A5054672150- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Calcium signaling and nucleotide metabolism
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Adolescent and Pediatric Healthcare
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Sphingolipid Metabolism and Signaling
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- Ion Channels and Receptors
- Nanoparticle-Based Drug Delivery
- Plant Molecular Biology Research
- Phagocytosis and Immune Regulation
- Marine Bivalve and Aquaculture Studies
- Genomics and Rare Diseases
- Adenosine and Purinergic Signaling
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2025
Peking University Shougang Hospital
2021-2025
Peking University
2017-2025
Tianjin Medical University
2017-2024
The University of Texas Southwestern Medical Center
2024
Huazhong University of Science and Technology
2014-2024
Jiangnan University
2022-2024
Virginia Commonwealth University
2002-2024
Sun Yat-sen University
2020-2024
Abstract Adult hepatic progenitor (oval) cells are facultative stem in liver, which participate a range of human liver diseases, including hepatocellular carcinoma (HCC). However, the molecular pathways regulating expansion and differentiation these poorly understood. We show that active Wnt/β-catenin signaling occurs preferentially within oval cell population, forced expression constitutively β-catenin mutant promotes population regenerated liver. More importantly, we identify subpopulation...
Toll-like receptors (TLRs) are a family of pattern recognition (PRR) with crucial function in innate immune responses. Activation TLR4 signaling at the plasma membrane by lipopolysaccharide (LPS) stimulates proinflammatory pathways dependent on E3 ubiquitin ligase TRAF6. Here we show LPS-induced long non-coding RNA (lncRNA) Mirt2 functions as checkpoint to prevent aberrant activation inflammation, and is potential regulator macrophage polarization. associates with, attenuates Lys63...
Abstract Metachronous liver metastases (MLM) are characterised by high incidence and mortality in clinical colorectal cancer treatment. Currently traditional methods cannot effectively predict prevent the occurrence of metachronous metastasis cancer. Based on 5hmC‐Seal analysis blood tissue samples, this study found that portal venous was more relevant to tumour gDNA than peripheral blood. We performed a novel epigenetic liquid biopsy strategy using 10 5hmC alterations, accurately...
Abstract Recent advances in genome sequencing and functional genomic profiling have promoted many large-scale quantitative trait locus (QTL) studies, which connect genotypes with tissue/cell type-specific cellular functions from transcriptional to post-translational level. However, no comprehensive resource can perform QTL lookup across multiple molecular phenotypes investigate the potential cascade effect of variants. We developed a versatile resource, named QTLbase, for interpreting...
In bacteria, small regulatory non-coding RNAs (sRNAs) are the most abundant class of posttranscriptional regulators.They involved in diverse processes including quorum sensing, stress response, virulence and carbon metabolism.Recent developments high-throughput techniques, such as genomic tiling arrays RNA-Seq, have allowed efficient detection characterization bacterial sRNAs.However, a comprehensive repository to host sRNAs their annotations is not available.Existing databases suffer from...
Activation of the mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NF-κB) cascades after Toll-like receptor (TLR) stimulation contributes to innate immune responses. Signal regulatory (SIRP) α, a member SIRP family that is abundantly expressed in macrophages, has been implicated regulating MAPK NF-κB signaling pathways. In addition, SIRPα can negatively regulate phagocytosis host cells by indicating an inhibitory role immunity. We provide evidences essential endogenous...
Genome-wide association studies have generated over thousands of susceptibility loci for many human complex traits, and yet most these associations the true causal variants remain unknown. Tissue/cell type-specific prediction prioritization non-coding regulatory will facilitate identification underlying pathogenic mechanisms particular diseases traits. By leveraging recent large-scale functional genomics/epigenomics data, we develop an intuitive web server, GWAS4D...
Genome-wide association studies (GWASs) have revolutionized the field of complex trait genetics over past decade, yet for most significant genotype-phenotype associations true causal variants remain unknown. Identifying and interpreting how genetic confer disease susceptibility is still a big challenge. Herein we introduce new database, CAUSALdb, to integrate comprehensive GWAS summary statistics date identify credible sets potential using uniformly processed fine-mapping. The database has...
Abstract Predicting the functional or pathogenic regulatory variants in human non-coding genome facilitates interpretation of disease causation. While numerous prediction methods are available, their performance is inconsistent restricted to specific tasks, which raises demand developing comprehensive integration for those methods. Here, we compile whole base-wise aggregations, regBase, that incorporate largest scores. Building on different assumptions causality, train three composite models...
Abstract Interpreting the molecular mechanism of genomic variations and their causal relationship with diseases/traits are important challenging problems in human genetic study. To provide comprehensive context-specific variant annotations for biologists clinicians, here, by systematically integrating over 4TB genomic/epigenomic profiles frequently-used annotation databases from various biological domains, we develop a database, called VannoPortal. In general, database has following major...
China leads the world in freshwater pearl production, an industry which triangle sail mussel (Sinohyriopsis cumingii) plays a pivotal role. In this paper, we report high-quality chromosome-level genome assembly of S. cumingii with size 2.90 Gb—the largest yet reported among bivalves—and 89.92% anchorage onto 19 linkage groups. The assembled has 37,696 protein-coding genes and 50.86% repeat elements. A comparative genomic analysis revealed expansions 752 gene families, mostly associated...
Objective To compare the electroencephalogram power spectrum of patients with primary insomnia and good sleep controls in multiple brain areas different frequency bands during non-rapid eye movement sleep. Methods 48 insomnias 30 age-and gender-matched were recorded overnight polysomnography. Power spectral analysis was performed six (F3, F4, C3, C4, O1 O2) across seven (delta, sigma, alpha, theta, beta1, beta2, gamma) between controls. Results In insomnias, there significant differences...
AimsRenalase, an enzyme that can metabolize catecholamine, was recently reported to attenuate the ischaemia/reperfusion (I/R)-induced cardiac injury. This work undertaken investigate functions and regulation mechanisms of renalase in protection against I/R
It remains challenging to predict regulatory variants in particular tissues or cell types due highly context-specific gene regulation. By connecting large-scale epigenomic profiles expression quantitative trait loci (eQTLs) a wide range of human tissues/cell types, we identify critical chromatin features that variant potential. We present cepip, joint likelihood framework, for estimating variant's probability context-dependent manner. Our method exhibits significant GWAS signal enrichment...
The aim of this study was to explore the possible mechanisms Ficus carica leaf (FCL) extract in suppressing hepatic gluconeogenesis diabetic mice. Diabetic mice (streptozotocin-induced) received 1 g/kg FCL twice a day for 6 weeks. Fasting blood glucose levels were measured and 2-h oral tolerance test conducted. AMP-activated protein kinase (AMPK), phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase), peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α)...
The transient receptor potential mucolipin 1 (TRPML1) channel has been reported to mediate lysosomal Ca
Despite their central function in tumor immunity, dendritic cells (DCs) can respond to inhibitory signals and become tolerogenic, curtailing T cell responses vivo. Here, we provide the evidence for an of signal regulatory protein (SIRP) α DC survival activation. In tumors from human liver cancer patients, infiltrative DCs expressed elevated levels SIRPα, which is correlated with induction immune tolerance within tumors. Silencing SIRPα resulted a significant increase longevity antigen-pulsed...
Abstract Background Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance expansion in colorectal cancer (CRC) remains poorly characterised. Methods The role COP9 signalosome subunit 6 (CSN6) regulating stemness was evaluated by organoid formation limited dilution analysis. CSN6–TRIM21–OCT1–ALDH1A1 axis vitro vivo. association CSN6, TRIM21 ALDH1A1 expression validated a tissue microarray with 267 CRC...
Corona Virus Disease 2019 (COVID-19) is spreading around the world currently, seriously threatening people's health and global security as an international public emergency. The objective of this study to summarize China's countermeasures experience in response COVID-19 emergence order serve a warning for prevention control, further provide some suggestions fighting COVID-19.Content analysis, expert consultation, high frequency word analysis were applied study. Relevant data information...
Arterial medial calcification (AMC) involves an increased small extracellular vesicle (sEV) secretion and apatite calcium precipitation in the arterial wall. The mechanisms mediating AMC remain poorly understood. In present study, smooth muscle-specific acid ceramidase (Ac) gene knockout mice (Asah1fl/fl/SMCre) were used to demonstrate role of lysosomal ceramide signaling pathway AMC. Asah1fl/fl/SMCre found have more severe both aorta coronary arteries compared their littermates...
The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in podocytes has been implicated the initiation of glomerular inflammation during hyperhomocysteinemia (hHcy). However, mechanism by which NLRP3 products are released from remains unknown. present study tested whether exosome secretion is enhanced NADPH oxidase-produced reactive oxygen species (ROS), may serve as a pathogenic mediating release inflammatory cytokines produced after Hcy...
Red tilapia ( Oreochromis spp .) is one of the most popular fish in China due to its bright red appearance, fast growth rate, and strong adaptability. Understanding sex determination mechanisms vital importance for selection all-male lines increase aquacultural production tilapia. In this research, genetic architecture from four mapping populations n=1 090) was analyzed by quantitative trait loci (QTL)-seq, linkage-based QTL mapping, linkage disequilibrium (LD)-based genome-wide association...