A5037730841- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Acupuncture Treatment Research Studies
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Traditional Chinese Medicine Studies
- Complementary and Alternative Medicine Studies
- Memory and Neural Mechanisms
- COVID-19 and Mental Health
- Resilience and Mental Health
- Health, Environment, Cognitive Aging
- Heart Rate Variability and Autonomic Control
- Attention Deficit Hyperactivity Disorder
- Neurogenetic and Muscular Disorders Research
- Optimism, Hope, and Well-being
- Gastrointestinal motility and disorders
- Grit, Self-Efficacy, and Motivation
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Chongqing University
2022
King's College London
2016-2018
University of Liverpool
2018
Public Health Clinical Center of Chengdu
2018
Abstract Children exposed to natural disasters are vulnerable the development of posttraumatic stress disorder (PTSD). Recent studies other neuropsychiatric disorders have used graph‐based theoretical analysis investigate topological properties functional brain connectome. However, little is known about this connectome in pediatric PTSD. Twenty‐eight PTSD patients and 26 trauma‐exposed non‐PTSD were recruited from 4,200 screened subjects after 2008 Sichuan earthquake undergo a resting‐state...
Abstract Although functional and structural abnormalities in brain regions involved the neurobiology of fear anxiety have been observed patients with social disorder (SAD), findings heterogeneous due to small sample sizes, demographic confounders, methodological differences. Besides, multimodal neuroimaging studies on structural-functional deficits couplings are rather scarce. Herein, we aimed explore network anomalies effects structure-function SAD diagnosis. High-resolution magnetic...
Abstract INTRODUCTION Subjective cognitive decline (SCD) is increasingly recognized as closely related to future Alzheimer's disease (AD). Numerous neuroimaging findings in SCD are inconsistent. We tested whether the various localize a common brain network. METHODS Using novel coordinate network mapping approach, we delineated damage networks that were functionally connected reported findings. then decoded these using microscale transcriptomic and chemo‐architectures psychological processes....
Purpose To use resting-state functional magnetic resonance (MR) imaging and graph theory approaches to investigate the brain connectome its potential relation disease severity in Parkinson (PD). Materials Methods This case-control study was approved by local research ethics committee, all participants provided informed consent. There were 153 right-handed patients with PD 81 healthy control recruited who matched for age, sex, handedness undergo a 3-T MR examination. The whole-brain...
As characterized by repeated exposure of others' trauma, vicarious traumatization is a common negative psychological reaction during the COVID-19 pandemic and plays crucial role in development general mental distress. This study aims to identify functional connectome that encodes individual variations pandemic-related reveal underlying brain-vicarious mechanism predicting The eligible subjects were 105 university students (60 females, aged from 19 27 years) undergoing brain MRI scanning...
Abstract Vicarious traumatization (VT), a negative reaction to witnessing others’ trauma, has been experienced by some people during the COVID-19 pandemic, and can lead mental health problems. This study aimed identify functional brain markers of COVID-specific VT explore psychological mechanism underlying brain-VT link. One hundred healthy participants underwent resting-state magnetic resonance imaging before pandemic (October 2019–January 2020) completed measurement (February–April 2020)....
Studies of posttraumatic stress disorder (PTSD) are complicated by wide variability in the intensity and duration prior stressors patient participants, secondary effects chronic psychiatric illness, a variable history treatment with medications. In magnetic resonance imaging (MRI) studies, samples have often been small, they were not compared to similarly stressed patients without PTSD order control for general effects. Findings from these studies inconsistent. The present study investigated...
Purpose To use diffusion-tensor (DT) imaging and graph theory approaches to explore the brain structural connectome in pediatric posttraumatic stress disorder (PTSD). Materials Methods This study was approved by relevant research ethics committee, all participants' parents or guardians provided informed consent. Twenty-four patients with PTSD 23 control subjects exposed trauma but without were recruited after 2008 Sichuan earthquake. The constructed using DT tractography thresholding mean...
As a hot research topic in the field of psychology and psychiatry, trait optimism reflects tendency to expect positive outcomes future. Consistent evidence has demonstrated role reducing anxiety among different populations. However, less is known about neural bases underlying mechanisms for how protects against healthy brain. In this investigation, we examined these issues 231 adolescent students by assessing resting-state brain activity (i.e., fractional amplitude low-frequency...
The COVID-19 pandemic has caused some individuals to experience vicarious traumatization (VT), an adverse psychological reaction those who are primarily traumatized, which may negatively impact one's mental health and well-being been demonstrated vary with personal trauma history. neural mechanism of VT how past history affects current remain largely unknown. This study aimed identify neurobiological markers that track individual differences in reveal the link between childhood cumulative (CCT) VT.
Aims: This study aimed to explore the relationship between growth mindset and job satisfaction among Chinese nurses, examine underlying mediating role of grit self‐efficacy in this relationship. Background: As a long‐standing research topic nursing management, plays an essential patient care, healthcare organizations, nurses’ career planning development. Therefore, it is extremely important psychosocial factors that contribute satisfaction. Design: A descriptive, cross‐sectional survey...
Subthreshold depression (SD) is common in the older population, more so females than males, and can lead to serious physical mental ill-health. However, underlying neurobiology remains unclear. This study used multimodal magnetic resonance imaging (MRI) investigate topological organization coupling of structural functional brain networks women with SD. We constructed network from diffusion MRI resting-state 50 SD 52 demographically-matched healthy controls (HC). graph theory analysis examine...
Patients with Parkinson's disease mild cognitive impairment (PD-M) progress to dementia more frequently than those normal cognition (PD-N), but the underlying neurobiology remains unclear. This study aimed define specific morphological brain network alterations in PD-M, and explore their potential diagnostic value. Twenty-four PD-M patients, 17 PD-N 29 healthy controls (HC) underwent a structural MRI scan. Similarity between interregional gray matter volume distributions was used construct...
This study used resting-state functional MRI (r-fMRI) to evaluate intrinsic brain activity in drug-naive patients with essential tremor (ET) and without head tremor. We enrolled 20 ET hand (h-ET), 27 (a-ET), healthy controls (HCs). All participants underwent r-fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) blood oxygen level-dependent signals was characterize regional cerebral function. identified increased ALFF value the bilateral posterior lobe cerebellum...
Abstract Mild cognitive impairment (MCI), a well‐defined nonmotor manifestation of Parkinson's disease (PD), greatly impairs functioning and quality life. However, the contribution cerebral perfusion, quantified by arterial spin labeling (ASL), to MCI in PD remains poorly understood. The selection an optimal delay time is difficult for single‐delay ASL, problem which avoided multidelay ASL. This study uses multiparametric ASL investigate perfusion including blood flow (CBF) transit (ATT)...
Disrupted topological organization of brain functional networks has been widely observed in posttraumatic stress disorder (PTSD). However, the grey matter (GM) network not yet investigated pediatric PTSD who was more vulnerable to develop when exposed stress. Twenty two patients and 22 matched trauma-exposed controls survived a massive earthquake (8.0 magnitude on Richter scale) Sichuan Province western China 2008 underwent structural imaging with MRI 8–15 months after earthquake. Brain were...
Abstract This study explores the topological properties of brain gray matter (GM) networks in patients with paroxysmal kinesigenic dyskinesia (PKD) and asks whether GM network features have potential diagnostic value. We used 3D T1‐weighted magnetic resonance imaging graph theoretical approaches to investigate organization morphological 87 PKD 115 age‐ sex‐matched healthy controls. applied a support vector machine matrices classify versus Compared HC group, showed significant abnormalities...