A5018998672- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- CAR-T cell therapy research
- RNA Research and Splicing
- RNA modifications and cancer
- Enzyme Catalysis and Immobilization
- Immune Cell Function and Interaction
- RNA regulation and disease
- MicroRNA in disease regulation
- Nanomaterials for catalytic reactions
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Hedgehog Signaling Pathway Studies
- Ion Channels and Receptors
- Urinary Bladder and Prostate Research
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2025
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2018-2024
Wuhan University
2022-2024
University of Hong Kong
2020-2024
Zhongnan Hospital of Wuhan University
2022-2024
Chinese University of Hong Kong
2022-2024
Taizhou University
2022-2024
Queen Mary Hospital
2023
Immune checkpoint inhibitors (ICI) transformed the treatment landscape of hepatocellular carcinoma (HCC). Unfortunately, patients with attenuated MHC-I expression remain refractory to ICIs, and druggable targets for upregulating are limited. Here, we found that genetic or pharmacologic inhibition fatty acid synthase (FASN) increased levels in HCC cells, promoting antigen presentation stimulating antigen-specific CD8+ T-cell cytotoxicity. Mechanistically, FASN reduced palmitoylation led its...
Abstract Background The burden of common urologic diseases, including benign prostatic hyperplasia (BPH), urinary tract infections (UTI), urolithiasis, bladder cancer, kidney and prostate varies both geographically within specific regions. It is essential to conduct a comprehensive precise assessment the global diseases. Methods We obtained data on incidence, prevalence, mortality, disability-adjusted life-years (DALYs) for aforementioned diseases by age, sex, location, year from Global...
Abstract The ubiquitous second messenger Ca2+ has long been recognized as a key regulator in cell migration. Locally confined Ca2+, particular, is essential for building front-to-rear gradient, which serves to maintain the morphologic polarity required directionally migrating cells. However, little known about source of and mechanism by they crosstalk between different signaling pathways cancer Here, we report that calcium release–activated modulator 2 (ORAI2), poorly characterized...
Abstract Despite the intense CD8+ T-cell infiltration in tumor microenvironment of nasopharyngeal carcinoma, anti-PD-1 immunotherapy shows an unsatisfactory response rate clinical trials, hindered by immunosuppressive signals. To understand how microenvironmental characteristics alter immune homeostasis and limit efficacy here we establish a multi-center single-cell cohort based on public data, containing 357,206 cells from 50 patient samples. We reveal that carcinoma enhance development...
Background and Aims: Deregulation of adenosine-to-inosine editing by adenosine deaminase acting on RNA 1 (ADAR1) leads to tumor-specific transcriptome diversity with prognostic values for HCC. However, ADAR1 editase-dependent mechanisms governing liver cancer stem cell (LCSC) generation maintenance have remained elusive. Approach Results: RNA-seq profiling identified ADAR1-responsive recoding events in HCC showed frequency GLI1 , rather than transcript abundance was clinically relevant....
Objective To compare the electroencephalogram power spectrum of patients with primary insomnia and good sleep controls in multiple brain areas different frequency bands during non-rapid eye movement sleep. Methods 48 insomnias 30 age-and gender-matched were recorded overnight polysomnography. Power spectral analysis was performed six (F3, F4, C3, C4, O1 O2) across seven (delta, sigma, alpha, theta, beta1, beta2, gamma) between controls. Results In insomnias, there significant differences...
Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect itraconazole on Hedgehog (Hh) pathway and proliferation gastric cancer cells. CCK-8 assay colony formation were used to assess effects The expression Hh signaling components in cells treated with was evaluated by reverse-transcription polymerase chain reaction, immunoblotting dual luciferase assay. Tumor xenograft models inhibitory vivo. could remarkably inhibit When...
To evaluate the immunogenicity and safety of COVID-19 vaccine (Vero cell), inactivated, in a population aged ≥60 years with hypertension or(/and) diabetes mellitus.A total 1440 participants were enrolled divided into four groups, 330 group, 300 hypertensive combined group (combined disease group), 480 healthy group. Two doses administered at 21-day interval blood samples collected before vaccination 28 days after second dose to immunogenicity. The adverse events changes pressure glucose...
Cancer-associated fibroblasts (CAFs) play vital roles in establishing a suitable tumor microenvironment. In this study, RNA sequencing data revealed that CAFs could promote cell proliferation, angiogenesis, and ECM reconstitution by binding to integrin families activating PI3K/AKT pathways esophageal squamous carcinoma (ESCC). The secretions of an important role regulating these biological activities. Among secretions, we found MFGE8 is specifically secreted ESCC. Additionally, the protein...
Long non-coding RNAs (lncRNAs) are potential biomarkers of tumors, cardiac disease, and cerebral disease because their interaction with coding RNAs. This work focused on ischemic stroke (IS) aimed to identify novel lncRNA construct lncRNA-related networks in IS.Differentially expressed lncRNAs were identified using Arraystar Human LncRNA Microarray v4.0, validated qRT-PCR. A lncRNA-mRNA co-expression network a lncRNA-miRNA-mRNA regulatory constructed. Functional pathway analyses then...
INTRODUCTION: The full extent of intravenous lidocaine's effectiveness in alleviating postoperative pain and enhancing gastrointestinal function recovery remains uncertain.EVIDENCE ACQUISITION: We conducted an exhaustive search databases to identify randomized controlled trials that compared lidocaine infusion's efficacy a placebo or routine care patients undergoing surgery. primary outcome measure was resting scores 24 h postoperatively. utilized random-effects model based on the...
Background: Previous observational studies have reported a bidirectional association between periodontitis and type 2 diabetes, but the causality of these relationships remains unestablished. We clarified causal through two-sample Mendelian randomization (MR). Methods: obtained summary-level data for diabetes from several published large-scale genome-wide (GWAS) individuals European ancestry. For casual effect on we used five independent single-nucleotide polymorphisms (SNPs) specific to...