A5020505942- Circadian rhythm and melatonin
- Remote Sensing in Agriculture
- Genetic and rare skin diseases.
- RNA regulation and disease
- Neurobiology and Insect Physiology Research
- melanin and skin pigmentation
- Nerve injury and regeneration
- Insect Resistance and Genetics
- Smart Agriculture and AI
- Immunotherapy and Immune Responses
- Leaf Properties and Growth Measurement
- Insect and Arachnid Ecology and Behavior
- Cancer and Skin Lesions
- Insect-Plant Interactions and Control
- Species Distribution and Climate Change
- Signaling Pathways in Disease
- Kruppel-like factors research
- TGF-β signaling in diseases
- SARS-CoV-2 and COVID-19 Research
- Spectroscopy and Chemometric Analyses
- Cancer-related molecular mechanisms research
- Remote Sensing and Land Use
- Date Palm Research Studies
- Plant Gene Expression Analysis
- RNA and protein synthesis mechanisms
Chinese Academy of Sciences
2017-2025
Aerospace Information Research Institute
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Institute of Solid State Physics
2025
Heilongjiang Bayi Agricultural University
2025
University of Chinese Academy of Social Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Zhejiang University
2024
Chinese Academy of Social Sciences
2024
Dalian Municipal Central Hospital
2024
Progressive tissue fibrosis is a cause of major morbidity and mortality. Pulmonary an epithelial-mesenchymal disorder in which TGF-β1 plays central role pathogenesis. Here we show that follistatin-like 1 (FSTL1) differentially regulates TGF-β bone morphogenetic protein signaling, leading to epithelial injury fibroblast activation. Haplodeletion Fstl1 mice or blockage FSTL1 with neutralizing antibody reduced bleomycin-induced vivo. induced response lung promotes the accumulation...
With the development of globalization and agriculture trade, as well its own strong migratory capacity, fall armyworm (FAW) (
The desert locust (Schistocerca gregaria) is a destructive migratory pest, posing great threat to over 60 countries globally. In the backdrop of climate change, habitat suitability locusts poised undergo alterations. Hence, investigating shifting dynamics habitats holds profound significance in ensuring global agricultural resilience and food security. this study, we combined maximum entropy modelling geographic information system technology conduct comprehensive analysis impact change on...
Abstract Depression is a disturbing psychiatric disease with unsatisfied therapy. Not all patients are sensitive to anti-depressants currently in use, side-effects unavoidable during therapy and the cases effectiveness always accompanied delayed onset of clinical efficacy. Delivering brain-derived neurotrophic factor (BDNF) brain seems be promising However, better approach delivery still rudimentary. The purpose our present work look for rapid-onset long-lasting therapeutic strategy major...
Abstract Sb 2 S 3 solar cells have significant advantages in non‐toxicity and stability compared to perovskite cells. However, their power conversion efficiency still needs be improved urgently. One of the main reasons is that crystal orientation 2D difficult control, there are a large number dangling bonds at surface, which make it for photogenerated charges efficiently conduct desired direction causes serious charge recombination. In order overcome various challenges, including core...
Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Recent reports of increased matrix metalloproteinase-2 (MMP-2) in lungs patients with emphysema support the paradigm proteinase/antiproteinase imbalance pathogenesis COPD. We sought to define signaling pathways activated by smoke and identify molecules responsible emphysema-associated MMP-2 expression. In this study, we show that cigarette extract (CSE) induced protein expression gelatinase activity...
The first fall armyworm (FAW; Spodoptera frugiperda) attack in Yunnan, China, occurred January 2019. Because FAW lacks diapause ability, its population outbreaks largely depend on environmental conditions experienced during the overwinter months. Thus, there is an urgent need to make short-term predictions regarding potential overwintering distribution of prevent outbreaks. In this study, we selected MaxEnt model with optimal parameter combination predict Yunnan. Remote sensing data were...
In the core mammalian circadian negative feedback loop, BMAL1-CLOCK complex activates transcription of genes Period (Per) and Cryptochrome (Cry). To close PER-CRY interacts with to repress its activity. These two processes are separated temporally ensure clock function. Here, we show that histone deacetylase 3 (HDAC3) is a critical component loop by regulating both activation repression in activity-independent manner. Genetic depletion Hdac3 results low-amplitude rhythms dampened...
Post-stroke depression (PSD) is one of the most frequent neuropsychiatric disorders associated with stroke characterized by depression. The neuroplasticity hypothesis postulates that loss brain-derived neurotrophic factor (BDNF) plays a major role in pathophysiology PSD, and restoration it may represent critical mechanism underlying antidepressant efficacy.In previous studies, we designed new fusion gene, HA2TAT-BDNF, cloned into adenovirus virus (AAV) to construct BDNF-HA2TAT/AAV for...
Damage in COVID-19 results from both the SARS-CoV-2 virus and its triggered overactive host immune responses. Therapeutic agents that focus solely on reducing viral load or hyperinflammation fail to provide satisfying outcomes all cases. Although cellular factors have been extensively profiled identify potential anti-COVID-19 targets, new drugs with significant efficacy remain be developed. Here, we report potent preclinical of ALD-R491, a vimentin-targeting small molecule compound, treating...
Oxidative stress is considered a major determinant in the pathogenesis of vitiligo. Methylcobalamin (MeCbl) an activated form vitamin B12 that regulates inflammatory factors, counters oxidative stress, and reduces apoptosis many disease models. However, specific mechanism MeCbl repigmentation against vitiligo unknown. In this study, we explored effect on melanocytes following hydrogen peroxide (H2O2)-induced stress.We established model using immortalized human normal melanocyte cell line...
Several adult reptiles, such as Gekko japonicus, have the ability to precisely re-create a missing tail after amputation. To ascertain associated acquisition of positional information from blastemal cells and underlying molecular mechanism regeneration, candidate molecule CD59 was isolated gecko. transcripts displayed graded expression in gecko spinal cord with highest level anterior segment, stable along normal tail. After amputation, proximal injury sites increased markedly at 1 day 2...
Monitoring the vertical profile of leaf chlorophyll (Chl) content within winter wheat canopies is significant importance for revealing real nutritional status crop. Information on Chl not accessible to nadir-viewing remote or proximal sensing. Off-nadir multi-angle sensing would provide effective means detect in different layers. However, adequate information selection sensitive spectral bands and index formulas estimation yet available. In this study, all possible two-band three-band...
Circadian systems provide a fitness advantage to organisms by allowing them adapt daily changes of environmental cues, such as light/dark cycles. The molecular mechanism underlying the circadian clock has been well characterized. However, how internal clocks are entrained with regular cycles remains unclear. By collecting and analyzing indirect calorimetry (IC) data from more than 2000 wild-type mice available International Mouse Phenotyping Consortium (IMPC), we show that onset time peak...
The fall armyworm (FAW) (Spodoptera frugiperda) (J. E. Smith) is a migratory pest that lacks diapause and has raised widespread concern in recent years due to its global dispersal infestation. Seasonal environmental changes lead large-scale seasonal activities, quantitative simulations of patterns spatiotemporal distribution facilitate integrated management. Based on remote sensing data meteorological assimilation products, we constructed mechanistic model the dynamic FAW (FAW-DDM) by...