A5100662820- Berberine and alkaloids research
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Drug Transport and Resistance Mechanisms
- Chromatography in Natural Products
- Gut microbiota and health
- Cholesterol and Lipid Metabolism
- Natural product bioactivities and synthesis
- Plant Reproductive Biology
- MicroRNA in disease regulation
- Alkaloids: synthesis and pharmacology
- Helicobacter pylori-related gastroenterology studies
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Ginseng Biological Effects and Applications
- Diet, Metabolism, and Disease
- Medicinal Plant Pharmacodynamics Research
- Cancer Mechanisms and Therapy
- Synthesis and bioactivity of alkaloids
- Liver Disease Diagnosis and Treatment
- Bioactive natural compounds
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Phytochemical Studies and Bioactivities
- Antibiotic Resistance in Bacteria
Southwest University
2016-2025
Children's Hospital of Zhejiang University
2023-2024
Office for National Statistics
2024
Kennedy Krieger Institute
2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Taiyuan University of Technology
2023
Huangshan University
2023
Guizhou Normal University
2020-2022
Wenzhou Medical University
2022
Hypoglycemic activity-guided separation of ethanol extracts from the fruits Cornus officinalis Sieb. et Zucc (CO) led to isolation loganin, morroniside, and ursolic acid. The antidiabetic capacity CO related compounds was further investigated in diabetes mellitus mice. results suggested that both pure could ameliorate diabetes-associated damages complications. Oral administration loganin morroniside decreased fasting blood glucose levels Ursolic acid exhibited highest reactive oxygen species...
This study was conducted to evaluate the antihyperlipidemic activity of five major alkaloids in Rhizoma Coptidis using high-fat- and high-cholesterol-induced hyperlipidemic hamsters. Hyperlipidemic hamsters were treated with coptisine, berberine, jatrorrhizine, palmatine, epiberberine, total a dose 46.7 mg/kg × day for 140 days. Serum cholesterol, triglyceride, high-density lipoprotein low-density bile acids examined after alkaloid treatment. The results showed that all therapy agents...
Abstract Colorectal cancer is one of the most common causes cancer-related death in humans. Coptisine (COP) a natural alkaloid from Coptidis Rhizoma with unclear antitumor mechanism. Human colon cells (HCT-116) and xenograft mice were used to systematically explore anti-tumor activity COP this study. The results indicated that exhibited remarkably cytotoxic activities against HCT-116 by inducing G 1 -phase cell cycle arrest increasing apoptosis, preferentially inhibited survival pathway...
Preclinical Research Rhizoma Coptidis (RC), the root of Coptis chinensis Franch, a species in genus (family Ranunculaceae), has been commonly prescribed for treatment diabetes Chinese traditional herbal medicine applications. The present study is focused on assessment antihyperglycemia and antidiabetic hyperlipidemia effect five protoberberine alkaloids, berberine (BBR), coptisine (COP), palmatine (PAL), epiberberine (EPI), jatrorrhizine (JAT), separated from R. hepatocellular carcinoma...
Breast cancer (BC) is a prominent source of mortality in women throughout the world. β-Sitosterol-d-glucoside (β-SDG), newly isolated phytosterol from sweet potato, possibly displays potent anticancer activity. However, probable mechanisms involved are still unclear. This study sought to how β-SDG potato affects two BC cell lines (MCF7 and MDA-MB-231) nude mice bearing MCF7-induced tumors. In addition, we assessed tumor suppressor miR-10a PI3K-Akt signaling cells. Cell viability...