A5101455861- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Methemoglobinemia and Tumor Lysis Syndrome
- Heart Failure Treatment and Management
- Pharmacovigilance and Adverse Drug Reactions
- Plant nutrient uptake and metabolism
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Blood disorders and treatments
- Drug-Induced Adverse Reactions
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Function and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Medicinal Plants and Bioactive Compounds
- Plant Gene Expression Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Diabetes Treatment and Management
- Congenital heart defects research
- Pesticide and Herbicide Environmental Studies
- MicroRNA in disease regulation
Central South University
2021-2024
Second Xiangya Hospital of Central South University
2021-2024
China Agricultural University
2024
Guangdong Academy of Medical Sciences
2015-2023
Guangdong Provincial People's Hospital
2022-2023
Guangdong General Hospital
2015-2021
University of Toyama
2019
Jiangnan University
2017
State Key Laboratory of Food Science and Technology
2017
Southwest University
2015
Although some tumor lysis syndrome (TLS) cases have been reported with patients multiple myeloma (MM) taking monoclonal antibodies (mAbs), the association between TLS and mAbs remains mostly unknown. We aim to investigate describe clinical features. conducted a disproportionality analysis link by excluding known confounders compared other anticancer drugs. The was evaluated using information component (IC). Drug–drug interaction signals were calculated based on Ω shrinkage measure....
Inflammation has been shown to play a critical role in the development of many diseases. In this study, we used metabolomics evaluate inflammatory effect lipopolysaccharide (LPS) and anti-inflammatory glabridin (GB, polyphenol from Glycurrhiza glabra L. roots) RAW 264.7 cells. Multivariate statistical analysis showed that comparison with LPS group, metabolic profile GB group was more similar control group. impacted amino acid, energy, lipid metabolisms cells, pathway reversed some those...
Background: Pneumocystis jirovecii pneumonia (PJP) has been reported with ICIs but limited to case reports. The clinical features of PJP remain mostly unknown. This study aims investigate the association and describe features. Methods: Reports recorded in FAERS (January 2004-December 2022) were identified through preferred term "Pneumocystis pneumonia". Demographic described, disproportionality signals assessed Reporting Odds Ratio (ROR) Information Component (IC), using traditional...
Crizotinib carries an FDA hepatotoxicity warning, yet analysis of the FAERS database suggests that severity its risks, including progression to hepatitis and liver failure, might be underreported. However, underlying mechanism remains poorly understood, effective intervention strategies are lacking. Here, mRNA-sequencing analysis, along with KEGG GO analyses, revealed DEGs linked Crizotinib-induced predominantly associate ferroptosis pathway which was identified as principal behind...
Liver disease has emerged as a significant worldwide health challenge due to its diverse causative factors and therapeutic complexities. The majority of liver diseases ultimately progress end-stage transplantation remains the only effective therapy with limitations donor organ shortage, lifelong immunosuppressants expensive treatment costs. Numerous pre-clinical studies have revealed that extracellular vesicles released by mesenchymal stem cells (MSC-EV) exhibited considerable potential in...
Introduction: Antibody-drug conjugates (ADCs) produce unparalleled efficacy in refractory neoplasms but can also lead to serious toxicities. Although ADC-related sepsis has been reported, the clinical features are not well characterized real-world studies. Objective: The aim of this study was identify association between ADCs and using FAERS data uncover characteristics sepsis. Methods: We performed disproportionality analysis compared rates cancer patients receiving vs. other regimens....
Background: Although some sepsis cases were reported with immune checkpoint inhibitors (ICIs) in clinical trials, the link between pulmonary and ICIs remains mostly unknown. We aim to investigate association ICIs, describe features. Methods: A disproportionality analysis was performed using FAERS data compared rates of cancer patients receiving vs. other drug regimens (such as chemotherapy targeted therapy). Associations assessed reporting odds ratios (ROR) information component (IC). also...
Emerging evidence has shown that aldosterone blockers reduced the incidence of ventricular arrhythmias in patients with myocardial infarction (MI). However, mechanism remains unknown. In this study, we investigated by which spironolactone, a classic blocker, regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN) protein expression ischemic rat myocardium after MI. Eighteen rats surviving 24 hours MI were randomly assigned into 3 groups: MI, and spironolactone +...
Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, regulator EMT, involved in fibrosis. In this study, we explored the expression patterns Snail1 and a marker-periostin-after MI mice then investigated co-expression between periostin mice. Our results showed that mRNA protein levels were significantly increased infarct area. The pattern appeared to be parabolic within 14 days MI....
Background and purpose: The potential impact of dapagliflozin on the urinary albumin-to-creatinine ratio (UACR) in patients with type 2 diabetes cardiovascular disease remained inconclusive. We aimed to investigate UACR mellitus complicated disease. Methods: This is a single-center prospective observation study. Diabetic were recruited at authors’ center (both outpatients inpatients) during period from June 2019 November 2020. study subjects grouped into group (receiving for least 6...
Cardiovascular complications are a leading cause of mortality in patients with diabetes mellitus (DM). The present study was designed to investigate the effects trimetazidine (TMZ), an anti-angina drug, on transient outward potassium current (Ito) remodeling ventricular myocytes and plasma contents free fatty acid (FFA) glucose DM. Sprague-Dawley rats, 8 weeks old weighing 200-250 g, were randomly divided into three groups 20 animals each. control group injected vehicle (1 mM citrate...
Objective: This study aimed to investigate the potential association between biological disease-modifying antirheumatic drugs (bDMARDs) and pericarditis uncover relevant clinical characteristics in ankylosing spondylitis (AS). Methods: Reports of recorded FDA Adverse Event Reporting System (FAERS) (January 2004–December 2022) were identified through preferred term “pericarditis.” Demographic described, disproportionality signals assessed reporting odds ratio (ROR) information component (IC)....
To investigate the potential association between tumor lysis syndrome (TLS) and drugs for treatment of malignant melanoma (MM).