A5083685156- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- Cardiac Ischemia and Reperfusion
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- NF-κB Signaling Pathways
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Signaling Pathways in Disease
- Advanced ceramic materials synthesis
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- High-Temperature Coating Behaviors
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Acute Myeloid Leukemia Research
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Cancer-related gene regulation
Hainan University
2025
Inner Mongolia University of Science and Technology
2018-2025
Chinese University of Hong Kong, Shenzhen
2025
University of Alabama at Birmingham
2016-2024
Harbin Institute of Technology
2024
Central South University
2012-2024
Xiangya Hospital Central South University
2012-2024
Huazhong University of Science and Technology
2024
Hubei Cancer Hospital
2010-2024
Shanghai Jiao Tong University
2024
Background— The clinical use of doxorubicin is limited by cardiotoxicity. Histopathological changes include interstitial myocardial fibrosis and the appearance vacuolated cardiomyocytes. Whereas dysregulation autophagy in myocardium has been implicated a variety cardiovascular diseases, role cardiomyopathy remains poorly defined. Methods Results— Most models cardiotoxicity involve intraperitoneal injection high-dose drug, which elicits lethargy, anorexia, weight loss, peritoneal fibrosis,...
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least part, through MAPK pathways. Nevertheless, much remains be learned about the contribution of MAPKs osteoblast vivo. Here we report p38 pathway is required for normal skeletogenesis mice, as mice with deletion any member–encoding genes kinase 3 (Mkk3), Mkk6, p38a, or p38b displayed profoundly reduced mass secondary defective differentiation. Among (MAP3K) family, identified...
Making cardiac cells from fibroblasts Reprogramming noncardiac into functional cardiomyocytes without any genetic manipulation could open up new avenues for regenerative therapies. Cao et al. identified a combination of nine small molecules that epigenetically activate human fibroblasts, efficiently reprogramming them chemically induced (ciCMs). The ciCMs contracted uniformly and resembled cardiomyocytes. This method may be adapted multiple cell types have important implications in medicine....
TGF-beta-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition TAK1 mice by cardiac-specific dominant-negative mutation evokes electrophysiological biochemical properties reminiscent human Wolff-Parkinson-White syndrome, arising from mutations AMP-activated protein kinase (AMPK), most notably, accelerated atrioventricular conduction impaired AMPK activation. To test...
Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) a powerful tool to identify tau-targeted therapeutics. However, such screens have been hampered by heterogeneous neuronal production, high cost low yield, multi-step differentiation procedures. We engineered isogenic iPSC line that harbors inducible neurogenin 2 transgene, transcription...
Reperfusion accounts for a substantial fraction of the myocardial injury occurring with ischemic heart disease. Yet, no standard therapies are available targeting reperfusion injury. Here, we tested hypothesis that suberoylanilide hydroxamic acid (SAHA), histone deacetylase inhibitor approved cancer treatment by US Food and Drug Administration, will blunt injury.Twenty-one rabbits were randomly assigned to 3 groups: (1) vehicle control, (2) SAHA pretreatment (1 day before at surgery), (3)...
Objectives Examine whether osteoarthritis (OA) progression can be delayed by halofuginone in anterior cruciate ligament transection (ACLT) rodent models. Methods 3-month-old male C57BL/6J (wild type; WT) mice and Lewis rats were randomised to sham-operated, ACLT-operated, treated with vehicle, or halofuginone. Articular cartilage degeneration was graded using the Osteoarthritis Research Society International (OARSI)-modified Mankin criteria. Immunostaining, flow cytometry, RT-PCR western...
Abstract Myocardial microRNAs (myo-miRs) are released into the circulation after acute myocardial infarction (AMI). How they impact remote organs is however largely unknown. Here we show that circulating myo-miRs carried in exosomes and mediate functional crosstalk between ischemic heart bone marrow (BM). In mice, find AMI accompanied by an increase levels of myo-miRs, with miR-1, 208, 499 predominantly miR-133 non-exosomal component. Myo-miRs imported selectively to peripheral...
Rho-associated coiled-coil protein kinase 1 (ROCK-1) is a direct cleavage substrate of activated caspase-3, which associated with heart failure. In the course human failure, we found marked ROCK-1 resulting in 130-kDa subspecies, was absent normal hearts and an equivalent cohort patients left ventricular assist devices. Murine cardiomyocytes treated doxorubicin led to enhanced apoptosis, all blocked by caspase-3 inhibitor. addition, bitransgenic mouse model severe cardiomyopathy,...
Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB (IKK)/nuclear factor-kappaB (NF-kappaB) c-Jun N-terminal (JNK)/activator protein (AP-1) activation. Here we report that TNFalpha IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at Lys(158) residue within domain. Tumor receptor-associated factors 2 6 (TRAF2 -6) act as ubiquitin E3 ligases to mediate vivo vitro....
Abstract Mounting evidence suggests that the Hippo coactivator Yes-associated protein 1 (YAP1) is a major mediator of cancer stem cell (CSC) properties, tumor progression, and therapy resistance as well often terminal node many oncogenic pathways. Thus, targeting YAP1 may be novel therapeutic strategy for types tumors with high expression, including esophageal adenocarcinoma. However, effective inhibitors are currently lacking. Here, we identify small molecule (CA3) not only has remarkable...
C urrent therapies targeting pathological ventricular remodeling 1,2 manifest significant effectiveness in reducing morbidity and mortality patients with systolic heart failure (HF). 3However, many instances, disease progression continues unabated.Whereas novel targets are continually being discovered, most innovative do not demonstrate consistent efficacy patients; indeed, prove to be ineffective, even deleterious, before reaching phase III clinical trials.Here, we review therapeutic...
Background: Human induced pluripotent stem cells with normal (wild-type) or upregulated (overexpressed) levels of CCND2 (cyclin D2) expression were differentiated into cardiomyocytes (CCND2 WT CMs OE CMs, respectively) and injected infarcted pig hearts. Methods: Acute myocardial infarction was by a 60-minute occlusion the left anterior descending coronary artery. Immediately after reperfusion, (3×10 7 each) an equivalent volume delivery vehicle around infarct border zone area. Results: The...
High-risk Human papillomaviruses (HPVs) types are associated with more than 90% of premalignant and malignant squamous lesions the uterine cervix. The E6 oncoprotein high-risk HPVs is a key determinant in cell transformation because it induces degradation host pro-apoptotic tumor suppressor p53. recruits intracellular ubiquitin ligase E6AP subsequently proteasome-dependent p53 degradation. Neither nor alone interact p53; however, precise mechanism functional regulation E6/E6AP/p53 complex...