A5100776772- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Ubiquitin and proteasome pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Advanced Surface Polishing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Traditional Chinese Medicine Analysis
- Advanced Battery Technologies Research
- Atherosclerosis and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- GDF15 and Related Biomarkers
Chinese Academy of Sciences
2002-2025
University of Chinese Academy of Sciences
2023-2025
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Union Hospital
2015-2025
National Yang Ming Chiao Tung University
2017-2025
Taipei Veterans General Hospital
2012-2025
Nanjing University
2025
Shanghai Ninth People's Hospital
2022-2025
Shanghai Jiao Tong University
2022-2025
Objective: To explore the clinical characteristics and prognosis of new coronavirus 2019-nCoV patients combined with cardiovascular disease （CVD). Methods: A retrospective analysis was performed on 112 COVID-19 CVD admitted to western district Union Hospital in Wuhan, from January 20, 2020 February 15, 2020. They were divided into critical group (ICU, n=16) general (n=96) according severity followed up endpoint. The observation indicators included total blood count, C-reactive protein (CRP),...
Argonaute 2 (AGO2), the core component of microRNA (miRNA)-induced silencing complex, plays a compelling role in tumorigenesis and aggressiveness. However, mechanisms regulating functions AGO2 cancer still remain elusive. Herein, we indentify one intronic circular RNA (circRNA) generated from gene (circAGO2) as novel regulator AGO2-miRNA complexes progression. CircAGO2 is up-regulated gastric cancer, colon prostate neuroblastoma, associated with poor prognosis patients. promotes growth,...
Background: FUN14 domain containing 1 (FUNDC1) is a highly conserved outer mitochondrial membrane protein. The aim of this study to examine whether FUNDC1 modulates the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), morphology, and function in cardiomyocytes intact hearts. Methods: impacts on MAMs formation cardiac functions were studied mouse neonatal cardiomyocytes, mice with cardiomyocyte-specific Fundc1 gene knockout ( f/Y /Cre αMyHC+/− ), tissues patients heart...
Toll-like receptors (TLRs) are a family of pattern recognition (PRR) with crucial function in innate immune responses. Activation TLR4 signaling at the plasma membrane by lipopolysaccharide (LPS) stimulates proinflammatory pathways dependent on E3 ubiquitin ligase TRAF6. Here we show LPS-induced long non-coding RNA (lncRNA) Mirt2 functions as checkpoint to prevent aberrant activation inflammation, and is potential regulator macrophage polarization. associates with, attenuates Lys63...
ST-segment elevation myocardial infarction (STEMI) is a fatal cardiovascular emergency requiring rapid reperfusion treatment. During the coronavirus disease-2019 (COVID-19) pandemic, medical professionals need to strike balance between providing timely treatment for STEMI patients and implementing infection control procedures prevent nosocomial spread of COVID-19 among health care workers other vulnerable patients.This study evaluates impact outbreak China Chest Pain Center's modified...
Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum membranes (MAMs). The roles of MAMs in diabetic hearts remain unknown. aims this study, therefore, were to determine whether the diabetes mellitus–induced expression could increase MAM formation, disruption formation improves cardiac function. Methods: Levels FUNDC1 examined from patients nondiabetic donors. Fundc1-induced heart...
Abstract Myocardial microRNAs (myo-miRs) are released into the circulation after acute myocardial infarction (AMI). How they impact remote organs is however largely unknown. Here we show that circulating myo-miRs carried in exosomes and mediate functional crosstalk between ischemic heart bone marrow (BM). In mice, find AMI accompanied by an increase levels of myo-miRs, with miR-1, 208, 499 predominantly miR-133 non-exosomal component. Myo-miRs imported selectively to peripheral...
In this study, we aimed to clinically and genetically characterize LVNC patients investigate the prevalence of variants in known novel disease genes.Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause heart failure, arrhythmia, thromboembolism, sudden cardiac death. We sought here dissect its genetic causes, phenotypic presentation outcome.In our registry with follow-up median 61 months, analysed 95 (68 unrelated index 27 affected relatives; definite...
Circular RNAs (circRNAs), a subclass of non-coding RNAs, play essential roles in tumorigenesis and aggressiveness. Our previous study has identified that circAGO2 drives gastric cancer progression through activating human antigen R (HuR), protein stabilizing AU-rich element-containing mRNAs. However, the functions underlying mechanisms circRNAs derived from HuR remain elusive.CircRNAs were detected by real-time quantitative RT-PCR validated Sanger sequencing. Biotin-labeled RNA pull-down,...
Diabetic osteoporosis (DOP) is the leading complication continuously threatening bone health of patients with diabetes. A key pathogenic factor in DOP loss osteocyte viability. However, mechanism death remains unclear. Here, we identified ferroptosis, which iron-dependent programmed cell death, as a critical murine models DOP. The diabetic microenvironment significantly enhanced ferroptosis vitro, shown by substantial lipid peroxidation, iron overload, and aberrant activation pathway. RNA...
Abstract Prelithiation technology is widely considered a feasible route to raise the energy density and elongate cycle life of lithium‐ion batteries. The principle prelithiation introduce extra active Li ions in battery so that lithium loss during first charge long‐term cycling can be compensated. Such an effect does not need change major electrode material or structure compatible with majority current production lines. At this stage, various methods have been reported, some which are...
Abstract The composition of the solid electrolyte interphase (SEI) is crucial to stably operate solid‐state batteries based on lithium‐metal anodes. In this work, redox state PVDF‐ b ‐PTFE (PVT) polymer regulated by introducing fully conjugated copper polyphthalocyanine metal (CuPcLi), improving electron transfer kinetics accelerate decomposition fluorinated ingredients. As a result, an effective SEI with enriched lithium fluoride forms in situ at Li/electrolyte interface, which enhances...
Abstract The growth of lithium dendrites hinders the commercial applications lithium‐metal batteries. Electrolytes play a crucial role in influencing electrode/electrolyte interfacial chemistry. Traditional electrolytes adopt strongly solvating solvents to dissolve Li salts, creating an organic‐rich solid electrolyte interface (SEI). + conductivity and mechanical strength SEI are poor, so derived cannot effectively suppress dendrites. weakly (WSE) system can realize inorganic‐rich SEI,...
Abstract Difficult-to-machine materials (DMMs) are extensively applied in critical fields such as aviation, semiconductor, biomedicine, and other key due to their excellent material properties. However, traditional machining technologies often struggle achieve ultra-precision with DMMs resulting from poor surface quality low processing efficiency. In recent years, field-assisted (FAM) technology has emerged a new generation of based on innovative principles laser heating, tool vibration,...
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that expressed by vascular endothelial cells tumor the human microenvironment. Administration overexpression murine enhanced cell growth vivo, respectively. stimulated sphere formation prevented chemotherapy-induced apoptosis. Mechanistically, activated core stem genes NANOG, NOTCH3, OCT3/4 via ST2 signaling pathway, induced phosphorylation c-Jun N terminal kinase (JNK) activation binding...
The gut-liver axis is associated with the progression of non-alcoholic fatty liver disease (NAFLD). Targeting and bile acid-based pharmaceuticals are potential therapies for NAFLD. effect tauroursodeoxycholic acid (TUDCA), a candidate drug NAFLD, on intestinal barrier function, inflammation, gut lipid transport microbiota composition was analysed in murine model NAFLD.The NAFLD mouse established by feeding mice high-fat diet (HFD) 16 weeks. TUDCA administered p.o. during last 4 expression...
Circular RNAs (circRNA), a subclass of noncoding RNA characterized by covalently closed continuous loops, play emerging roles in tumorigenesis and aggressiveness. However, the functions underlying mechanisms circRNA regulating Wnt/β-catenin signaling cancer progression remain elusive. Here, we screen cis-acting generated β-catenin (CTNNB1)/transcription factor 7-like 2 genes identify one intronic derived from CTNNB1 (circ-CTNNB1) as novel driver progression. Circ-CTNNB1 was predominantly...
Abstract Matrix metalloproteinase (MMP)-14 is the only membrane-anchored MMP that plays a critical role in tumor metastasis and angiogenesis. However, mechanisms underlying MMP-14 expression tumors still remain largely unknown. In this study, immunostaining was identified 29/42 neuroblastoma tissues, which correlated with clinicopathologic features shorter patients' survival. subtotal 20 cases, microRNA 9 (miR-9) downregulated inversely expression. Bioinformatics analysis revealed putative...