Hongyan Zhu

ORCID: 0000-0002-3395-2222
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About
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Research Areas
  • Neuroscience and Neuropharmacology Research
  • Spectroscopy and Chemometric Analyses
  • Functional Brain Connectivity Studies
  • Pain Mechanisms and Treatments
  • Target Tracking and Data Fusion in Sensor Networks
  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • Gastrointestinal motility and disorders
  • Advanced Measurement and Detection Methods
  • Advanced Neuroimaging Techniques and Applications
  • Ion channel regulation and function
  • Pancreatitis Pathology and Treatment
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuropeptides and Animal Physiology
  • Advanced MRI Techniques and Applications
  • Nerve injury and regeneration
  • Cancer Immunotherapy and Biomarkers
  • Advanced Combustion Engine Technologies
  • Spinal Cord Injury Research
  • Genetics and Neurodevelopmental Disorders
  • Smart Agriculture and AI
  • Epilepsy research and treatment
  • Remote Sensing in Agriculture
  • Sirtuins and Resveratrol in Medicine
  • Adipose Tissue and Metabolism

Xi'an Jiaotong University
2003-2025

Pudong Medical Center
2024

Fudan University
2024

Guangxi Normal University
2020-2024

State Key Laboratory of Medical Neurobiology
2024

Shanghai University
2010-2024

Chinese PLA General Hospital
2022-2024

First People's Hospital of Yunnan Province
2024

Kunming University of Science and Technology
2024

West China Hospital of Sichuan University
2014-2023

We investigated the feasibility and potentiality of presymptomatic detection tobacco disease using hyperspectral imaging, combined with variable selection method machine-learning classifiers. Images from healthy TMV-infected leaves 2, 4, 6 days post infection were acquired by a pushbroom reflectance imaging system covering spectral range 380-1023 nm. Successive projections algorithm was evaluated for effective wavelengths (EWs) selection. Four texture features, including contrast,...

10.1038/s41598-017-04501-2 article EN cc-by Scientific Reports 2017-06-19

Aging is a complex process in which the structure and function of various tissues organs gradually decline with age, ovarian aging affects reproductive capacity females induces age-related diseases. Resveratrol, natural polyphenol compound, extends life span has protective effect on ovaries vertebrates. However, effects underlying mechanisms resveratrol delaying are unclear. In this study, using an annual fish Nothobranchius guentheri, we demonstrated that...

10.1093/gerona/glad009 article EN The Journals of Gerontology Series A 2023-01-11

Remote estimation of flower number in oilseed rape under different nitrogen (N) treatments is imperative precision agriculture and field remote sensing, which can help to predict the yield rape. In this study, an unmanned aerial vehicle (UAV) equipped with Red Green Blue (RGB) multispectral cameras was used acquire a series images at flowering stage, manually counted as reference. Images were first classified using K-means method based on Commission Internationale de l’Éclairage (CIE) L*a*b*...

10.3390/rs10091484 article EN cc-by Remote Sensing 2018-09-17

Background Tertiary lymphoid structures (TLSs) are crucial in promoting and maintaining positive anti-tumor immune responses. The tumor stroma has a powerful immunosuppressive function that could exclude tumor-infiltrating lymphocytes from the beds lead to “cold” phenotype. TLSs percentage (TSP) significantly associated with prognosis of patients certain cancers. However, exact roles TSP their intrinsic relationship still largely unknown colorectal cancer (CRC). Methods were assessed using...

10.3389/fimmu.2022.962056 article EN cc-by Frontiers in Immunology 2022-09-16

Abstract Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts prognosis of colorectal cancer patients. However, potential impact TLS in shaping status rectal adenocarcinoma, intrinsic relationship between neoadjuvant therapies (neoTx) remain unclear. We performed hematoxylin-eosin staining, immunohistochemical biomolecular analyses investigate tumor-infiltrating lymphocytes (TILs) 221 neoTx-treated 242 treatment-naïve locally advanced (LARC) High...

10.1038/s41698-024-00533-w article EN cc-by npj Precision Oncology 2024-03-02

We investigated the feasibility and potentiality of determining firmness, soluble solids content (SSC), pH in kiwifruits using hyperspectral imaging, combined with variable selection methods calibration models. The images were acquired by a push-broom reflectance imaging system covering two spectral ranges. Weighted regression coefficients (BW), successive projections algorithm (SPA) genetic algorithm-partial least square (GAPLS) compared evaluated for effective wavelengths. Moreover,...

10.1038/s41598-017-08509-6 article EN cc-by Scientific Reports 2017-08-04

Near-infrared (874-1734 nm) hyperspectral imaging (NIR-HSI) technique combined with chemometric methods was used to trace origins of 1200 Chinese wolfberry samples, which from Ningxia, Inner Mongolia, Sinkiang and Qinghai in China. Two approaches, named pixel-wise object-wise, were investigated discriminative the origin these wolfberries. The classification assigned a class each pixel individual wolfberries, this approach, differences wolfberries four reflected intuitively. Object-wise...

10.1371/journal.pone.0180534 article EN cc-by PLoS ONE 2017-07-13

The directional organization of multiple nociceptive regions, particularly within obscure operculoinsular areas, underlying multidimensional pain processing remains elusive. This study aims to establish the fundamental between somatosensory and insular cortices in routing information. By employing an integrated multimodal approach high-field fMRI, intracranial electrophysiology, transsynaptic viral tracing rats, we observed a hierarchically organized connection S1/S2 → posterior insula...

10.1016/j.neuroimage.2024.120549 article EN cc-by-nc-nd NeuroImage 2024-02-20

Nuclear factor-kappa B (NF-κB) signaling is implicated in both cancer development and inflammation processes. However, the roles mechanisms of NF-κB cancer-induced pain (CIP) remain unknown. This study was designed to investigate p65 subunit regulation purinergic receptor (P2X3R) plasticity dorsal root ganglion (DRG) CIP rats. We showed here that tumor cell injection produced mechanical thermal hyperalgesia, an enhanced body weight-bearing difference, which correlated with upregulation P2X3R...

10.1097/j.pain.0000000000000248 article EN Pain 2015-06-04

The neuroimaging literature provides compelling evidence for functional dysconnectivity in people with psychosis. However, it is likely that at least some of the observed alterations represent secondary effects illness chronicity and/or antipsychotic medication. In addition, extent to which these are specific psychosis or a transdiagnostic feature psychiatric remains unclear. aim this study was therefore examine diagnostic specificity drug-naïve first-episode (FEP). We used resting-state...

10.1038/npp.2016.247 article EN cc-by-nc-nd Neuropsychopharmacology 2016-10-26

Abstract Tobacco mosaic virus (TMV) is one of the most devastating viruses to crops, which can cause severe production loss and affect quality products. In this study, we have proposed a novel approach discriminate TMV-infected tobacco based on laser-induced breakdown spectroscopy (LIBS). Two different kinds samples (fresh leaves dried leaf pellets) were collected for spectral acquisition, partial least squared discrimination analysis (PLS-DA) was used establish classification models full...

10.1038/srep44551 article EN cc-by Scientific Reports 2017-03-16

Purpose To use diffusion-tensor (DT) imaging and graph theory approaches to explore the brain structural connectome in pediatric posttraumatic stress disorder (PTSD). Materials Methods This study was approved by relevant research ethics committee, all participants' parents or guardians provided informed consent. Twenty-four patients with PTSD 23 control subjects exposed trauma but without were recruited after 2008 Sichuan earthquake. The constructed using DT tractography thresholding mean...

10.1148/radiol.2016160907 article EN Radiology 2016-10-25

Abstract: Melatonin not only plays a major role in the regulation of circadian rhythms, but is also involved antioxidative defense and immunomodulation. Circulating melatonin levels are derived primarily from pineal gland while other sources have been reported. Here, we show for first time that astrocytes rat cortex glioma C6 cell line synthesize vitro. In addition, presence serotonin, precursor two key enzymes pathway synthesis, i.e. N ‐acetyltransferase hydroxyndole‐ O ‐methyltransferase...

10.1111/j.1600-079x.2007.00466.x article EN Journal of Pineal Research 2007-06-02

The use of local agents to achieve hemostasis bone that does not interfere with repair and recovery is a complex emergency subject in surgery. In this study, the dual functional biodegradable self-assembling nanopeptide (SAP) RADA16-I was synthesized by solid phase synthesis shown exhibit immediate accelerative osteosis. showed good performance as hemostatic agent, which investigated comparison effects wax ilium defect model New Zealand rabbits. exhibited efficient function regeneration both...

10.1021/acs.biomac.5b00493 article EN Biomacromolecules 2015-09-08

Accurate categorization and timely control of leaf diseases are crucial for citrus growth. We proposed the Multi-Models Fusion Network (MMFN) detection based on model fusion transfer learning. Compared to traditional methods, algorithm (integrating learning Alexnet, VGG, Resnet) we can address issues limited categories, slow processing speed, low recognition accuracy. By constructing efficient deep models training optimizing them with a large dataset images, ensured broad applicability...

10.3390/agriculture14091549 article EN cc-by Agriculture 2024-09-07

Traditional maneuvering target-tracking(MTT) algorithms typically require predefined mathematical motion models to simulate the target's motion. Due difficulty in precisely predicting model of target practice, traditional often suffer from tracking delays and large trajectory errors. Data-driven deep learning methods do not rely on models, bringing new ideas MTT. However, these lack ability generalize randomness To address this issue, a Variational LSTM based MTT algorithm VlstmMTT is...

10.1049/icp.2024.2892 article EN IET conference proceedings. 2025-01-01

To assess whether Treg/Th17 balance was broken in patients with idiopathic dilated cardiomyopathy (DCM). We studied 25 who were diagnosed as DCM (18 men and seven women, mean age 35.6 +/- 5.2) normal persons 33.8 4.9). Then, we detected functions on different levels including cell frequencies, related cytokine secretion key transcription factors controls. The results demonstrated that revealed significant increase peripheral Th17 number, Th17-related cytokines (IL-17, IL-6, IL-23) factor...

10.1111/j.1365-3083.2010.02374.x article EN Scandinavian Journal of Immunology 2010-01-20
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