A5038205663- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Virus-based gene therapy research
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Polymer-Based Agricultural Enhancements
- Landslides and related hazards
- DNA and Nucleic Acid Chemistry
- Supramolecular Self-Assembly in Materials
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Reproductive System and Pregnancy
- Electrospun Nanofibers in Biomedical Applications
- Adsorption and biosorption for pollutant removal
- Advanced Drug Delivery Systems
- Mathematical Dynamics and Fractals
- Carbon dioxide utilization in catalysis
- Arsenic contamination and mitigation
- Heavy metals in environment
- Stochastic processes and statistical mechanics
- Biopolymer Synthesis and Applications
- Topological and Geometric Data Analysis
- Covalent Organic Framework Applications
National University of Singapore
2016-2025
Suzhou Research Institute
2024-2025
Suzhou Municipal Hospital
2025
Nanjing Medical University
2020-2025
Jiangsu Province Hospital
2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Ninth Hospital of Nanchang
2025
Hunan Agricultural University
2021-2024
West China Hospital of Sichuan University
2024
In this work, we have synthesized a thermoresponsive copolymer, alginate-g-poly(N-isopropylacrylamide) (alginate-g-PNIPAAm) by conjugating PNIPAAm to alginate, where with different molecular weights and narrow weight distribution was atomic transfer radical polymerization. The copolymer dissolved in water or phosphate-buffered saline buffer solution at room temperature formed self-assembled micelles low critical micellization concentrations when the increased above their temperatures. At...
Polyethylenimine (PEI) is a class of cationic polymers proven to be effective for gene delivery. However, PEI nondegradable and the molecular weight affects cytotoxicity transfer activity. Aiming prepare biodegradable vector with high transfection efficiency low cytotoxicity, we conjugated (LMW) PEIs backbone polyglutamic acids derivative (PEG-b-PBLG) by aminolysis form combined PEG-b-PLG-g-PEIs (GGI). Two copolymers, GGI 30 40, were synthesized. The chemistry was characterized using IR, 1H...
It has been a challenge to incorporate multiple features into single gene carrier system overcome numerous hurdles during the delivery. Herein, supramolecular approach for building multifunctional is demonstrated with functions of disulfide bond based reduction‐responsive degradation and zwitterionic phosphorylcholine extracellular stabilization favorable cellular uptake. The self‐assembled from two molecular blocks: one host polymer, which redox‐sensitive β‐cyclodextrin cationic star guest...
Supramolecular hydrogels based on inclusion complexation between cyclodextrins (CDs) and polymers have attracted much interest because of their potential for biomedical applications. It is also attractive to incorporate stimuli-responsive properties into the system create "smart" hydrogels. Herein, a poly(N-isopropylacrylamide) (PNIPAAm) star polymer with β-CD core an adamantyl-terminated poly(ethylene glycol) (Ad-PEG) were synthesized. They self-assembled thermoresponsive pseudo-block...
The escalating frequency of thallium (Tl) contamination incidents amplifies its environmental risk. However, the potential risk Tl to aquatic organisms, especially across varying developmental stages, remains poorly understood. In this study, we employed zebrafish as a representative model organism and exposed embryos larvae at distinct periods (specifically, 6 h postfertilization (hpf) 72 hpf) low concentrations Tl(I) (0.25 0.50 mg/L). exposure was performed for short duration 24 h,...
We developed a supramolecular system for codelivery of doxorubicin (Dox) and p53 gene based on β-CD-containing star-shaped cationic polymer. First, polymer consisting β-CD core 3 arms oligoethylenimine (OEI), named CD-OEI, was used to form inclusion complex with hydrophobic Dox. The CD-OEI/Dox subsequently condense plasmid DNA via electrostatic interactions CD-OEI/Dox/DNA polyplex nanoparticles positive surface charges that enhanced the cellular uptake both Dox DNA. This drug showed high...
Paclitaxel (PTX), a hydrophobic anticancer drug, is facing several clinical limitations such as low bioavailability and drug resistance. To solve the problems, well-defined β-cyclodextrin-poly(N-isopropylacrylamide) star polymer was synthesized used nanocarrier to improve water solubility aim thermoresponsive delivery of PTX cancer cells. The able form supramolecular self-assembled inclusion complex with via host–guest interaction at room temperature, which below critical solution...
A tumor-targeted surface charge switchable polymeric gene delivery system with the function of switching upon reaching tumor site owing to extracellular pH (pHe) was developed. The fabricated by two steps. First, positively charged polyplexe nanoparticles were formed between β-cyclodextrin-oligoethylenimine star polymer (CD-OEI) and plasmid DNA (pDNA). Next, CD-OEI/pDNA polyplex coated a pHe-responsive anionic via an electrostatic interaction form ternary complexes. block copolymers...
It requires multistep synthesis and conjugation processes to incorporate multifunctionalities into a polyplex gene vehicle overcome numerous hurdles during delivery. Here, we describe supramolecular platform precisely control, screen, optimize molecular architectures of siRNA targeted delivery vehicles, which is based on rationally designed host-guest complexation between β-cyclodextrin-based cationic host polymer library guest polymers with various PEG shape size, density ligands. The...
Water pollution by various toxic substances remains a serious environmental problem, especially the occurrence of organic micropollutants including endocrine disruptors, pharmaceutical pollutants and naphthol pollutants. Adsorption process has been an effective method for pollutant removal in wastewater treatment. However, thermal regeneration most widely used activated carbon is costly energy-consuming. Therefore, there increasing need to develop alternative low-cost adsorption materials...
Okara is a food waste produced from the soybean milk and curd industries has been identified as suitable candidate for development of bio-based functional materials. Here, we report design, synthesis, characterization superabsorbent hydrogels through graft copolymerization okara with acrylic acid (AA) acrylamide (AAm). The suspension fine particles was activated ammonium persulfate, which then initiated free radical polymerization to randomly poly(acrylic acid) (PAA) polyacrylamide (PAAm)...
EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon that may lead to expensive, time-consuming, and invasive diagnostic procedures as well unnecessary patient treatment. The purpose of this study was explore the effects time, anticoagulant detection channel on platelet (PLT) count EDTA-PTCP samples, suggest a better method for correcting spurious low PLT counts. In study, 43 identified samples were collected. Sysmex XN-9100, Mindray BC-6900 BC-5390 haematology...