish Biomedical Research Applications
- RNA Research and Splicing
- Wound Healing and Treatments
- Genetics and Neurodevelopmental Disorders
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Nantong University
2015-2024
Shanghai Jiao Tong University
2023-2024
XinHua Hospital
2023-2024
Affiliated Hospital of Nantong University
2021-2023
Guangxi Medical University
2020-2023
University of Science and Technology of China
2023
Third Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Peripheral nerve injury is a common clinical problem. Nerve growth factor (NGF) promotes peripheral regeneration, but its applications are limited by several constraints. In this study, we found that the time-dependent expression profiles of eight let-7 family members in injured after sciatic were roughly similar to each other. Let-7 microRNAs (miRNAs) significantly reduced cell proliferation and migration primary Schwann cells (SCs) directly targeting NGF suppressing protein translation....
Immunosuppressive tumor microenvironment (ITM) remains an obstacle that jeopardizes clinical immunotherapy.
Abstract Due to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective modulation SCI‐specific inflammatory pathogenesis achieve desirable therapeutic effects on functional recovery still remains challenging. Herein, cell‐enhanced photocrosslinked silk fibroin hydrogels with extracellular matrix‐mimicking cues mechanical properties and RGD (Arg‐Gly‐Asp) signals are gelled in situ fill lesion site modulate injury‐induced neuroinflammation promote neurite regrowth...
The cisplatin resistance of non-small cell lung cancer (NSCLC) patients results in low response rate and overall survival rate. Exosomes contribute to pathological processes multiple cancers.
Diabetic nephropathy (DN) is a common complication of diabetes mellitus which can result in renal failure and severely affect public health. Several studies have revealed the important role podocyte injury DN progression. Although, involvement exosomes derived from M2 macrophages has been reported injury, underlying molecular mechanism macrophage-secreted not fully elucidated. Our study suggests that mitigate lipopolysaccharide (LPS)-induced podocytes via exosomes. Moreover, we observed...
Abstract Reactive oxygen species (ROS) participate in various physiological and pathological functions following generation from different types of cells. Here we explore ROS on spontaneous tail regeneration using gecko model. were mainly produced the skeletal muscle after amputation, showing a temporal increase as proceeded. Inhibition production influenced formation autophagy muscles, consequence, length regenerating tail. Transcriptome analysis has shown that NADPH oxidase (NOX2) subunits...
A central question in neural tissue engineering is how the tissue-engineered nerve (TEN) translates detailed transcriptional signals associated with peripheral regeneration into meaningful biological processes. Here, we report a skin-derived precursor-induced Schwann cell (SKP-SC)-mediated chitosan/silk fibroin-fabricated graft (SKP-SCs-TEN) that can promote sciatic and functional restoration nearly to levels achieved by autologous grafts according behavioral, histological,...
Dexamethasone sodium phosphate (Dex) is widely used in the clinic for treatment of rheumatoid arthritis. However, it circulates blood a short time and linked to high risk severe side effects caused by repeated dosing. Here, we encapsulated Dex onto zeolitic imidazolate framework-8 (ZIF-8) prepare metal–organic framework nanoparticles with drug loading efficiency. To prevent clearance mononuclear phagocyte system extend circulation, were also camouflaged macrophage-derived microvesicles (MV)...
Kinesin‐12 (also called KIF15) is a microtubule‐based motor protein best known for its role in cell division. We previously reported that kinesin‐12 robustly expressed developing terminally post‐mitotic neurons, with levels diminishing as neurons reach maturity. found axons of cultured rodent grow faster and longer if experimentally depleted, leading us to conclude plays modulating axonal growth. Here we used zebrafish explore whether these results apply an vivo system they across different...
It has been shown that material surface topography greatly affects cell attachment, growth, proliferation, and differentiation. However, the underlying molecular mechanisms for cell–material interactions are still not understood well. Here, two kinds of butterfly wings with different architectures were employed addressing such an issue. Papilio ulysses telegonus (P.u.t.) wing is composed micro/nanoconcaves, whereas Morpho menelaus (M.m.) decorated grooves. RSC96 cells grown on M.m. showed a...
Glucose-dependent insulinotropic polypeptide (GIP) is a ligand of glucose-dependent receptor (GIPR) that plays an important role in the digestive system. In recent years, GIP has been regarded as hormone-like peptide to regulate local metabolic environment. this study, we investigated antioxidant on neuron and explored possible mechanism.
Microparticles (MPs) are cell–cell communication vesicles derived from the cell surface plasma membrane, although they not known to originate cardiac ventricular muscle. In cardiomyocytes, membrane deformation protein bridging integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tubule (t-tubule) microfolds, which facilitate ion channel trafficking and modulate local ionic concentrations. The microfold-generated microdomains continuously reorganize, adapting in response stress calcium...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory in joints. Invasive pannus a characteristic pathological feature of RA. RA fibroblast-like synoviocytes (FLSs) are showed tumor-like biological characters that facilitate generation. Importantly, it has been documented extracellular vesicle (EVs) derived microRNAs have vital role angiogenesis various immune diseases. However, whether FLSs EVs can and the underlying mechanism undefined. Herein, we aim to...
Spider silk is a biomaterial with superior properties. However, its heterologous expression template hard to construct.
Abstract Background Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with high incidence in China. The molecular mechanisms vasculogenic mimicry (VM) angiogenesis are not fully elucidated NPC. More specially, it has seldomly been reported that Epstein–Barr virus‐encoded miRNA can regulate VM aim this study was to investigate the function mechanism targeting exosome system (iRGD‐exo‐antagomiR) against NPC, provide new approaches for improving comprehensive treatment Methods...
Several adult reptiles, such as Gekko japonicus, have the ability to precisely re-create a missing tail after amputation. To ascertain associated acquisition of positional information from blastemal cells and underlying molecular mechanism regeneration, candidate molecule CD59 was isolated gecko. transcripts displayed graded expression in gecko spinal cord with highest level anterior segment, stable along normal tail. After amputation, proximal injury sites increased markedly at 1 day 2...