A5017366969- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Nitric Oxide and Endothelin Effects
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Cerebral Palsy and Movement Disorders
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Ion channel regulation and function
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- RNA modifications and cancer
- MRI in cancer diagnosis
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Microfluidic and Bio-sensing Technologies
- Cardiac Ischemia and Reperfusion
- Infant Development and Preterm Care
- Monoclonal and Polyclonal Antibodies Research
Jiamusi University
2010-2025
Central South University
2025
Xiangya Hospital Central South University
2025
Hunan Provincial Center for Disease Control and Prevention
2025
Nanjing University of Posts and Telecommunications
2024
Lanzhou University
2024
Hohhot First Hospital
2024
Beijing Red Cross Blood Center
2020-2024
Sun Yat-sen University
2017-2023
Sun Yat-sen University Cancer Center
2017-2023
Abstract Background Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D 2 receptors are expressed in cardiac tissues. However, roles dopamine myocardial cardiomyocyte apoptosis unclear. Here we investigated effects both agonist (bromocriptine) antagonist (haloperidol) on cultured neonatal rat ventricular myocytes induced by injury. Methods was simulated incubating primarily cardiomyocytes ischemic (hypoxic) buffer...
Osteosarcoma (OS) is a common primary bone malignancy. Long noncoding RNA HCG18 known to play an important role in variety of cancers. However, its OS and relevant molecular mechanisms are unclear.Real-time quantitative PCR was performed determine the expression target genes. Function experiments showed effects miR-365a-3p on cell growth.HCG18 increased lines. Moreover, vitro vivo demonstrated that knockdown inhibited proliferation. Mechanistically, defined as competing endogenous by...
The Hippo pathway is an evolutionarily conserved regulator of tissue growth and cell fate during development regeneration. Conversely, deregulation the has been reported in several malignancies. Here, we used integrative functional genomics approaches to identify TAZ, a transcription co-activator key downstream effector pathway, as essential driver for propagation TNBC malignant phenotype. We further showed non-transformed human mammary basal epithelial cells that expression constitutively...
The study aims to establish a pre-academic diagnostic tool based on deep learning and conventional radiomics features guide the clinical decision-making of parapharyngeal space (PPS) tumors. This retrospective included 217 patients with PPS tumors, from two medical centers in China March 1, 2011, October 2023. cohort was divided into training set (n = 145) test 72). A (DL) model (Rad) neck MRI were constructed distinguish malignant tumors (MTs) benign (BTs) (DLR) which integrates further...
Vitamin D (VitD) deficiency is prevalent in more than half of patients treated with antiepileptic drugs. The number seizures decreases by 40% after vitamin D3 supplementation. This study aimed to investigate the effects using an vivo epileptic model. Sprague-Dawley rats received pentylenetetrazole (i.p.) treatment induce epilepsy and were then sodium valproate, VitD, or a combination VitD paricalcitol. improved behavior, as evidenced increased latency time significant reduction scores on...
To investigate the underlying mechanism by which CXCL12 and CXCL6 influences metastatic potential of colon cancer internal relation stromal cells.Western blotting was used to detect expression in cells cells. The co-operative effects on proliferation invasion human umbilical vein endothelial (HUVECs) were determined enzyme-linked immunosorbent assay, assays. angiogenesis HUVECs through interaction with examined assay. We eventually investigated activation PI3K/Akt/mTOR signaling involved...
We develop a fiber optical coherence tomography (OCT) system in the clinical utility of imaging port wine stains (PWS). use our OCT on 41 patients with PWS to document difference between skin and contralateral normal skin. The system, which operates at 4 frames/s axial transverse resolutions 10 9 µm, respectively, tissue, can clearly distinguish dilated dermal blood vessels from tissue. present images human obtain structural parameters, including epidermal thickness diameter depth vessels....
Abstract In metastasis, the cancer cells that travel through body are capable of establishing new tumors in locations remote from site original disease. To metastasize, a cell must break away its tumor and invade either circulatory or lymphatic system, which will carry it to location, establish itself site. Once blood stream, now have access every portion body. Here, we used “in vivo flow cytometer” study if there is any relationship between metastatic potential depletion kinetics...
Abstract: Activation of the calcium-sensing receptor (CaSR) leads to an increase intracellular calcium concentration and alteration cellular activities. High level is involved in hypoxia-induced proliferation pulmonary arterial smooth muscle cells (PASMCs). However, whether CaSR expressed PAMSCs related PASMCs unclear. In this study, expression distribution CaSRs were detected by RT-PCR, western blotting immunofluorescence; free ([Ca2+]i) was determined confocal laser scanning microscopy;...
Abstract Background The extracellular calcium-sensing receptor (CaSR) belongs to family C of the G protein coupled receptors. Whether CaSR is expressed in pulmonary artery (PA) unknown. Methods expression and distribution were detected by RT-PCR, Western blotting immunofluorescence. PA tension was arterial ring technique, intracellular calcium concentration ([Ca 2+ ] i ) a laser-scanning confocal microscope. Results expressions mRNA found both rat smooth muscle cells (PASMCs) PAs. Increased...
// Costa Frangou 1, * , Ying-Wei Li He Shen 1 Nuo Yang Kayla E. Wilson Maxime Blijlevens Jin Guo Norma J. Nowak 2 Jianmin Zhang Department of Cancer Genetics, Roswell Park Institute, Buffalo, NY, 14263, USA Biochemistry, School Medicine and Biomedical Sciences, University at The State New York, 14260, These authors contributed equally to this work Correspondence to: Zhang, e-mail: jianmin.zhang@roswellpark.org Keywords: breast cancer, TAZ, tumor-initiating cells, RNA sequencing, Dasatinib...
Summary 1. Acute myocardial infarction (AMI) is strongly associated with atherosclerosis, and responsible for significant morbidity mortality worldwide. The pathogenic mechanisms that underlie atherosclerosis AMI are undefined at present. calcium‐sensing receptor (CaSR) a member of the superfamily G‐protein coupled receptors. It has been demonstrated previously expression CaSR increased in atherosclerotic cardiac tissue rats. also suggested crucial role ischaemia–reperfusion injury,...
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate tumorigenesis. pivotal effector of this is YAP1, a transcriptional co-activator amplified in mouse human cancers where it promotes epithelial-to-mesenchymal transition (EMT) malignant transformation. tumor suppressor has been suggested to inhibit the YAP1 function through serine phosphorylation-induced cytoplasmic retention degradation. Here we report that tyrosine188...
Structural colors produced from nanostructures have attracted much attention due to their promising advantages of long-term stability and high resolution. Many like metasurfaces been demonstrated generate color information in the transmission or reflection mode. Here, a strategy combining polarization-insensitive polarization-sensitive transmissive structural is proposed realize convenient diverse encrypted pattern designs. A two-dimensional metasurface, whose polarization characteristics...
To explore the value of different inflammatory markers in predicting severity coronavirus disease 2019 (COVID-19) patients with type 2 diabetes mellitus (T2DM).