Machine learning provides increasingly reliable assistance for medical experts in diagnosing coronary heart disease. This study proposes a deep hybrid model based disease (CAD) prediction method, which can significantly improve the accuracy compared to traditional solutions. research scheme is on data of 7291 patients and model, uses two different neural network models recurrent as main training. The results training use k-nearest neighbor secondary so prediction. comparison between clinical...

Stem cells transplanted to the ischemic myocardium usually encounter massive cell death within a few days after transplantation, and hypoxic preconditioning (HPC) is currently used as strategy prepare stem for increased survival engraftment in heart. The purpose of this study determine whether Pim-1 kinase mediates any beneficial effects HPC human cardiac progenitor (CPCs). Human CPCs were isolated from an adult heart auricle purified by magnetic-activated sorting using c-kit magnetic beads;...

Background Nε-carboxymethyl-lysine (CML) is a major advanced glycation end-product (AGEs) widely found in foods. The aim of our study was to evaluate how exogenous CML-peptide dynamically absorbed from the gastrointestinal tract and eliminated by renal tubular secretion using microPET imaging. Methods present consisted three investigations. In I, we synthesized imaging tracer 18F-CML reacting N-succinimidyl 4-18F-fluorobenzoate (18F-SFB) with CML. II, biological activity evaluated RAW264.7...

The purpose of this study was to develop a coronary artery disease (CAD) prediction model that optimally estimates the pre-test probability CAD for patients suspected CAD.This retrospective, multi-centre included 7360 consecutive (4678 men, 57.87±11.42 years old; 2682 women, 61.60±9.58 old) who underwent angiography evaluation CAD. A fitted diagnosis with help eight significant risk factors including sex, age, smoking status, diabetes, hypertension, dyslipidaemia, serum creatinine and...

Heart disease is one of the most important causes death in developed countries. Nε-carboxymethyllysine (CML) a major advanced glycation end product formed by combined reactions non-enzymatic and oxidation (glycoxidation), it represents general marker oxidative stress. CML has been suggested to be involved pathogenesis heart disease. Plasma elevated aging, atherosclerosis and/or diabetes. In this study, we measured cardiac levels elucidate its role Cardiac tissues were collected from 105...

Background:Impairment of coronary flow reserve (CFR) has been generally demonstrated in diabetic patients and animals with microvascular complications but without obvious obstructive atherosclerosis. There have few studies investigating CFR cases relatively well-controlled therapy. The purpose this study is to evaluate the effect treatment a Sphingosine-1-phosphate (S1P) receptor potent agonist, FTY720, on early rats terms CFR.Methods Results:Male Sprague-Dawley (SD) were divided into 3...

Abstract Objective: To study the relationship of Nε-(carboxymethyl)-lysine level (CML) with microstructure changes white matter (WM), and cognitive impairment in patients type 2 diabetes mellitus (T2DM) to discuss potential mechanism underlying T2DM-associated impairment. Methods: The was performed T2DM (n=22) disease course ≥5 years age ranging from 65 75 old. A control group consisted 25 sex- age-matched healthy volunteers. Fractional anisotropy (FA) several WM regions analyzed by...

Recent studies have found that cardiac stem cells (CSCs) are present in the adult heart. CSCs play an important role maintaining balance of number myocardial cells. The purpose this study was to examine characteristics human and their correlation with clinical patients. We collected heart auricles 105 patients (age range, 1–78 years; mean, 55.6 ± 17.0 years) undergoing surgery obtain CSCs. assayed percentage c-kit positive (c-kit + ) flow cytometry. Plasma N ɛ -(carboxymethyl)lysine (CML)...

The coronary artery hemodynamics are impacted by both the macrocirculation and microcirculation. Whether microcirculation load impact functional assessment of a stenosis is unknown. purpose this study to investigate effect porous media on fractional flow reserve (FFR) in stenotic model.A three dimensional computational simulation blood symmetric model was constructed. fluid dynamics (CFD) developed with Fluent 16.0. Blood modeled as shear thinning, non-Newtonian Carreau model. A seepage...

<abstract><p>With the widespread adoption of electronic health records, amount stored medical data has been increasing. Clinical data, often in form semi-structured or unstructured records (EMRs), contains rich patient information. However, due to use natural language by physicians when composing these effectiveness traditional methods such as dictionaries, rule matching, and machine learning extraction information from texts falls short clinical standards. In this paper, a novel...

Acute myocardial infarction (AMI) remains a leading cause of hospitalization and death in China. Accurate mortality prediction inpatient is crucial for clinical decision-making non-ST-segment elevation (NSTEMI) patients.

<abstract><p>The data input process for most chest pain centers is not intelligent, requiring a lot of staff to manually patient information. This leads problems such as long processing times, high potential errors, an inability access in timely manner and increasing workload. To address the challenge, Internet Things (IoT)-driven center designed, which crosses sensing layer, network layer application layer. The system enables construction intelligent management through...

Objective: To investigate potential value of fibrin related markers in patients with femoral fracture during perioperative period. Methods: Ninety-five were enrolled, including 39 males (53±24) years old and 56 females (73±13) old, which 44 on caput femoris, 34 collum femoris 17 shaft femur. Sampling the day before operation 1(st,) 3(rd,) 5(th) days after operation, monomer (FM), D-dimer(DD), fibrinogen degradation product (FDP) other coagulation assays detected by reagents from Stago....

Abstract Background: The object of the study is to investigate effect coronary tortuosity (CT) on fractional flow reserve (FFR) in stenotic artery. Methods: A three dimensional computational model simulation blood artery with multi-bend CT was constructed Fluent 16.0 software. Blood simulated as non-Newtonian fluid Carreau model. used by finite element methods condition and no (NCT). Coronary hemodynamic parameters such pressure, velocity physiological diagnostic parameter were studied...