A5078936529- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Geological and Geochemical Analysis
- earthquake and tectonic studies
- Virus-based gene therapy research
- High-pressure geophysics and materials
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Berberine and alkaloids research
- Advanced Drug Delivery Systems
- Microbial Inactivation Methods
- Microencapsulation and Drying Processes
- Ultrasound and Cavitation Phenomena
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Solubulity and Delivery Systems
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Macrophage Migration Inhibitory Factor
- Mineralogy and Gemology Studies
Sun Yat-sen University
2016-2025
Sichuan Normal University
2024-2025
Guangzhou University of Chinese Medicine
2024
Jiangnan University
2024
South China Agricultural University
2024
State Key Laboratory of Food Science and Technology
2024
East China University of Technology
2024
Jiangsu University
2021-2023
Weatherford College
2021
Xinjiang Medical University
2021
Polyethylenimine (PEI) is a class of cationic polymers proven to be effective for gene delivery. However, PEI nondegradable and the molecular weight affects cytotoxicity transfer activity. Aiming prepare biodegradable vector with high transfection efficiency low cytotoxicity, we conjugated (LMW) PEIs backbone polyglutamic acids derivative (PEG-b-PBLG) by aminolysis form combined PEG-b-PLG-g-PEIs (GGI). Two copolymers, GGI 30 40, were synthesized. The chemistry was characterized using IR, 1H...
Nominally anhydrous minerals in 46 peridotite xenoliths hosted by Cenozoic basalts from five localities (Fangshan, Penglai, Qixia, Changle, and Hebi) of the eastern part North China Craton (NCC) have been investigated Fourier transform infrared spectrometry (FTIR). The water contents (H 2 O wt %) clinopyroxene (cpx), orthopyroxene (opx), olivine (ol) range 27 to 223 ppm, 8 94 ∼0 respectively. On basis (1) homogenous H content within single pyroxene grains (2) equilibrium partitioning between...
It is extremely difficult for cancer chemotherapy to control the peritoneal metastasis of advanced ovarian carcinoma given its inability target disseminated tumors and severe toxic side effects on healthy organs. Here, we report antitumor M1 macrophages developed as live-cell carriers that deliver anticancer drugs treatment metastatic carcinoma. Engineered doxorubicin-loaded (M1-Dox) significantly enhanced tumor tropism by upregulation CCR2 CCR4 compared with their parent cells. Meanwhile,...
Mitochondrial transplantation is a significant therapeutic approach for addressing mitochondrial dysfunction in patients with spinal cord injury (SCI), yet it limited by rapid deactivation and low transfer efficiency. Here, high-quality mitochondria microfactories (HQ-Mitofactories) were constructed anchoring Prussian blue nanoenzymes onto mesenchymal stem cells effective to treat paralysis from SCI. Notably, the results demonstrated that HQ-Mitofactories could continuously produce...
Spherical, well-defined core−shell nanoparticles that consist of poly(methyl methacrylate) (PMMA) cores and branched poly(ethylenimine) shells (PEI) were synthesized via a graft copolymerization methyl methacrylate from PEI induced by small amount tert-butyl hydroperoxide. The PMMA-PEI between 130 to170 nm in diameter displayed zeta-potentials near +40 mV at pH 7 1 mM aqueous NaCl. Plasmid DNA (pDNA) was mixed with formed complexes approximately 120 highly monodispersed. characterized...
An ideal gene carrier is required both in safety and efficiency for transfection. Polyethylenimine (PEI), a well-studied cationic polymer, has been proved with high transfection efficiency, but reported as toxicity many cell lines. In this study, PEI was coupled polyethylene glycol (PEG) to reduce its cytotoxicity. PEG-PEI copolymers were synthesized isoporon diisocyanate (IPDI) two steps. A set of different PEG molecular weights (MWs) amounts synthesized. The structure the resulting...
Hypoglycemic activity-guided separation of ethanol extracts from the fruits Cornus officinalis Sieb. et Zucc (CO) led to isolation loganin, morroniside, and ursolic acid. The antidiabetic capacity CO related compounds was further investigated in diabetes mellitus mice. results suggested that both pure could ameliorate diabetes-associated damages complications. Oral administration loganin morroniside decreased fasting blood glucose levels Ursolic acid exhibited highest reactive oxygen species...
The genesis of Cenozoic continental basalts in Eastern China is highly debated. Subducted oceanic crust (most probably the Pacific slab) has been increasingly suggested to be involved their mantle source. Taihang Mountains are located at a surface position corresponding western edge stagnant subducted slab revealed by geophysical investigations, and thus provide an opportunity study spatial extent effect subduction on characteristics China. In previous studies, alkali from were considered...