A5057347003- Polyamine Metabolism and Applications
- Sulfur Compounds in Biology
- Nitric Oxide and Endothelin Effects
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Functional Brain Connectivity Studies
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neuropharmacology Research
- Gastric Cancer Management and Outcomes
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Cognitive and developmental aspects of mathematical skills
- Neuroscience of respiration and sleep
- Cardiac Ischemia and Reperfusion
- Mental Health Research Topics
- Optimism, Hope, and Well-being
- Mitochondrial Function and Pathology
- Mathematics Education and Teaching Techniques
- Heart Rate Variability and Autonomic Control
- Circular RNAs in diseases
- Grit, Self-Efficacy, and Motivation
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Animal Ecology and Behavior Studies
- Visual perception and processing mechanisms
Institute of High Energy Physics
2025
Institute of Physics
2025
Chinese Academy of Sciences
2025
Southwest Minzu University
2015-2024
Harbin Medical University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Zhongshan Hospital
2023-2024
Sun Yat-sen University
2023-2024
Shanghai Medical College of Fudan University
2024
Wuyi University
2024
A proof of principle the first rationally designed, chemically powered, molecular-scale motor is described. The thermodynamic considerations leading to choice 6a and 7a as initial prototypes are provided, synthesis separation them from their atropisomers detailed. phosgene-powered unidirectional rotation its rotamer 6b demonstrated. It further established that shortening length tether (→7a) changes rate-limiting step accelerates speed rotation.
Building on prototype 1, which achieves 120° of phosgene-powered unidirectional rotation to rotamer 6 (see Figure 5 in the full article), 7 was designed accomplish repeated Scheme 7). Compound contains an amino group each blade triptycene and a 4-(dimethylamino)pyridine (DMAP) unit selectively deliver phosgene (or its equivalent) amine "firing position". The synthesis is described: key constructive steps are benzyne addition anthracene generate triptycene, stilbene photocyclization construct...
This study sought to validate the Short Grit Scale (Grit-S), an instrument that measures perseverance and passion for long-term goals, among Chinese high school students. Confirmatory factor analyses revealed scale retains two-factor structure of original scale. The demonstrated satisfactory internal consistency test–retest reliability. Evidence construct validity was found in relation Big Five personality traits, self-control, IQ. criterion via observation grit explained unique variance...
Chinese adolescents encounter a lot of stressors, such as academic burden and parental pressure. However, little is known about their perception stress. The 10-item Perceived Stress Scale (PSS-10) widely used instrument to measure individuals' appraisal global stress in research clinical practice. current study aimed evaluate the best-fit factor structure model PSS-10 measurement invariance across genders adolescents.A total 1,574 senior high school students completed (mean age = 15.26 ±...
Abstract Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of immunosuppressive makes it very difficult to accurately predict clinical outcomes based only on a single molecule. Here, we establish comprehensive immune scoring system (ISS GC ) 6 ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using LASSO method improve accuracy provide an additional selection strategy for adjuvant chemotherapy gastric...
Polyamines have been shown to delay cellular and organismal aging provide cardiovascular protection in humans.Because age-related dysfunction is often accompanied by impaired mitochondrial biogenesis function, we explored the ability of spermidine (SPD), a major mammalian polyamine, attenuate cardiac through activation biogenesis.Cardiac polyamine levels were reduced aged (24-month-old) rats.Six-week SPD supplementation restored content, preserved myocardial ultrastructure, inhibited...
Abstract Background BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance human gastric cancer (GC) are elusive. Methods We obtained GC tissues corresponding normal from 8 patients identified BATF2 a downregulated gene via RNA-seq. qRT-PCR western blotting were applied to examine levels tissues. The value of was elucidated using tissue microarray IHC analyses two independent cohorts. functional roles...
Abstract Post-Partum Depression (PPD) is the most common health issue impacting emotional well being in women and often comorbid with anxiety (PPD-A). Previous studies have shown that adequate social support can protect against PPD PPD-A. However, how brain connectome disrupted PPD-A neural basis underlying role of remains unclear. The present study aims to explore these issues patients Well-established questionnaires resting-state functional Magnetic Resonance Imaging (rsfMRI) were...
Abstract Background Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D 2 receptors are expressed in cardiac tissues. However, roles dopamine myocardial cardiomyocyte apoptosis unclear. Here we investigated effects both agonist (bromocriptine) antagonist (haloperidol) on cultured neonatal rat ventricular myocytes induced by injury. Methods was simulated incubating primarily cardiomyocytes ischemic (hypoxic) buffer...
Lipid catabolism disorder is the primary cause of atherosclerosis. Transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy to promote lipid degradation. Hypericin-mediated sonodynamic therapy (HY-SDT) has been proved non-invasively inducing THP-1-derived apoptosis; however, it unknown whether could be triggered HY-SDT influence cellular via regulating TFEB. Here, we report that resulted in time-dependent activation through AMPK/AKT/mTOR pathway. Besides,...
Background/Aim: Autophagy plays an important role in cellular homeostasis through the disposal and recycling of components. Hydrogen sulphide (H2S) is third endogenous gas that has been shown to confer cardiac protective effects. Given regulation autophagy cardioprotection, this study aimed investigate effects H2S via during high glucose treatment. Methods: This investigated content plasma as well myocardial, ultrastructural changes mitochondria autophagosomes. also apoptotic rate using...
Abstract There has been increasing interest in identifying factors to predict subjective well-being the emerging field of positive psychology over past two decades. Dispositional hope, which reflects one’s goal-directed tendencies, including both pathway thinking (planning meet goals) and agency (goal-directed determination), emerged as a stable predictor for well-being. However, neurobiological substrates dispositional hope brain-hope mechanism predicting remain unclear. Here, we examined...
Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor (CaSR) expression. Spermine, direct agonist CaSR, was found deficient in cardiomyocytes T1D rats. However, the role spermine unclear. Here, we examined cardioprotective effect exogenous on streptozotocin (STZ) induced-T1D rats high-glucose...
<h3>Importance</h3> Gastric neuroendocrine carcinoma and mixed adenoneuroendocrine are rare pathological types of gastric cancer, there is a lack multicenter studies comparing the prognosis recurrence patterns carcinoma, adenocarcinoma. <h3>Objective</h3> To compare differences in long-term survival among <h3>Design, Setting, Participants</h3> This cohort study included patients with resectable at 23 hospitals China from January 2006 to December 2016. In addition, adenocarcinoma were...
Abstract Vicarious traumatization (VT), a negative reaction to witnessing others’ trauma, has been experienced by some people during the COVID-19 pandemic, and can lead mental health problems. This study aimed identify functional brain markers of COVID-specific VT explore psychological mechanism underlying brain-VT link. One hundred healthy participants underwent resting-state magnetic resonance imaging before pandemic (October 2019–January 2020) completed measurement (February–April 2020)....
Excessive ROS accumulation contributes to cardiac injury in type 2 diabetes mellitus. Hydrogen sulfide (H2S) is a vital endogenous gasotransmitter alleviate damage diabetic cardiomyopathy (DCM). However, the underlying mechanisms remain unclear. In this study, we investigated effects of NaHS administration db/db mice via intraperitoneal injection for 20 weeks and treatment high glucose (HG), palmitate (PA) HL-1 cardiomyocytes 48 h, respectively. H2S levels were decreased hearts exposed HG...
Endothelial cell dysfunction is one of the main reasons for type II diabetes vascular complications. Hydrogen sulphide (H2 S) has antioxidative effect, but its regulation on mitochondrial dynamics and mitophagy in aortic endothelial cells under hyperglycaemia hyperlipidaemia unclear. Rat (RAECs) were treated with 40 mM glucose 200 μM palmitate to imitate endothelium hyperlipidaemia, 100 NaHS was used as an exogenous H2 S donor. Firstly, we demonstrated that high decreased production CSE...
The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation cardiovascular functions have been recognized. Cystathionine gamma-lyase (CSE) is a major H2S-producing enzyme system. Ischemic post-conditioning (PC) provides cadioprotection young hearts but lost aging hearts. involvement H2S recovery PC-induced cardioprotection unclear. In present study, we demonstrated that ischemia/reperfusion (I/R) decreased production rate CSE expression, aggravated cardiomyocytes...
Background: Oxidative stress inducing hyperglycemia and high glucose play an important role in the development of cardiac fibrosis associated with diabetic cardiomyopathy. The endogenous gasotransmitter hydrogen sulfide (H2S) can act a cytoprotective manner. However, whether H2S could inhibit fibrotic process is unclear. purpose our study was to examine underlying mechanisms behind Methods: Diabetic cardiomyopathy induced rats by injection streptozotocin (STZ). Cardiac proliferation rat...