A5102849513- Spectroscopy and Chemometric Analyses
- Laser-induced spectroscopy and plasma
- Epigenetics and DNA Methylation
- Geological and Geochemical Analysis
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- earthquake and tectonic studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Water Quality Monitoring and Analysis
- Birth, Development, and Health
- Plant Diversity and Evolution
- Geochemistry and Geologic Mapping
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Genetic diversity and population structure
- High-pressure geophysics and materials
- Cancer-related molecular mechanisms research
- Retinal Imaging and Analysis
- Pulmonary Hypertension Research and Treatments
- Fermentation and Sensory Analysis
- Meat and Animal Product Quality
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
Anhui Medical University
2024-2025
Chinese Academy of Sciences
2019-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Hebei Normal University
2022-2025
Institute of Technology of Cambodia
2025
Xiamen University
2025
Hebei University of Technology
2025
Shanghai Maritime University
2025
117th Hospital of People's Liberation Army
2025
Huainan Normal University
2023-2024
Acute lung injury (ALI) is characterized by pulmonary diffusion abnormalities that may progress to multiple-organ failure in severe cases. There are limited effective treatments for ALI, which makes the search new therapeutic avenues critically important. Macrophages play a pivotal role pathogenesis of ALI. The degree macrophage polarization closely related severity and prognosis S100A9 promotes M1 macrophages. present study assessed effects S100A9-gene deficiency on acute injury. Our cohort...
Abstract Evolutionary radiation is a widely recognized mode of species diversification, but its underlying mechanisms have not been unambiguously resolved for species-rich cosmopolitan plant genera. In particular, it remains largely unknown how biological and environmental factors jointly driven occurrence in specific regions. Here, we use Rhododendron, the largest genus woody plants Northern Hemisphere, to investigate geographic climatic factors, as well functional traits, worked together...
Diabetic retinopathy (DR) is the leading cause of blindness among working-age population. Although controlling blood glucose levels effectively reduces incidence and development DR to less than 50%, there are currently no diagnostic biomarkers or effective treatments for in glucose-well-controlled diabetic patients (GW-DR). In this study, we established a prospective GW-DR cohort by strictly adhering glycemic control guidelines maintaining regular retinal examinations over median 2-year...
Germline stem cells play an essential role in establishing the fertility of organism. Although extensively characterized, regulatory mechanisms that govern fundamental properties mammalian female germline remain poorly understood. We generate genome-wide profiles histone modifications H3K4me1, H3K27ac, H3K4me3, and H3K27me3, DNA methylation, RNA polymerase II occupancy perform transcriptome analysis mouse cells. Comparison enhancer regions between embryonic identifies lineage-specific...
Fast detection of heavy metals in plant materials is crucial for environmental remediation and ensuring food safety. However, most contain high moisture content, the influence which cannot be simply ignored. Hence, we proposed reducing method fast using laser-induced breakdown spectroscopy (LIBS). First, investigated effect content on signal intensity, stability, plasma parameters (temperature electron density) determined main influential factors (experimental F change analyte concentration)...
Abstract Background Gymnosperms represent five of the six lineages seed plants. However, most sequenced plant mitochondrial genomes (mitogenomes) have been generated for angiosperms, whereas mitogenomic sequences only gymnosperms. In particular, complete mitogenomes are available all major except Conifer II (non-Pinaceae conifers or Cupressophyta), an important lineage including families, which impedes a comprehensive understanding diversity and evolution in Results Here, we report...
Metastasis is the primary cause of cancer-related deaths, and colorectal cancer (CRC) liver metastasis a major poor prognostic factor in CRC. NAT1 (N-acetyltransferase 1) plays crucial role invasive metastatic processes cancer. The molecular mechanism on tumor cells were verified by establishing cell model overexpression knockdown NAT1, further for animal experiments. In vivo vitro experiments have demonstrated that reduces ability invasion cells. inhibits PI3K/AKT/mTOR signaling pathway,...
Abstract Ubiquitin A‐52 residue ribosomal protein fusion product 1 (UBA52) has a role in the occurrence and development of tumours. However, mechanism by which UBA52 regulates hepatocellular carcinoma (HCC) tumorigenesis progression remains poorly understood. By using Cell Counting Kit (CCK‐8), colony formation, wound healing Transwell assays, we assessed effects knockdown overexpression on proliferation migration HCC cells vitro. establishing subcutaneous metastatic tumour models nude mice,...
Pulmonary artery endothelial plexiform lesion is responsible for pulmonary vascular remodeling (PVR), a basic pathological change of arterial hypertension (PAH). Recent evidence suggests that epoxyeicosatrienoic acid (EET), which derived from arachidonic by cytochrome p450 (CYP) epoxygenase, has an essential role in PAH. However, until now, most research focused on vasoconstriction; it unclear whether EET produces mitogenic and angiogenic effects cells (PAEC). Here we found 500 nM/l 8,9-EET,...
Abstract Tobacco mosaic virus (TMV) is one of the most devastating viruses to crops, which can cause severe production loss and affect quality products. In this study, we have proposed a novel approach discriminate TMV-infected tobacco based on laser-induced breakdown spectroscopy (LIBS). Two different kinds samples (fresh leaves dried leaf pellets) were collected for spectral acquisition, partial least squared discrimination analysis (PLS-DA) was used establish classification models full...
Abstract Background Mitochondrial gene transfer/loss is common in land plants, and therefore the fate of missing mitochondrial genes has attracted more attention. The content gymnosperm mitochondria varies greatly, supplying a system for studying evolutionary genes. Results Here, we studied tempo pattern gymnosperms represented by all 13 families, using high-throughput sequencing both DNA cDNA. All 41 protein-coding were found cycads, Ginkgo Pinaceae, whereas multiple absent Conifer II...
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by a novel bunyavirus that poses significant threat to human health. The aim of this study was identify precise and user‐friendly indicator for predicting the mortality patients SFTS. We retrospectively analyzed data from 181 hospitalized Inflammatory markers, including neutrophil‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte (LMR), platelet‐to‐lymphocyte (PLR), systemic inflammation index (SII),...
SUMMARY Clathrin‐mediated endocytosis (CME) plays a key role in the internalization of plasma membrane‐localized proteins, lipids and extracellular substances; however, regulatory mechanism CME plants is unclear. In this work, we demonstrated that molecular chaperon HSP70‐9 required for Arabidopsis thaliana . Knocking out gene led to auxin‐related phenotypes accumulation auxin efflux carrier PINs root cells, indicating involved PIN trafficking process. Immunolocalization studies showed was...
Algal blooms pose a significant threat to global environmental health, compromising water quality and public safety. Ultrasonic radiation has emerged as promising, eco-friendly strategy for controlling these blooms, but the underlying mechanisms remain unclearly understood. This study investigated effects of ultrasonic on growth, photosynthetic performance, antioxidant defense systems an algal mixture over 5-day period. Analysis techniques, including scanning electron microscopy (SEM),...
Growing imperative for intelligent transformation of electro-ionic actuators in soft robotics has necessitated self-perception accurately mapping their nonlinear dynamic responses. Despite the promise integrating crack-based strain sensors such a purpose, significant challenges remain controlling crack propagation to prevent induction through-cracks, resulting lower sensitivity, linearity, and poor detection limits. Herein, we propose hierarchical synergistic enhancement structure by...
Using PPI (protein-protein interaction) networks to predict protein function is a major research directions in genomics. However, due the complexity and diversity of functions, traditional prediction methods using often yield unsatisfactory results. To enhance accuracy predicting novel algorithm based on interactions was proposed this paper, which combined graph metathesis with semantic similarity methods, utilized FunCat's hierarchical similarity. The model validated Saccharomyces...
Triple-negative breast cancer (TNBC) is a highly malignant tumor that requires effective therapeutic targets and drugs. Oxidative phosphorylation (OXPHOS) metabolic vulnerability of TNBC, but the molecular mechanism responsible for enhanced OXPHOS remains unclear. The current strategies target electronic transfer function cannot distinguish cells from normal cells. Investigating underlying regulation developing corresponding therapy TNBC great significance. Immunohistochemistry sequencing...
It is important to establish a coronary heart disease (CHD) prediction model with high efficiency and precision for early diagnosis of CHD using clinical information. While existing deep learning-based models possess the limitations large datasets long training time, machine have low accuracy robustness, which are unsuitable application. This study aimed design fast high-precision intelligent information predict CHD. Five public datasets, including 303, 293, 200, 123 patients 55, 14, 14...
Summary To develop simple, cheap and convenient sensors for Yao ‐meat freshness evaluation biogenic amines ( BA s) detection, a colorimetric sensor array was made by printing nine natural pigments on hydrophobic nanoporous film. A colour change profile each sample obtained differentiating the image of before after exposure to volatile organic compounds (VOCs). The exposed atmospheres containing s vapours with concentrations over range 10–30 ppm. Rosa chinensis extract possessed highest...