A5027475033- Fungal Biology and Applications
- Advanced Proteomics Techniques and Applications
- Protein Hydrolysis and Bioactive Peptides
- Medicinal Plants and Bioactive Compounds
- Trace Elements in Health
- Clinical Laboratory Practices and Quality Control
- Diet and metabolism studies
- Proteins in Food Systems
- Pain Mechanisms and Treatments
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Microencapsulation and Drying Processes
- Fatty Acid Research and Health
- Epilepsy research and treatment
- Traditional Chinese Medicine Analysis
- Cholesterol and Lipid Metabolism
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Neonatal and fetal brain pathology
- Parkinson's Disease Mechanisms and Treatments
- Infant Nutrition and Health
- Muscle metabolism and nutrition
- Enzyme Production and Characterization
- Mathematical and Theoretical Epidemiology and Ecology Models
University of Greenwich
2022-2025
Carleton University
2024
Liaoning Provincial People's Hospital
2024
China Medical University
2013-2024
Zhejiang Gongshang University
2022-2024
Chinese Academy of Fishery Sciences
2024
South China University of Technology
2024
Qinghai University Affiliated Hospital
2024
Dalian Polytechnic University
2024
California Maritime Academy
2023
Aiming to provide a basis for the application of
Spinal cord injury (SCI) is a devastating disease, which results in tissue loss and neurologic dysfunction. NLRP3 inflammasome plays an important role the mechanism of diverse diseases. However, no studies have demonstrated effects inhibitors mouse model SCI. We investigated whether inhibition activation by pharmacologic inhibitor BAY 11-7082 or A438079 could exert neuroprotective SCI.SCI was performed using aneurysm clip with closing force 30 g at level T6-T7 vertebra for 1 min. Motor...
Abstract Despite recent advances in the treatment of Parkinson disease (PD), levodopa remains most effective and widely used therapy. A major limitation to use is development abnormal involuntary movements, termed levodopa‐induced dyskinesia (LDID), following chronic treatment. Since studies have suggested that modifications chromatin structure may be responsible for many long‐lasting changes brain function, we examined post‐translational striatal histones two models LDID: an acute murine...
Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated current therapies. Although association between bladder pathology circRNAs undetermined, signatures may be useful as prognostic predictive factors clinical tools for assessing state, treatment response outcome. This study investigates if these can used biomarkers diagnosis predicting response. Herein, qPCR measured expression hsa_circRNA_100783, hsa_circ_0000285...
We report the results of a systematic investigation to quantify losses protein during well-established two-dimensional polyacrylamide gel electrophoresis (2-DE) procedure. Radioactively labelled proteins ([(14)C]bovine serum albumin and homogenate prepared from liver rat that had been injected with [(35)S]methionine) were used, recovery was quantified by digesting pieces in H(2)O(2) subjecting digests liquid scintillation counting. When samples loaded onto first dimension immobilised pH...
Conventional tools for measuring dietary exposure have well recognized limitations. Measurement of food-derived metabolites in biofluids provides an alternative approach and our aim was to develop experimental protocol which ensures that extraneous variability does not obscure metabolic signals from ingested foods. Healthy adults consumed a standardized meal the evening before each test day collected pooled overnight urine. On three different studies, urine fasted state at time points after...
polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This designed to investigate its and mechanism using a rat model induced by streptozotocin (50 mg/kg, i.p.). The rats were treated with GLP (300 mg/kg/day) for 10 weeks. blood glucose, glycated hemoglobin, body weight, levels of creatinine, urea nitrogen, urine protein assessed. And pathologies assessed tissue sections stained hematoxylin-eosin, Masson's trichome, periodic acid-Schiff....
The classic view of anatomofunctional organization the basal ganglia is that striatopallidal neurons “indirect” pathway express D 2 dopamine receptors and corelease enkephalin with GABA, whereas “direct” bear 1 dynorphin substance P GABA. Although many studies have investigated pathophysiology after denervation subsequent chronic levodopa ( l -dopa) treatment, none has ever considered possibility plastic changes leading to profound reorganization and/or biochemical phenotype modifications...
Low shear stress and pyroptosis both play an important role in the onset development of atherosclerosis (AS). MicroRNAs (miRNAs) are a kind short (18-22) nucleotide sequences that can bind to 3'-untranslated region (3'-UTR) messenger RNA, thereby regulating programmed cell death including pyroptosis. However, function miRNAs cells subjected conditions is unknown. Therefore, we conducted current study demonstrate effect low on underlying mechanism. Human umbilical vein endothelial (HUVECs)...
Gracilariopsis lemaneiformis ( G. ) protein was hydrolyzed with alkaline protease to obtain antioxidant peptides. The enzymatic hydrolysis conditions were optimized through single-factor and orthogonal experiments. results showed that the optimal process parameters using 2% of protease, substrate concentration 1 g/100 mL 2 h at pH 8.0. Gel filtration chromatography RP-HPLC adopted for isolating purifying peptides from hydrolysate (GLPH). Three novel identified as LSPGEL (614.68 Da), VYFDR...
Vitamin D (VitD) deficiency is prevalent in more than half of patients treated with antiepileptic drugs. The number seizures decreases by 40% after vitamin D3 supplementation. This study aimed to investigate the effects using an vivo epileptic model. Sprague-Dawley rats received pentylenetetrazole (i.p.) treatment induce epilepsy and were then sodium valproate, VitD, or a combination VitD paricalcitol. improved behavior, as evidenced increased latency time significant reduction scores on...
Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated mechanism by giving treatments placebo, cyclophosphamide, paeonol 150 and 300 mg/kg to 4 groups mice bearing EMT6 breast cancer. Apoptosis tumor cells were confirmed morphology analysis, including hematoxylin, eosin staining TUNEL staining. The results showed...