A5101892586- Biomarkers in Disease Mechanisms
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
- interferon and immune responses
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Viral Infections and Immunology Research
- Calcium signaling and nucleotide metabolism
- Sphingolipid Metabolism and Signaling
- Medicinal Plants and Bioactive Compounds
- Venous Thromboembolism Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Heat shock proteins research
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Endometriosis Research and Treatment
- Glutathione Transferases and Polymorphisms
China Medical University
2013-2021
Fourth Affiliated Hospital of China Medical University
2013-2021
Yanbian University
2007
Low shear stress and pyroptosis both play an important role in the onset development of atherosclerosis (AS). MicroRNAs (miRNAs) are a kind short (18-22) nucleotide sequences that can bind to 3'-untranslated region (3'-UTR) messenger RNA, thereby regulating programmed cell death including pyroptosis. However, function miRNAs cells subjected conditions is unknown. Therefore, we conducted current study demonstrate effect low on underlying mechanism. Human umbilical vein endothelial (HUVECs)...
Abstract Ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) are the two most common etiologies of failure (HF). Both forms share characteristics including ventricle dilation in final stage. Immune mechanisms HF increasingly highlighted have been implicated pathogeneses IHD DCM. A better understanding adhesion molecule expression correlated immune cell infiltration could enhance detection improve therapeutic targets. This study was performed to explore underlying After searching...
Background:Impairment of coronary flow reserve (CFR) has been generally demonstrated in diabetic patients and animals with microvascular complications but without obvious obstructive atherosclerosis. There have few studies investigating CFR cases relatively well-controlled therapy. The purpose this study is to evaluate the effect treatment a Sphingosine-1-phosphate (S1P) receptor potent agonist, FTY720, on early rats terms CFR.Methods Results:Male Sprague-Dawley (SD) were divided into 3...
To investigate if microRNAs (miRNAs) play a role in regulating h-ERG trafficking the setting of chronic oxidative stress as common deleterious factor for many cardiac disorders.We treated neonatal rat ventricular myocytes and HEK293 cells with stable expression H2O2 12 h 48 h. Expression miR-17-5p seed miRNAs was quantified by real-time RT-PCR. Protein levels chaperones were measured Western blot analysis. Luciferase reporter gene assay used to study miRNA target interactions. Whole-cell...