A5027892224- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Parasite Biology and Host Interactions
- Cytomegalovirus and herpesvirus research
- Helminth infection and control
- Rabies epidemiology and control
- Parasites and Host Interactions
- Viral Infections and Vectors
- Reproductive tract infections research
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- Amoebic Infections and Treatments
- Respiratory viral infections research
- interferon and immune responses
- Parasitic infections in humans and animals
- Heme Oxygenase-1 and Carbon Monoxide
- Hepatitis B Virus Studies
- Sex work and related issues
- Vector-Borne Animal Diseases
- MicroRNA in disease regulation
- Hepatitis C virus research
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial infections and disease research
Fujian Agriculture and Forestry University
2018-2025
Nankai University
2024
Fourth Affiliated Hospital of China Medical University
2014-2020
China Medical University
2013-2020
Beijing University of Chinese Medicine
2020
Chinese Academy of Agricultural Sciences
2011-2019
Lanzhou Veterinary Research Institute
2010-2019
Tianjin Medical University
2018
Sun Yat-sen University
2015
Sun Yat-sen Memorial Hospital
2015
Significance A majority of emerging infectious diseases in humans are transmitted from animals. It is generally agreed that our behavior can influence exposure to such pathogens, but little known regarding role shaping evolution pathogens. Such understanding would aid their control, the benefit public health. Our results indicate expansion agriculture influenced not only biogeography also virulence Toxoplasma gondii . By linking landscape ecology parasite virulence, framework contributes a...
Abstract Canine and feline parasitic zoonoses have not been given high priority in China, although the role of companion animals as reservoirs for zoonotic diseases has recognized worldwide. With an increasing number dogs cats under unregulated conditions canine are showing a trend towards being gradually uncontrolled. Currently, threaten human health, cause death serious China. This article comprehensively reviews current status major mainland discusses risks pose with regard to...
Ticks are blood-sucking ectoparasites of great medical and veterinary significance that can transmit bacteria, protozoa, fungi viruses, cause a variety human animal diseases worldwide.In the present study, we sequenced complete mitochondrial (mt) genome Rhipicephalus sanguineus from China (RSC) compared with R. USA (RSU).Nucleotide sequence difference in full mt was 11.23% between RSC RSU.For 13 protein-coding genes, comparison revealed divergences at both nucleotide (9.34-15.65%)and amino...
Abstract Background Analyses of mitochondrial (mt) genome sequences in recent years challenge the current working hypothesis Nematoda phylogeny proposed from morphology, ecology and nuclear small subunit rRNA gene sequences, raise need to sequence additional mt genomes for a broad range nematode lineages. Results We sequenced complete three Ascaridia species (family Ascaridiidae) that infest chickens, pigeons parrots, respectively. These have an identical arrangement genes each other but...
In recent years, surveys of Toxoplasma gondii infection in dogs have been reported worldwide, including China. However, little is known about the prevalence T. pet Northwest present study, Lanzhou, China was investigated using modified agglutination test (MAT).In this survey, antibodies to were found 28 259 (10.81%) dogs, with MAT titers 1:20 14 1:40 nine, 1:80 four, and 1:160 or higher one dog. The ranged from 6.67% 16.67% among different ages, low rates young high older dogs....
Abstract Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests. The aim this study was investigate dynamic in metabolic profile mouse sera during T. gondii infection. We carried out untargeted metabolomic analysis collected from female BALB/c mice experimentally infected Pru strain (Genotype II). Serum samples were at 7, 14 21 day post infection (DPI) control subjected liquid...
Abstract Background Toxoplasma gondii is a widely prevalent protozoan parasite that causes serious toxoplasmosis in humans and animals. The present study aimed to determine the genetic diversity of T. isolates from pigs Jiangxi, Sichuan, Guangdong Provinces Chongqing Municipality China using multilocous polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology. Methods A total 38 DNA samples were extracted hilar lymph nodes with suspected toxoplasmosis,...
Toxoplasma gondii remains a global public health problem. However, its pathophysiology is still not-completely understood particularly the impact of infection on host liver metabolism. We performed iTRAQ-based proteomic analysis to evaluate early protein responses in BALB/c mice following with T. PYS strain (genotype ToxoDB#9) infection. Our data revealed modification expression key metabolic pathways, as indicated by upregulation immune response and downregulation mitochondrial respiratory...
Toxoplasma gondii can infect a large variety of domestic and wild animals human beings, sometimes causing severe pathology. Rhoptries are involved in T. invasion host cell interaction have been implicated as important virulence factors. In this study, we constructed DNA vaccine expressing rhoptry protein 16 (ROP16) evaluated the immune responses it induced Kunming mice. The gene sequence encoding ROP16 was inserted into eukaryotic expression vector pVAX I. We immunized mice intramuscularly....
Toxoplasma gondii is an important cosmopolitan opportunistic protozoan parasite, which threatens the health of human beings and animals. Genetic characterization isolates from South America has revealed high genetic diversity. In contrast, North Europe were highly clonal, with 3 major lineages known as Types I, II, III. However, limited information on T. genotypes been reported in The People's Republic China. Here we conducted a survey to determine diversity this parasite wild birds total,...
MicroRNAs (miRNAs) are key regulators of gene expression at the post-transcription level. The present study specifically explored and compared miRNA profiles F. gigantica hepatica using an integrated sequencing bioinformatics platform quantitative real-time PCR. Nineteen 16 candidates were identified from hepatica, respectively. two parasites shared 11 miRNAs, with 8 also showing similarity to miRNAs Schistosoma japonicum. Another as gigantica-specific 5 hepatica-specific, most which novel....
Giardia duodenalis is a zoonotic parasite that causes gastrointestinal diseases in both humans and animals. To evaluate the prevalence genetic diversity of G. black goats, we collected 539 fecal samples from nine districts Fujian Province, China. The presence was confirmed through nested PCR targeting SSU rRNA gene, genotyping performed at beta-giardin, glutamate dehydrogenase, triosephosphate isomerase loci. Among samples, 115 tested positive, yielding an overall infection rate 21.34%....
Complete mitochondrial (mt) genomes and the gene rearrangements are increasingly used as molecular markers for investigating phylogenetic relationships. Contributing to complete mt of Gastropoda, especially Pulmonata, we determined genome freshwater snail Galba pervia, which is an important intermediate host Fasciola spp. in China. The G. pervia 13,768 bp length. Its circular, consists 37 genes, including 13 genes proteins, 2 rRNA, 22 tRNA. order showed novel arrangement (tRNA-His, tRNA-Gly...
Abstract Background Toxoplasma gondii is an intracellular protozoan parasite infecting almost all warm-blooded animals, including birds, with a worldwide distribution. Surveys of T. infection in wild birds have been reported extensively the world, but little known peafowls worldwide. This study was performed to determine seroprevalence Yunnan Province, southwestern China. Methods Sera from 277 peafowls, 272 blue ( Pavo cristatus ) and 5 green muticus originated two geographic areas Province...